ReviewOncotarget2016
Exosomes: small vesicles with big roles in hepatocellular carcinoma.
Review in Oncotarget, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 28 citations in OpenAlex.
- Extracellular Vesicles as Biomarkers in Chronic Hepatobiliary Diseases: An Overview of Their Interplay.International journal of molecular sciences · 2025Review
- miRNAs-Set of Plasmatic Extracellular Vesicles as Novel Biomarkers for Hepatocellular Carcinoma Diagnosis Across Tumor Stage and Etiologies.International journal of molecular sciences · 2025Article
- Dairy consumption and hepatocellular carcinoma risk.Annals of translational medicine · 2021Review
- Review
- [Hepatocellular carcinoma-derived exosomal miRNA expression and its clinical value].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2020Review
- The significance of exosomes in the development and treatment of hepatocellular carcinoma.Molecular cancer · 2020Review
- Exosome-mediated communication in the tumor microenvironment contributes to hepatocellular carcinoma development and progression.Journal of hematology & oncology · 2019Review
- Recent progress in the emerging role of exosome in hepatocellular carcinoma.Cell proliferation · 2019Review
- Diverse perspectives to address for the future treatment of heterogeneous hepatocellular carcinoma.Heliyon · 2019Review
- Review article: systemic treatment of hepatocellular carcinoma.Alimentary pharmacology & therapeutics · 2018Review
- lncRNA-HEIH in serum and exosomes as a potential biomarker in the HCV-related hepatocellular carcinoma.Cancer biomarkers : section A of Disease markers · 2018Article
- Potential targets and clinical value of miR-490-5p in hepatocellular carcinoma: a study based on TCGA, qRT-PCR and bioinformatics analyses.International journal of clinical and experimental pathology · 2018Article
- Kaempferol induces autophagic cell death of hepatocellular carcinoma cells via activating AMPK signaling.Oncotarget · 2017Article
- RNA-seq reveals distinctive RNA profiles of small extracellular vesicles from different human liver cancer cell lines.Oncotarget · 2017Article
- Extracellular vesicles of ETV2 transfected fibroblasts stimulate endothelial cells and improve neovascularization in a murine model of hindlimb ischemia.Cytotechnology · 2017Article
- DlgR2 knockdown boosts dendritic cell activity and inhibits hepatocellular carcinoma tumorOncotarget · 2017Article
- Tumor-specific hepatic stellate cells (tHSCs) induces DIgR2 expression in dendritic cells to inhibit T cells.Oncotarget · 2017Article
- Exosomes: New players in cancer (Review).Oncology reports · 2017Review
- Quantitative proteomics reveal the anti-tumour mechanism of the carbohydrate recognition domain of Galectin-3 in Hepatocellular carcinoma.Scientific reports · 2017Article
- Cancer exosomes: wanted by many, explored by few, waiting for one.Annals of translational medicine · 2017Article
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite improvements in the diagnosis and treatment of hepatocellular carcinoma (HCC), the prognosis is still poor. Pioneering work has demonstrated a potential role for tumour cell-derived exosomes (TEXs) in HCC. TEXs can mediate immune responses, antigen presentation and intracellular communication by serving as vehicles for the transfer of proteins, viruses, lipids and RNA between cells. An improved understanding of the roles played by exosomes could lead to a powerful new strategy for preventing and treating HCC. In this review, we summarise current understanding on the topic. The literature points to two faces of TEXs in HCC: 1) They can promote invasion, metastasis, immune evasion and modulation and 2) they can act as diagnostic and prognostic biomarkers, and can be used in anti-cancer drug resistance and immunotherapy in the future.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.