ArticleBiophysical journal2016
Noise-Induced Increase of Sensitivity in Bacterial Chemotaxis.
Article in Biophysical journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 35 citations in OpenAlex.
- Article
- Article
- Flagellar dynamics reveal fluctuations and kinetic limit in the Escherichia coli chemotaxis network.Scientific reports · 2023Article
- The Effect of the Second Messenger c-di-GMP on Bacterial Chemotaxis in Escherichia coli.Applied and environmental microbiology · 2022Article
- A new mode of swimming in singly flagellatedProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Collective motion enhances chemotaxis in a two-dimensional bacterial swarm.Biophysical journal · 2021Article
- Swimming Escherichia coli Cells Explore the Environment by Lévy Walk.Applied and environmental microbiology · 2021Article
- Direct Mapping from Intracellular Chemotaxis Signaling to Single-Cell Swimming Behavior.Biophysical journal · 2020Article
- Bacteria push the limits of chemotactic precision to navigate dynamic chemical gradients.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Motor Adaptive Remodeling Speeds Up Bacterial Chemotactic Adaptation.Biophysical journal · 2018Article
- Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Flagellated bacteria, like Escherichia coli, can swim toward beneficial environments by modulating the rotational direction of their flagellar motors through a chemotaxis signal transduction network. The noise of this network, the random fluctuation of the intracellular concentration of the signal protein CheY-P with time, has been identified in studies of single cell behavioral variability, and found to be important in coordination of multiple motors in a bacterium and in enhancement of bacterial drift velocity in chemical gradients. Here, by comparing the behavioral difference between motors of wild-type E. coli and mutants without signal noise, we measured the magnitude of this noise in wild-type cells, and found that the noise increases the sensitivity of the bacterial chemotaxis network downstream at the level of the flagellar motor. This provided a simple mechanism for the noise-induced enhancement of chemotactic drift, which we confirmed by simulating the E. coli chemotactic motion in various spatial profiles of chemo-attractant concentration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.