Evidence map›Paper›PMID 27462869›Full record

ArticleOncotarget2016

Volumetric modulated arc therapy for thoracic node metastases: a safe and effective treatment for a neglected disease.

Davide Franceschini, Fiorenza De Rose, Antonella Fogliata, Piera Navarria, Anna Maria Ascolese, Ciro Franzese, Tiziana Comito, Angelo Tozzi, Cristina Iftode, Lucia Di Brina and 4 more

Open access · diamondAbstract read
In one paragraph

Article in Oncotarget, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
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  6. Review
  7. Stereotactic radiotherapy for oligometastases in the lymph nodes.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Davide FranceschiniHumanitas Cancer Center and Research Hospital, Radiosurgery and Radiotherapy Department, 20089 Milan-Rozzano, Italy.
Fiorenza De RoseHumanitas Cancer Center and Research Hospital, Radiosurgery and Radiotherapy Department, 20089 Milan-Rozzano, Italy.
Antonella FogliataHumanitas Cancer Center and Research Hospital, Radiosurgery and Radiotherapy Department, 20089 Milan-Rozzano, Italy.
Piera NavarriaHumanitas Cancer Center and Research Hospital, Radiosurgery and Radiotherapy Department, 20089 Milan-Rozzano, Italy.
Anna Maria AscoleseHumanitas Cancer Center and Research Hospital, Radiosurgery and Radiotherapy Department, 20089 Milan-Rozzano, Italy.
Ciro FranzeseHumanitas Cancer Center and Research Hospital, Radiosurgery and Radiotherapy Department, 20089 Milan-Rozzano, Italy.
Tiziana ComitoHumanitas Cancer Center and Research Hospital, Radiosurgery and Radiotherapy Department, 20089 Milan-Rozzano, Italy.
Angelo TozziHumanitas Cancer Center and Research Hospital, Radiosurgery and Radiotherapy Department, 20089 Milan-Rozzano, Italy.
Cristina IftodeHumanitas Cancer Center and Research Hospital, Radiosurgery and Radiotherapy Department, 20089 Milan-Rozzano, Italy.
Lucia Di BrinaHumanitas Cancer Center and Research Hospital, Radiosurgery and Radiotherapy Department, 20089 Milan-Rozzano, Italy.
Giuseppe D'AgostinoHumanitas Cancer Center and Research Hospital, Radiosurgery and Radiotherapy Department, 20089 Milan-Rozzano, Italy.
Elena ClericiHumanitas Cancer Center and Research Hospital, Radiosurgery and Radiotherapy Department, 20089 Milan-Rozzano, Italy.
Luca CozziHumanitas Cancer Center and Research Hospital, Radiosurgery and Radiotherapy Department, 20089 Milan-Rozzano, Italy.
Marta ScorsettiHumanitas Cancer Center and Research Hospital, Radiosurgery and Radiotherapy Department, 20089 Milan-Rozzano, Italy.
IRCCS Humanitas Research Hospital · ITHumanitas University · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate the outcome of Stereotactic Body Radiation Therapy (SBRT) with Volumetric Modulated Arc Therapy (VMAT) for thoracic node metastases.

results18 out of 29 patients presented with isolated thoracic node metastases with no other sites of disease. Median prescribed dose was 45Gy (range 30-60Gy).Acute toxicity was recorded as G0 in 28 patients, while one patient was scored as G1. Late toxicity was G0 in 26 patients, one patient was scored G1, one as G2, and one as G4 presented acute myocardial infarction.During follow up, the best local response was complete remission in 14 patients and partial remission in 11 patients. With a median follow up of 12 months (range 2-35) 9 patients died from disease progression, 10 were still alive with distant metastases, 5 had a locally controlled disease and 5 patients were disease free.The median OS estimated was 18 months (76%, 49% at one, two years). The median PFS was 9 months (28%, 17% at one, two years). MATERIALS AND

methodsTwenty-nine patients with 32 thoracic nodes metastases were treated with SBRT in our institution. Toxicities and response were assessed. Overall Survival (OS) and Progression Free Survival (PFS) were evaluated.

conclusionsSBRT is an efficient treatment for thoracic node metastases.

Indexed as

AdultAgedAged, 80 and overFemaleHumansKaplan-Meier EstimateLymphatic MetastasisLymph NodesMaleMiddle AgedNeglected DiseasesPneumoniaRadiotherapy DosageRadiotherapy, Intensity-ModulatedRetrospective StudiesThoraxmediastinal nodesoligometastasesSBRT

Identifiers

PMID27462869
PMCPMC5288189
OpenAlexW2487041407

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.