ReviewFrontiers in neuroscience2016
From Genetics to Epigenetics: New Perspectives in Tourette Syndrome Research.
Review in Frontiers in neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Polygenic risk score-based phenome-wide association study identifies novel associations for Tourette syndrome.Translational psychiatry · 2023Pooled it
- Tic disorders and allergic diseases: mechanistic links and the impact of allergy management - a narrative review.Frontiers in allergy · 2026Review
- Oligogenic risk score for Gilles de la Tourette syndrome reveals a genetic continuum of tic disorders.Journal of applied genetics · 2025Article
- Environmental moderators of tic severity and quality of life in children with tic disorders.European journal of pediatrics · 2025Article
- Epigenetic modifications in developmental coordination disorder: association between DNA methylation and motor performance.Frontiers in cell and developmental biology · 2025Article
- Structural Variants and Implicated Processes Associated with Familial Tourette Syndrome.International journal of molecular sciences · 2024Article
- Improve-RRBS: a novel tool to correct the 3' trimming of reduced representation sequencing reads.Bioinformatics advances · 2024Article
- A review of common influencing factors and possible mechanisms associated with allergic diseases complicating tic disorders in children.Frontiers in pediatrics · 2024Review
- Copy Number Variations in Children with Tourette Syndrome: Systematic Investigation in a Clinical Setting.Genes · 2023Article
- Association of Pre- and Perinatal Risk Factors With Tourette Syndrome or Chronic Tic Disorders in a Korean School-Age Population.Journal of the Korean Academy of Child and Adolescent Psychiatry · 2023Article
- Set2 family regulates mycotoxin metabolism and virulence via H3K36 methylation in pathogenic fungusVirulence · 2022Article
- X-linked myotubular myopathy is associated with epigenetic alterations and is ameliorated by HDAC inhibition.Acta neuropathologica · 2022Article
- Hair cortisol-a stress marker in children and adolescents with chronic tic disorders? A large European cross-sectional study.European child & adolescent psychiatry · 2022Article
- Tourette syndrome or PANDAS-a case report.Wiener medizinische Wochenschrift (1946) · 2021Article
- Article
- Association of Genetic Variation in the 3'UTR of LHX6, IMMP2L, and AADAC With Tourette Syndrome.Frontiers in neurology · 2020Article
- Cytosine Methylation Studies in Patients with Diabetic Kidney Disease.Current diabetes reports · 2019Review
- Perinatal risk factors in Tourette's and chronic tic disorders: a total population sibling comparison study.Molecular psychiatry · 2018Article
- Inhibition of DNA methyltransferase leads to increased genomic 5-hydroxymethylcytosine levels in hematopoietic cells.FEBS open bio · 2018Article
- Progress in Genetic Studies of Tourette's Syndrome.Brain sciences · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gilles de la Tourette Syndrome (TS) is a neurodevelopmental disorder marked by the appearance of multiple involuntary motor and vocal tics. TS presents high comorbidity rates with other disorders such as attention deficit hyperactivity disorder (ADHD) and obsessive compulsive disorder (OCD). TS is highly heritable and has a complex polygenic background. However, environmental factors also play a role in the manifestation of symptoms. Different epigenetic mechanisms may represent the link between these two causalities. Epigenetic regulation has been shown to have an impact in the development of many neuropsychiatric disorders, however very little is known about its effects on Tourette Syndrome. This review provides a summary of the recent findings in genetic background of TS, followed by an overview on different epigenetic mechanisms, such as DNA methylation, histone modifications, and non-coding RNAs in the regulation of gene expression. Epigenetic studies in other neurological and psychiatric disorders are discussed along with the TS-related epigenetic findings available in the literature to date. Moreover, we are proposing that some general epigenetic mechanisms seen in other neuropsychiatric disorders may also play a role in the pathogenesis of TS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.