Evidence map›Paper›PMID 27464893›Full record

ArticleMagnetic resonance in medicine2017

Preconditioned total field inversion (TFI) method for quantitative susceptibility mapping.

Zhe Liu, Youngwook Kee, Dong Zhou, Yi Wang, Pascal Spincemaille

Abstract read
In one paragraph

Article in Magnetic resonance in medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed
13.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 124 citations in OpenAlex.

  1. Article
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  5. ArXiv · 2025
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  9. Sensitivity assessment of QSM+qBOLD (or QQ) in detecting elevated oxygen extraction fraction (OEF) in physiological change.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2025
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  15. QSM Throughout the Body.Journal of magnetic resonance imaging : JMRI · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Zhe LiuDepartment of Biomedical Engineering, Cornell University, Ithaca, New York, USA.
Youngwook KeeDepartment of Radiology, Weill Cornell Medical College, New York, New York, USA.
Dong ZhouDepartment of Radiology, Weill Cornell Medical College, New York, New York, USA.
Yi WangDepartment of Biomedical Engineering, Cornell University, Ithaca, New York, USA.
Pascal SpincemailleDepartment of Radiology, Weill Cornell Medical College, New York, New York, USA.
Cornell University · US

Funding

Quantitative Mapping of Substantia Nigra Iron in Parkinson's DiseaseR01NS095562 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI SHTILBANS, ALEXANDER, WANG, YI · 2016 to 2022
$3.1M
Multiple Sclerosis Lesion Magnetic Susceptibility ActivityR01NS090464 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI WANG, YI · 2015 to 2020
$2.3M
3.0T Magnetic Resonance Imaging System for Preclinical, Translational and Clinical ResearchS10OD021782 · OD · WEILL MEDICAL COLL OF CORNELL UNIV · PI WANG, YI · 2016 to 2016
$2.0M
Compact Representations of Dynamic Liver MRIR01CA181566 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI SPINCEMAILLE, PASCAL · 2015 to 2019
$1.9M
MRI method for quantitatively mapping cerebral microbleedsR01NS072370 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI WANG, YI · 2011 to 2015
$1.8M
Analyses of gradient echo MRI dataR01EB013443 · NIBIB · WEILL MEDICAL COLL OF CORNELL UNIV · PI WANG, YI · 2011 to 2014
$1.5M
NCI NIH HHS R01 CA181566NIBIB NIH HHS R01 EB013443NIH HHS S10 OD021782NINDS NIH HHS R01 NS072370NINDS NIH HHS R01 NS090464NINDS NIH HHS R01 NS095562
6 · The paper itself

Abstract

purposeTo investigate systematic errors in traditional quantitative susceptibility mapping (QSM) where background field removal and local field inversion (LFI) are performed sequentially, to develop a total field inversion (TFI) QSM method to reduce these errors, and to improve QSM quality in the presence of large susceptibility differences. THEORY AND

methodsThe proposed TFI is a single optimization problem which simultaneously estimates the background and local fields, preventing error propagation from background field removal to QSM. To increase the computational speed, a new preconditioner is introduced and analyzed. TFI is compared with the traditional combination of background field removal and LFI in a numerical simulation and in phantom, 5 healthy subjects, and 18 patients with intracerebral hemorrhage.

resultsCompared with the traditional method projection onto dipole fields+LFI, preconditioned TFI substantially reduced error in QSM along the air-tissue boundaries in simulation, generated high-quality in vivo QSM within similar processing time, and suppressed streaking artifacts in intracerebral hemorrhage QSM. Moreover, preconditioned TFI was capable of generating QSM for the entire head including the brain, air-filled sinus, skull, and fat.

conclusionPreconditioned total field inversion improves the accuracy of QSM over the traditional method where background and local fields are separately estimated. Magn Reson Med 78:303-315, 2017. © 2016 International Society for Magnetic Resonance in Medicine.

Indexed as

AlgorithmsBrainCerebral HemorrhageHumansImage EnhancementImage Interpretation, Computer-AssistedMagnetic Resonance ImagingPhantoms, ImagingReproducibility of ResultsSensitivity and Specificitybackground field removalpreconditioningQSMtotal field inversion

Identifiers

PMID27464893
PMCPMC5274595
OpenAlexW2500241102

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.