Evidence map›Paper›PMID 27462930›Full record

ArticleSubstance use & misuse2016

Should the United States Government Repeal Restrictions on Buprenorphine/Naloxone Treatment?

Kenneth Blum, Mark Gold, H Westley Clark, Kristina Dushaj, Rajendra D Badgaiyan

Abstract read
In one paragraph

Article in Substance use & misuse, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Dopaminergic Homeostatic Therapy (DHTActa scientific neurology · 2025
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  6. Death by Opioids: Are there non-addictive scientific solutions?Journal of systems and integrative neuroscience · 2019
    Article
  7. Article
  8. Article
  9. Why aren't physicians prescribing more buprenorphine?Journal of substance abuse treatment · 2017
    Article
  10. Critical Analysis of White House Anti-Drug Plan.Global journal of addiction & rehabilitation medicine · 2017
    Article
  11. Article
  12. Article
  13. Hypothesizing that a Pro-Dopaminergic Regulator (KB220zClinical medical reviews and case reports · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Kenneth Bluma Department of Psychiatry & McKnight Brain Institute , University of Florida College of Medicine , Gainesville , Florida , USA.
Mark Goldd Departments of Psychiatry & Behavioral Sciences , Keck School of Medicine of USC , Los Angeles , California , USA.
H Westley Clarkh Public Health Program , Santa Clara University , Santa Clara , California , USA.
Kristina Dushajf Department of Clinical Neurology , PATH Foundation NY , New York , New York , USA.
Rajendra D Badgaiyani Department of Psychiatry and Neuroimaging , University of Minnesota , Minneapolis , Minnesota , USA.
Florida College · USKeck Hospital of USC · USSanta Clara University · USUniversity of Minnesota · US

Funding

Dopamine Neurotransmission in Tourette SyndromeR01NS073884 · NINDS · UNIVERSITY OF MINNESOTA · PI BADGAIYAN, RAJENDRA D · 2012 to 2016
$2.2M
Detection of Dopamine Release During a Cognitive TaskR21MH073624 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI BADGAIYAN, RAJENDRA D · 2005 to 2006
$368k
NIMH NIH HHS R21 MH073624NINDS NIH HHS R01 NS073884
6 · The paper itself

Abstract

Attention must be focused on needed changes to the current United States law that restricts physicians who prescribe buprenorphine for the detoxification or treatment of Opioid Use Disorder, to accepting no more than 100 patients. The current system does not provide comprehensive treatment as defined by the American Society of Addiction Medicine (ASAM) criteria. In addition, it suffers from both fragmentation and stigma and will require a significant change to comply with ASAM's call for integrated delivery of comprehensive addiction treatment. This commentary calls for the development and implementation of "best practice," by recommending caution in lifting the 100 patient limit until substantial achievement of this goal occurs. The authors call for an increase to 200 in the patient limit to be restricted to those physicians who are Board Certified in Addiction Medicine by the American Board of Addiction Medicine (ABAM) or in Addiction Psychiatry by the American Board of Psychiatry and Neurology (ABPN), or other responsible medical organizations. Any additional restriction lifting should follow a systemic evolution that rewards and documents competency. Such a system would involve the integration of treatment, treatment systems, and recovery with prescription medication. In addition, it should monitor emotional blunting, treatment progress and initiation of genetic addiction risk testing.

Indexed as

BuprenorphineBuprenorphine, Naloxone Drug CombinationGovernmentHumansNaloxoneNarcotic AntagonistsOpiate Substitution TreatmentOpioid-Related DisordersUnited StatesBuprenorphineBuprenorphine, Naloxone Drug CombinationNaloxoneNarcotic AntagonistsBuprenorphinecompetencydrug urine testinggenetic risknaloxonerestriction capUnited States law

Identifiers

PMID27462930
PMCPMC5055459
OpenAlexW2480213493

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.