ArticleThe American journal of drug and alcohol abuse2016
Salivary stress biomarkers of recent nicotine use and dependence.
Article in The American journal of drug and alcohol abuse, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 18 citations in OpenAlex.
- Determination of perceived stress, salivary cortisol and interleukin-1β levels and clinical features of chronic urticaria in patients with dermographic urticaria in comparison to patients with chronic spontaneous urticaria and healthy individuals.Frontiers in immunology · 2026Article
- Serum Levels of IL-6 and TNF-α, Salivary Morning Cortisol and Intensity of Psychological Stress in Patients with Allergic Contact Hand Dermatitis and Healthy Subjects.Life (Basel, Switzerland) · 2025Article
- A novel approach for measuring allostatic load highlights differences in stress burdens due to race, sex and smoking status.PloS one · 2025Article
- Diurnal Profiles of the Endocrine Stress Response in Internet Gaming Disorder.Psychopathology · 2025Article
- Determination of Free Solanesol Levels in Cigarette Filters by Liquid Chromatography-Mass Spectrometry.Journal of analytical toxicology · 2022Article
- Impact of tobacco and/or nicotine products on health and functioning: a scoping review and findings from the preparatory phase of the development of a new self-report measure.Harm reduction journal · 2021Article
- Altered markers of stress in depressed adolescents after acute social media use.Journal of psychiatric research · 2021Article
- The role of substance use, smoking, and inflammation in risk for suicidal behavior.Journal of affective disorders · 2019Article
- Different levels of brain-derived neurotrophic factor and cortisol in healthy heavy smokers.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2017Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundAlthough stress plays a critical role in vulnerability to nicotine use and dependence, the stress response factors that contribute to smoking behaviors remain poorly elucidated. To minimize the confounding effects of chronic nicotine use, assessing individuals with relatively short smoking histories is critical for characterizing the neurobiological substrates associated with nicotine dependence early in the course of illness.
objectivesThis pilot study examined sympathetic nervous system (alpha-amylase) and hypothalamic-pituitary-adrenal axis (cortisol, dehydroepiandrosterone) responses to the Trier Social Stress Test (TSST) in young adult smokers. Associations among objective indices of recent smoking (salivary cotinine, carbon monoxide in the breath [CO]), behavioral measures of nicotine dependence and withdrawal, and salivary biomarkers in response to the TSST were investigated.
methodsSmokers (N = 64; 28 males, 36 females) provided saliva samples at 30 min intervals for 2 h prior to the TSST and every 10 min for 1 h following the TSST.
resultsAlpha-amylase responses to the TSST were positively associated with salivary cotinine levels but negatively associated with CO levels. Individuals with a lower level of nicotine dependence had increased cortisol responses to the stressor, whereas those with a higher level of nicotine dependence did not show any cortisol changes in response to the stressor.
conclusionsThese findings indicate that different mechanisms may be involved at different levels of nicotine dependence severity. Recent nicotine use and lower dependence severity may be associated with increased activation of the stress response systems. In contrast, more severe levels of dependence may downregulate stress response systems.
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