ArticleScience (New York, N.Y.)2016
Competition between engrams influences fear memory formation and recall.
Article in Science (New York, N.Y.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 206 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
206 citing papers in PubMed.
- Reduced dorsal CA1 activity limits retention of the temporal component of declarative memory in theeLife · 2026Article
- Multiple-context extinction strengthens fear suppression through hippocampal dopamine D2R-dependent memory updating.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Motor priming is associated with widespread recruitment into neural ensembles and more rapid ensemble transitions.iScience · 2026Article
- Slow Oscillation-Sleep Spindle Coupling Is Associated With Expectancy Measures of Fear Extinction Retention in Trauma-Exposed Individuals.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Generalization of negative memories drives the development of psychological distress-related behaviors.Innovation (Cambridge (Mass.)) · 2026Article
- The intrinsic excitability of and autophagy protein expression levels in dentate gyrus ensembles regulate fear generalization.Neural regeneration research · 2026Article
- Old mice fail to integrate a memory update into an existing hippocampal engram.bioRxiv : the preprint server for biology · 2026Article
- A computational framework for epigenetic plasticity in memory.Brain : a journal of neurology · 2026Review
- Primary cilia and neural computation.Journal of biomedical science · 2026Review
- CA1 Engram Cell Dynamics Before and After Learning.bioRxiv : the preprint server for biology · 2026Article
- State-dependent geometric transformations in the mouse hippocampus support fear generalization without loss of discriminability.bioRxiv : the preprint server for biology · 2026Article
- Engrams and Memory: My Scientific "Eras Tour".The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Flexible Coupling of Synaptic and Intrinsic Plasticity in a Cerebellar Circuit.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Dentate Gyrus Engrams in Fear and Reward: Mechanistic Principles, Critical Gaps, and Paths to Translation.Journal of neurochemistry · 2026Review
- Robust input disentanglement through dendritic calcium-mediated action potentials.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Wakefulness regulation of memory encoding and retrieval: structure and activity.National science review · 2026Review
- Excitability-margin narrowing as a candidate gating mechanism for maladaptive circuit reactivation: a ventral CA1-centered model.Frontiers in behavioral neuroscience · 2026Article
- Cortical glutamatergic and GABAergic inputs support learning-driven hippocampal stability.Science (New York, N.Y.) · 2025Article
- Early intrinsic excitability plasticity of neocortical engram neurons defines memory formation and precision.Nature communications · 2025Article
- Writing the Engram: Epigenetic Mechanisms of Memory Allocation.Journal of neurochemistry · 2025Review
146 more citing papers are in PubMed but not listed here.
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Authors and funding
13 authors.
Funding
Abstract
Collections of cells called engrams are thought to represent memories. Although there has been progress in identifying and manipulating single engrams, little is known about how multiple engrams interact to influence memory. In lateral amygdala (LA), neurons with increased excitability during training outcompete their neighbors for allocation to an engram. We examined whether competition based on neuronal excitability also governs the interaction between engrams. Mice received two distinct fear conditioning events separated by different intervals. LA neuron excitability was optogenetically manipulated and revealed a transient competitive process that integrates memories for events occurring closely in time (coallocating overlapping populations of neurons to both engrams) and separates memories for events occurring at distal times (disallocating nonoverlapping populations to each engram).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.