ArticleScience translational medicine2016
Maternal HIV infection influences the microbiome of HIV-uninfected infants.
Article in Science translational medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 81 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
81 citing papers in PubMed, 4 syntheses or guidelines pooled it, 119 citations in OpenAlex.
- Breastfeeding Affects Concentration of Faecal Short Chain Fatty Acids During the First Year of Life: Results of the Systematic Review and Meta-Analysis.Frontiers in nutrition · 2022Pooled it
- Investigating the infant gut microbiota in developing countries: worldwide metagenomic meta-analysis involving infants living in sub-urban areas of Côte d'Ivoire.Environmental microbiology reports · 2021Pooled it
- Meta-analysis of effects of exclusive breastfeeding on infant gut microbiota across populations.Nature communications · 2018Pooled it
- Maternal exposures and the infant gut microbiome: a systematic review with meta-analysis.Gut microbesPooled it
- The effects of revised peer-counselor support on the PMTCT cascade of care: results from a cluster-randomized trial in Kenya (the EMMA study).BMC infectious diseases · 2023Trial
- Dynamic Changes in Breast Milk Microbiome in the Early Postpartum Period of Kenyan Women Living with HIV Are Influenced by Antibiotics but Not Antiretrovirals.Microbiology spectrum · 2022Trial
- Metagenomic analysis of the gut microbiome composition associated with vitamin D supplementation in Taiwanese infants.Scientific reports · 2021Trial
- Mother-to-offspring microbial vertical transmission: timing, determinants, and impact on offspring susceptibility to gastrointestinal diseases.Medical review (2021) · 2026Review
- Impact of maternal HIV infection on the gut microbiome and metabolome of mothers and infants: the PRACHITi cohort in Pune, India.Nature communications · 2026Article
- Mechanistic insights into the impact of prenatal viral infections on maternal and offspring immunity.Npj viruses · 2026Review
- The influence of breast milk microbiota from HIV-infected women on infant gut microbiota colonization within the first two weeks of life.Frontiers in microbiomes · 2026Article
- Altered milk tryptophan and tryptophan metabolites in women living with HIV.Nature communications · 2025Article
- Longitudinal Analysis of Nasopharyngeal Microbial Risk Markers for Fatal Acute Febrile Illness in a Zambian Birth Cohort.The Journal of infectious diseases · 2025Article
- Gut microbiome associations with poliovirus vaccine seroconversion in children in the Democratic Republic of the Congo.bioRxiv : the preprint server for biology · 2025Article
- Effect of maternal HIV status on the early neonatal microbiome.Journal of the Pediatric Infectious Diseases Society · 2025Article
- Gut microbiota of sub-Saharan Africa infants exposed to antiretroviral therapy: Scoping review.African journal of primary health care & family medicine · 2025Article
- Associations between perinatal HIV-related risk factors and select serum PUFA levels among Ugandan children and adolescents.Public health nutrition · 2025Article
- Gut microbiota and other factors associated with increased T cell regulation in HIV-exposed uninfected infants.Frontiers in immunology · 2025Article
- Effect of in utero and lactational exposure to antiretroviral therapy on the gut microbial composition and metabolic function in aged rat offspring.Experimental biology and medicine (Maywood, N.J.) · 2025Article
- Intestinal dysbiosis during pregnancy and microbiota-associated impairments in offspring.Frontiers in microbiomes · 2025Review
21 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
17 authors at 2 institutions in 1 country.
Funding
Abstract
More than 1 million HIV-exposed, uninfected infants are born annually to HIV-positive mothers worldwide. This growing population of infants experiences twice the mortality of HIV-unexposed infants. We found that although there were very few differences seen in the microbiomes of mothers with and without HIV infection, maternal HIV infection was associated with changes in the microbiome of HIV-exposed, uninfected infants. Furthermore, we observed that human breast milk oligosaccharides were associated with bacterial species in the infant microbiome. The disruption of the infant's microbiome associated with maternal HIV infection may contribute to the increased morbidity and mortality of HIV-exposed, uninfected infants.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.