Evidence map›Paper›PMID 27462092›Full record

ArticleThe Journal of infectious diseases2016

Relationship Between HIV Coinfection, Interleukin 10 Production, and Mycobacterium tuberculosis in Human Lymph Node Granulomas.

Collin R Diedrich, Jennifer O'Hern, Maximiliano G Gutierrez, Nafiesa Allie, Patricia Papier, Graeme Meintjes, Anna K Coussens, Helen Wainwright, Robert J Wilkinson

Open access · hybridAbstract read
In one paragraph

Article in The Journal of infectious diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 37 citations in OpenAlex.

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  15. Article
  16. Pathogenesis of Human Immunodeficiency Virus-Journal of clinical medicine · 2020
    Review
  17. A Role of Intracellular Toll-Like Receptors (3, 7, and 9) in Response toInternational journal of molecular sciences · 2020
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Collin R DiedrichClinical Infectious Diseases Research Initiative, Institute of Infectious Disease and Molecular Medicine.
Jennifer O'HernClinical Infectious Diseases Research Initiative, Institute of Infectious Disease and Molecular Medicine.
Maximiliano G GutierrezFrancis Crick Institute Mill Hill Laboratory.
Nafiesa AllieDivision of Anatomical Pathology.
Patricia PapierDivision of Anatomical Pathology.
Graeme MeintjesClinical Infectious Diseases Research Initiative, Institute of Infectious Disease and Molecular Medicine.
Anna K CoussensClinical Infectious Diseases Research Initiative, Institute of Infectious Disease and Molecular Medicine.
Helen WainwrightDivision of Anatomical Pathology.
Robert J WilkinsonClinical Infectious Diseases Research Initiative, Institute of Infectious Disease and Molecular Medicine.
The Francis Crick Institute · GBUniversity of Cape Town · ZA

Funding

Wellcome Trust 084323Wellcome Trust 104803
6 · The paper itself

Abstract

backgroundHuman immunodeficiency virus type 1 (HIV)-infected persons are more susceptible to tuberculosis than HIV-uninfected persons. Low peripheral CD4

methodsWe examined 71 excised cervical lymph nodes (LNs) from persons with HIV and M. tuberculosis coinfection, those with HIV monoinfection, and those with M. tuberculosis monoinfection with a spectrum of peripheral CD4

resultsHIV increased M. tuberculosis numbers and reduced CD4

conclusionsPeripheral CD4

Indexed as

AdultAgedCD4 Lymphocyte CountCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCoinfectionFemaleGranulomaHIV-1HIV InfectionsHumansInterferon-gammaInterleukin-10Lymph NodesMaleMiddle AgedIL10 protein, humanInterferon-gammaInterleukin-10antiretroviral therapycoinfectiongranulomahistologyHIVIL-10lymph nodemycobacteriumtuberculosis

Identifiers

PMID27462092
PMCPMC5079364
OpenAlexW2495662204

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.