Evidence map›Paper›PMID 27464788›Full record

ArticleJournal of the American Heart Association2016

One Minute of Marijuana Secondhand Smoke Exposure Substantially Impairs Vascular Endothelial Function.

Xiaoyin Wang, Ronak Derakhshandeh, Jiangtao Liu, Shilpa Narayan, Pooneh Nabavizadeh, Stephenie Le, Olivia M Danforth, Kranthi Pinnamaneni, Hilda J Rodriguez, Emmy Luu and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Heart Association, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed, 1 pooled it
11.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

72 citing papers in PubMed, 1 synthesis or guideline pooled it, 139 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Cannabis Use Among Older Adults.JAMA network open · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Association of Cannabis Use With Cardiovascular Outcomes Among US Adults.Journal of the American Heart Association · 2024
    Article
  16. Review
  17. Article
  18. Article
  19. Role of Cannabinoid Signaling in Cardiovascular Function and Ischemic Injury.The Journal of pharmacology and experimental therapeutics · 2023
    Review
  20. Article

12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 2 countries.

Xiaoyin WangCardiovascular Research Institute, University of California, San Francisco.
Ronak DerakhshandehCardiovascular Research Institute, University of California, San Francisco.
Jiangtao LiuDivision of Cardiology, University of California, San Francisco Department of Cardiovascular Surgery & Electro-chemotherapy, China-Japan Friendship Hospital, Beijing, People's Republic of China.
Shilpa NarayanCardiovascular Research Institute, University of California, San Francisco Division of Cardiology, University of California, San Francisco.
Pooneh NabavizadehDivision of Cardiology, University of California, San Francisco.
Stephenie LeDivision of Cardiology, University of California, San Francisco.
Olivia M DanforthCardiovascular Research Institute, University of California, San Francisco.
Kranthi PinnamaneniCardiovascular Research Institute, University of California, San Francisco.
Hilda J RodriguezDivision of Cardiology, University of California, San Francisco Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco.
Emmy LuuDivision of Cardiology, University of California, San Francisco.
Richard E SieversDivision of Cardiology, University of California, San Francisco.
Suzaynn F SchickDivision of Occupational and Environmental Medicine, University of California, San Francisco.
Stanton A GlantzCardiovascular Research Institute, University of California, San Francisco Division of Cardiology, University of California, San Francisco.
Matthew L SpringerCardiovascular Research Institute, University of California, San Francisco Division of Cardiology, University of California, San Francisco Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco matt.springer@ucsf.edu.
University of California, San Francisco · USBroad Center · US

Funding

Evaluation of harmful effects of cannabis smoke on vascular endothelial functionR21DA031966 · NIDA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SPRINGER, MATTHEW LAWRENCE · 2011 to 2012
$425k
NIDA NIH HHS R21 DA031966
6 · The paper itself

Abstract

backgroundDespite public awareness that tobacco secondhand smoke (SHS) is harmful, many people still assume that marijuana SHS is benign. Debates about whether smoke-free laws should include marijuana are becoming increasingly widespread as marijuana is legalized and the cannabis industry grows. Lack of evidence for marijuana SHS causing acute cardiovascular harm is frequently mistaken for evidence that it is harmless, despite chemical and physical similarity between marijuana and tobacco smoke. We investigated whether brief exposure to marijuana SHS causes acute vascular endothelial dysfunction. METHODS AND

resultsWe measured endothelial function as femoral artery flow-mediated dilation (FMD) in rats before and after exposure to marijuana SHS at levels similar to real-world tobacco SHS conditions. One minute of exposure to marijuana SHS impaired FMD to a comparable extent as impairment from equal concentrations of tobacco SHS, but recovery was considerably slower for marijuana. Exposure to marijuana SHS directly caused cannabinoid-independent vasodilation that subsided within 25 minutes, whereas FMD remained impaired for at least 90 minutes. Impairment occurred even when marijuana lacked cannabinoids and rolling paper was omitted. Endothelium-independent vasodilation by nitroglycerin administration was not impaired. FMD was not impaired by exposure to chamber air.

conclusionsOne minute of exposure to marijuana SHS substantially impairs endothelial function in rats for at least 90 minutes, considerably longer than comparable impairment by tobacco SHS. Impairment of FMD does not require cannabinoids, nicotine, or rolling paper smoke. Our findings in rats suggest that SHS can exert similar adverse cardiovascular effects regardless of whether it is from tobacco or marijuana.

Indexed as

Air PollutionAnimalsCoronary CirculationEndothelium, VascularFemaleMarijuana SmokingNitric OxideNitroglycerinPeripheral Vascular DiseasesRats, Sprague-DawleySmokeTime FactorsVasodilationVasodilator AgentsNitric OxideNitroglycerinSmokeVasodilator Agentsarterycannabisendotheliumflow‐mediated dilationmarijuananitric oxide synthasesecondhand smokesmokingvasodilation

Identifiers

PMID27464788
PMCPMC5015303
OpenAlexW2502101185

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.