Evidence map›Paper›PMID 27462910›Full record

ArticleThe Journal of organic chemistry2016

Design, Synthesis, and Biological Evaluation of Structurally Rigid Analogues of 4-(3-Hydroxyphenyl)piperidine Opioid Receptor Antagonists.

Scott P Runyon, Chad M Kormos, Moses G Gichinga, S Wayne Mascarella, Hernán A Navarro, Jeffrey R Deschamps, Gregory H Imler, F Ivy Carroll

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of organic chemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Study of Cytotoxicity of 3-Azabicyclo[3.1.0]hexanes and Cyclopropa[International journal of molecular sciences · 2025
    Article
  2. Article
  3. Article
  4. Access to 3D Alicyclic Amine-Containing Fragments through Transannular C-H Arylation.Synlett : accounts and rapid communications in synthetic organic chemistry · 2019
    Article
  5. Article
  6. Synthesis of CHFRSC advances · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Scott P RunyonResearch Triangle Institute , P.O. Box 12194, Research Triangle Park, North Carolina 27709-2194, United States.
Chad M KormosResearch Triangle Institute , P.O. Box 12194, Research Triangle Park, North Carolina 27709-2194, United States.
Moses G GichingaResearch Triangle Institute , P.O. Box 12194, Research Triangle Park, North Carolina 27709-2194, United States.
S Wayne MascarellaResearch Triangle Institute , P.O. Box 12194, Research Triangle Park, North Carolina 27709-2194, United States.
Hernán A NavarroResearch Triangle Institute , P.O. Box 12194, Research Triangle Park, North Carolina 27709-2194, United States.
Jeffrey R DeschampsNaval Research Laboratory, Code 6910, 455 Overlook Avenue, Washington, D.C. 20375, United States.
Gregory H Imler
F Ivy CarrollResearch Triangle Institute , P.O. Box 12194, Research Triangle Park, North Carolina 27709-2194, United States.

Funding

Selective Opioid Antagonists as Medications for Drug AbuseR01DA009045 · NIDA · RESEARCH TRIANGLE INSTITUTE · PI CARROLL, FRANK IVY · 1994 to 2014
$5.6M
DEVELOPMENT OF LIGANDS FOR NICOTINIC RECEPTORSR01DA012001 · NIDA · RESEARCH TRIANGLE INSTITUTE · PI CARROLL, FRANK IVY · 1999 to 2012
$4.8M
NIDA NIH HHS R01 DA009045NIDA NIH HHS R01 DA012001
6 · The paper itself

Abstract

In order to gain additional information concerning the active conformation of the N-substituted trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine (1) class of opioid receptor antagonists, procedures were developed for the synthesis of structurally rigid N-substituted-6-(3-hydroxyphenyl)3-azabicyclo[3.1.0]hexane and 3-methyl-4-(3-hydroxyphenyl)-4-azabicyclo[4.1.0]heptanes. Evaluation of the conformationally constrained series in a [

Indexed as

Bridged Bicyclo CompoundsDrug DesignMolecular StructureNarcotic AntagonistsPiperidinesProton Magnetic Resonance SpectroscopyBridged Bicyclo CompoundsNarcotic AntagonistsPiperidines

Identifiers

PMID27462910
PMCPMC5586075

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.