SynthesisCanadian journal of psychiatry. Revue canadienne de psychiatrie2017
Meta-analysis of the Interval between the Onset and Management of Bipolar Disorder.
Synthesis in Canadian journal of psychiatry. Revue canadienne de psychiatrie, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
80 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Early interventions in mental health services: a rapid review of systematic review.Frontiers in public health · 2026Pooled it
- Neurophysiological profiles of patients with bipolar disorders as probed with transcranial magnetic stimulation: A systematic review.Neuropsychopharmacology reports · 2024Pooled it
- A qualitative study exploring youth's experiences of hospital- and integrated community-based mental health services: the YouthCan IMPACT initiative.BMC psychiatry · 2025Trial
- Psychometric Properties of the Turkish Version of the Rapid Mood Screener for Bipolar Disorder (RMS-T): A Validity and Reliability Study.Bipolar disorders · 2026Article
- Improving diagnosis and support for people with bipolar in primary care.The British journal of general practice : the journal of the Royal College of General Practitioners · 2026Article
- Observational
- Brainwide Structural Markers of Familial and Clinical Risk for Bipolar Disorder in Youth.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Dissociative Bipolar At-Risk Phenotype: Traumatic Burden and Subthreshold Affective Psychopathology in a Help-Seeking Youth Sample.Brain sciences · 2026Article
- Voice-based machine learning for rapid screening of bipolar disorder and major depressive disorder in children and adolescents: a robust and low-complexity diagnostic model.BMC psychiatry · 2026Article
- Lurasidone-Associated Urinary Retention in a Patient With Bipolar Affective Disorder: A Case Report.Case reports in psychiatry · 2026Article
- Neural correlates of cognitive improvement over time in patients newly diagnosed with bipolar disorder.Neuroscience applied · 2026Article
- Advancing the prediction of factors associated with bipolar disorder risk: utilizing early recognition tools and polygenic risk scores.International journal of bipolar disorders · 2025Article
- Article
- Addressing the unmet needs of bipolar disorder in Australia and beyond.The Australian and New Zealand journal of psychiatry · 2025Article
- Prediction of early-onset bipolar using electronic health records.Journal of child psychology and psychiatry, and allied disciplines · 2025Article
- Longitudinal stability of mood-related resting-state networks in youth with symptomatic bipolar-I/II disorder.Translational psychiatry · 2025Article
- Common and disease-specific patterns of functional connectivity and topology alterations across unipolar and bipolar disorder during depressive episodes: a transdiagnostic study.Translational psychiatry · 2025Article
- Alternations of Plasma Fatty Acids in Patients With Bipolar Depression Under Acute Treatment of rTMS Combined With Quetiapine and Mood Stabilizer.Brain and behavior · 2025Article
- Person-level contributions of bipolar polygenic risk score to the prediction of new-onset bipolar disorder in at-risk offspring.Journal of affective disorders · 2025Article
- Predicting Conversion From Unipolar Depression to Bipolar Disorder and Schizophrenia: A 10-Year Retrospective Cohort Study on 12,182 Inpatients.Depression and anxiety · 2025Article
20 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the length of the interval between the onset and the initial management of bipolar disorder (BD).
methodWe conducted a meta-analysis using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Systematic searches located studies reporting estimates of the age of onset (AOO) and indicators of the age at initial management of BD. We calculated a pooled estimate of the interval between AOO and age at management. Factors influencing between-study heterogeneity were investigated using sensitivity analyses, meta-regression, and multiple meta-regression.
resultsTwenty-seven studies, reporting 51 samples and a total of 9415 patients, met the inclusion criteria. The pooled estimate for the interval between the onset of BD and its management was 5.8 years (standardized difference, .53; 95% confidence interval, .45 to .62). There was very high between-sample heterogeneity ( I
conclusionsThere is currently little consistency in the way researchers report the AOO and initial management of BD. However, the large interval between onset and management of BD presents an opportunity for earlier intervention.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.