ArticleCirculation research2016
Acute Catecholamine Exposure Causes Reversible Myocyte Injury Without Cardiac Regeneration.
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Article in Circulation research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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55citing papers in PubMed
9.4field-weighted citation impact, top 2% of its field
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Who cites it
55 citing papers in PubMed, 96 citations in OpenAlex.
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Authors and funding
22 authors at 4 institutions in 1 country.
Markus WallnerFrom the Cardiovascular Research Center (M.W., J.M.D., S.M., C.D.T., G.B., P.G., D.M.T., H.K., T.E.S., S.C.H., M.A.V., T.S., E.A.F., R.M.B., T.W., S.R.H.), Department of Clinical Sciences (D.Y.), and Department of Anatomy and Cell Biology (M.F.B.), Lewis Katz School of Medicine, Temple University, Philadelphia, PA; Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, OH (D.V., R.J.V., J.D.M.); Department of Pediatrics, Drexel University College of Medicine, Philadelphia, PA (A.T.); Howard Hughes Medical Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH (J.D.M.); and Department of Internal Medicine, University of California San Diego Medical Center, San Diego, CA (J.M.D.).
Jason M DuranFrom the Cardiovascular Research Center (M.W., J.M.D., S.M., C.D.T., G.B., P.G., D.M.T., H.K., T.E.S., S.C.H., M.A.V., T.S., E.A.F., R.M.B., T.W., S.R.H.), Department of Clinical Sciences (D.Y.), and Department of Anatomy and Cell Biology (M.F.B.), Lewis Katz School of Medicine, Temple University, Philadelphia, PA; Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, OH (D.V., R.J.V., J.D.M.); Department of Pediatrics, Drexel University College of Medicine, Philadelphia, PA (A.T.); Howard Hughes Medical Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH (J.D.M.); and Department of Internal Medicine, University of California San Diego Medical Center, San Diego, CA (J.M.D.).
Sadia MohsinFrom the Cardiovascular Research Center (M.W., J.M.D., S.M., C.D.T., G.B., P.G., D.M.T., H.K., T.E.S., S.C.H., M.A.V., T.S., E.A.F., R.M.B., T.W., S.R.H.), Department of Clinical Sciences (D.Y.), and Department of Anatomy and Cell Biology (M.F.B.), Lewis Katz School of Medicine, Temple University, Philadelphia, PA; Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, OH (D.V., R.J.V., J.D.M.); Department of Pediatrics, Drexel University College of Medicine, Philadelphia, PA (A.T.); Howard Hughes Medical Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH (J.D.M.); and Department of Internal Medicine, University of California San Diego Medical Center, San Diego, CA (J.M.D.).
Constantine D TroupesFrom the Cardiovascular Research Center (M.W., J.M.D., S.M., C.D.T., G.B., P.G., D.M.T., H.K., T.E.S., S.C.H., M.A.V., T.S., E.A.F., R.M.B., T.W., S.R.H.), Department of Clinical Sciences (D.Y.), and Department of Anatomy and Cell Biology (M.F.B.), Lewis Katz School of Medicine, Temple University, Philadelphia, PA; Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, OH (D.V., R.J.V., J.D.M.); Department of Pediatrics, Drexel University College of Medicine, Philadelphia, PA (A.T.); Howard Hughes Medical Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH (J.D.M.); and Department of Internal Medicine, University of California San Diego Medical Center, San Diego, CA (J.M.D.).
Davy VanhoutteFrom the Cardiovascular Research Center (M.W., J.M.D., S.M., C.D.T., G.B., P.G., D.M.T., H.K., T.E.S., S.C.H., M.A.V., T.S., E.A.F., R.M.B., T.W., S.R.H.), Department of Clinical Sciences (D.Y.), and Department of Anatomy and Cell Biology (M.F.B.), Lewis Katz School of Medicine, Temple University, Philadelphia, PA; Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, OH (D.V., R.J.V., J.D.M.); Department of Pediatrics, Drexel University College of Medicine, Philadelphia, PA (A.T.); Howard Hughes Medical Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH (J.D.M.); and Department of Internal Medicine, University of California San Diego Medical Center, San Diego, CA (J.M.D.).
Giulia BorghettiFrom the Cardiovascular Research Center (M.W., J.M.D., S.M., C.D.T., G.B., P.G., D.M.T., H.K., T.E.S., S.C.H., M.A.V., T.S., E.A.F., R.M.B., T.W., S.R.H.), Department of Clinical Sciences (D.Y.), and Department of Anatomy and Cell Biology (M.F.B.), Lewis Katz School of Medicine, Temple University, Philadelphia, PA; Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, OH (D.V., R.J.V., J.D.M.); Department of Pediatrics, Drexel University College of Medicine, Philadelphia, PA (A.T.); Howard Hughes Medical Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH (J.D.M.); and Department of Internal Medicine, University of California San Diego Medical Center, San Diego, CA (J.M.D.).
Ronald J VagnozziFrom the Cardiovascular Research Center (M.W., J.M.D., S.M., C.D.T., G.B., P.G., D.M.T., H.K., T.E.S., S.C.H., M.A.V., T.S., E.A.F., R.M.B., T.W., S.R.H.), Department of Clinical Sciences (D.Y.), and Department of Anatomy and Cell Biology (M.F.B.), Lewis Katz School of Medicine, Temple University, Philadelphia, PA; Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, OH (D.V., R.J.V., J.D.M.); Department of Pediatrics, Drexel University College of Medicine, Philadelphia, PA (A.T.); Howard Hughes Medical Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH (J.D.M.); and Department of Internal Medicine, University of California San Diego Medical Center, San Diego, CA (J.M.D.).
Polina GrossFrom the Cardiovascular Research Center (M.W., J.M.D., S.M., C.D.T., G.B., P.G., D.M.T., H.K., T.E.S., S.C.H., M.A.V., T.S., E.A.F., R.M.B., T.W., S.R.H.), Department of Clinical Sciences (D.Y.), and Department of Anatomy and Cell Biology (M.F.B.), Lewis Katz School of Medicine, Temple University, Philadelphia, PA; Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, OH (D.V., R.J.V., J.D.M.); Department of Pediatrics, Drexel University College of Medicine, Philadelphia, PA (A.T.); Howard Hughes Medical Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH (J.D.M.); and Department of Internal Medicine, University of California San Diego Medical Center, San Diego, CA (J.M.D.).
Daohai YuFrom the Cardiovascular Research Center (M.W., J.M.D., S.M., C.D.T., G.B., P.G., D.M.T., H.K., T.E.S., S.C.H., M.A.V., T.S., E.A.F., R.M.B., T.W., S.R.H.), Department of Clinical Sciences (D.Y.), and Department of Anatomy and Cell Biology (M.F.B.), Lewis Katz School of Medicine, Temple University, Philadelphia, PA; Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, OH (D.V., R.J.V., J.D.M.); Department of Pediatrics, Drexel University College of Medicine, Philadelphia, PA (A.T.); Howard Hughes Medical Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH (J.D.M.); and Department of Internal Medicine, University of California San Diego Medical Center, San Diego, CA (J.M.D.).
Danielle M TrappaneseFrom the Cardiovascular Research Center (M.W., J.M.D., S.M., C.D.T., G.B., P.G., D.M.T., H.K., T.E.S., S.C.H., M.A.V., T.S., E.A.F., R.M.B., T.W., S.R.H.), Department of Clinical Sciences (D.Y.), and Department of Anatomy and Cell Biology (M.F.B.), Lewis Katz School of Medicine, Temple University, Philadelphia, PA; Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, OH (D.V., R.J.V., J.D.M.); Department of Pediatrics, Drexel University College of Medicine, Philadelphia, PA (A.T.); Howard Hughes Medical Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH (J.D.M.); and Department of Internal Medicine, University of California San Diego Medical Center, San Diego, CA (J.M.D.).
Hajime KuboFrom the Cardiovascular Research Center (M.W., J.M.D., S.M., C.D.T., G.B., P.G., D.M.T., H.K., T.E.S., S.C.H., M.A.V., T.S., E.A.F., R.M.B., T.W., S.R.H.), Department of Clinical Sciences (D.Y.), and Department of Anatomy and Cell Biology (M.F.B.), Lewis Katz School of Medicine, Temple University, Philadelphia, PA; Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, OH (D.V., R.J.V., J.D.M.); Department of Pediatrics, Drexel University College of Medicine, Philadelphia, PA (A.T.); Howard Hughes Medical Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH (J.D.M.); and Department of Internal Medicine, University of California San Diego Medical Center, San Diego, CA (J.M.D.).
Amir ToibFrom the Cardiovascular Research Center (M.W., J.M.D., S.M., C.D.T., G.B., P.G., D.M.T., H.K., T.E.S., S.C.H., M.A.V., T.S., E.A.F., R.M.B., T.W., S.R.H.), Department of Clinical Sciences (D.Y.), and Department of Anatomy and Cell Biology (M.F.B.), Lewis Katz School of Medicine, Temple University, Philadelphia, PA; Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, OH (D.V., R.J.V., J.D.M.); Department of Pediatrics, Drexel University College of Medicine, Philadelphia, PA (A.T.); Howard Hughes Medical Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH (J.D.M.); and Department of Internal Medicine, University of California San Diego Medical Center, San Diego, CA (J.M.D.).
Thomas E SharpFrom the Cardiovascular Research Center (M.W., J.M.D., S.M., C.D.T., G.B., P.G., D.M.T., H.K., T.E.S., S.C.H., M.A.V., T.S., E.A.F., R.M.B., T.W., S.R.H.), Department of Clinical Sciences (D.Y.), and Department of Anatomy and Cell Biology (M.F.B.), Lewis Katz School of Medicine, Temple University, Philadelphia, PA; Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, OH (D.V., R.J.V., J.D.M.); Department of Pediatrics, Drexel University College of Medicine, Philadelphia, PA (A.T.); Howard Hughes Medical Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH (J.D.M.); and Department of Internal Medicine, University of California San Diego Medical Center, San Diego, CA (J.M.D.).
Shavonn C HarperFrom the Cardiovascular Research Center (M.W., J.M.D., S.M., C.D.T., G.B., P.G., D.M.T., H.K., T.E.S., S.C.H., M.A.V., T.S., E.A.F., R.M.B., T.W., S.R.H.), Department of Clinical Sciences (D.Y.), and Department of Anatomy and Cell Biology (M.F.B.), Lewis Katz School of Medicine, Temple University, Philadelphia, PA; Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, OH (D.V., R.J.V., J.D.M.); Department of Pediatrics, Drexel University College of Medicine, Philadelphia, PA (A.T.); Howard Hughes Medical Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH (J.D.M.); and Department of Internal Medicine, University of California San Diego Medical Center, San Diego, CA (J.M.D.).
Michael A VolkertFrom the Cardiovascular Research Center (M.W., J.M.D., S.M., C.D.T., G.B., P.G., D.M.T., H.K., T.E.S., S.C.H., M.A.V., T.S., E.A.F., R.M.B., T.W., S.R.H.), Department of Clinical Sciences (D.Y.), and Department of Anatomy and Cell Biology (M.F.B.), Lewis Katz School of Medicine, Temple University, Philadelphia, PA; Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, OH (D.V., R.J.V., J.D.M.); Department of Pediatrics, Drexel University College of Medicine, Philadelphia, PA (A.T.); Howard Hughes Medical Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH (J.D.M.); and Department of Internal Medicine, University of California San Diego Medical Center, San Diego, CA (J.M.D.).
Timothy StarostaFrom the Cardiovascular Research Center (M.W., J.M.D., S.M., C.D.T., G.B., P.G., D.M.T., H.K., T.E.S., S.C.H., M.A.V., T.S., E.A.F., R.M.B., T.W., S.R.H.), Department of Clinical Sciences (D.Y.), and Department of Anatomy and Cell Biology (M.F.B.), Lewis Katz School of Medicine, Temple University, Philadelphia, PA; Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, OH (D.V., R.J.V., J.D.M.); Department of Pediatrics, Drexel University College of Medicine, Philadelphia, PA (A.T.); Howard Hughes Medical Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH (J.D.M.); and Department of Internal Medicine, University of California San Diego Medical Center, San Diego, CA (J.M.D.).
Eric A FeldsottFrom the Cardiovascular Research Center (M.W., J.M.D., S.M., C.D.T., G.B., P.G., D.M.T., H.K., T.E.S., S.C.H., M.A.V., T.S., E.A.F., R.M.B., T.W., S.R.H.), Department of Clinical Sciences (D.Y.), and Department of Anatomy and Cell Biology (M.F.B.), Lewis Katz School of Medicine, Temple University, Philadelphia, PA; Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, OH (D.V., R.J.V., J.D.M.); Department of Pediatrics, Drexel University College of Medicine, Philadelphia, PA (A.T.); Howard Hughes Medical Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH (J.D.M.); and Department of Internal Medicine, University of California San Diego Medical Center, San Diego, CA (J.M.D.).
Remus M BerrettaFrom the Cardiovascular Research Center (M.W., J.M.D., S.M., C.D.T., G.B., P.G., D.M.T., H.K., T.E.S., S.C.H., M.A.V., T.S., E.A.F., R.M.B., T.W., S.R.H.), Department of Clinical Sciences (D.Y.), and Department of Anatomy and Cell Biology (M.F.B.), Lewis Katz School of Medicine, Temple University, Philadelphia, PA; Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, OH (D.V., R.J.V., J.D.M.); Department of Pediatrics, Drexel University College of Medicine, Philadelphia, PA (A.T.); Howard Hughes Medical Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH (J.D.M.); and Department of Internal Medicine, University of California San Diego Medical Center, San Diego, CA (J.M.D.).
Tao WangFrom the Cardiovascular Research Center (M.W., J.M.D., S.M., C.D.T., G.B., P.G., D.M.T., H.K., T.E.S., S.C.H., M.A.V., T.S., E.A.F., R.M.B., T.W., S.R.H.), Department of Clinical Sciences (D.Y.), and Department of Anatomy and Cell Biology (M.F.B.), Lewis Katz School of Medicine, Temple University, Philadelphia, PA; Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, OH (D.V., R.J.V., J.D.M.); Department of Pediatrics, Drexel University College of Medicine, Philadelphia, PA (A.T.); Howard Hughes Medical Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH (J.D.M.); and Department of Internal Medicine, University of California San Diego Medical Center, San Diego, CA (J.M.D.).
Mary F BarbeFrom the Cardiovascular Research Center (M.W., J.M.D., S.M., C.D.T., G.B., P.G., D.M.T., H.K., T.E.S., S.C.H., M.A.V., T.S., E.A.F., R.M.B., T.W., S.R.H.), Department of Clinical Sciences (D.Y.), and Department of Anatomy and Cell Biology (M.F.B.), Lewis Katz School of Medicine, Temple University, Philadelphia, PA; Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, OH (D.V., R.J.V., J.D.M.); Department of Pediatrics, Drexel University College of Medicine, Philadelphia, PA (A.T.); Howard Hughes Medical Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH (J.D.M.); and Department of Internal Medicine, University of California San Diego Medical Center, San Diego, CA (J.M.D.).
Jeffrey D MolkentinFrom the Cardiovascular Research Center (M.W., J.M.D., S.M., C.D.T., G.B., P.G., D.M.T., H.K., T.E.S., S.C.H., M.A.V., T.S., E.A.F., R.M.B., T.W., S.R.H.), Department of Clinical Sciences (D.Y.), and Department of Anatomy and Cell Biology (M.F.B.), Lewis Katz School of Medicine, Temple University, Philadelphia, PA; Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, OH (D.V., R.J.V., J.D.M.); Department of Pediatrics, Drexel University College of Medicine, Philadelphia, PA (A.T.); Howard Hughes Medical Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH (J.D.M.); and Department of Internal Medicine, University of California San Diego Medical Center, San Diego, CA (J.M.D.).
Steven R HouserFrom the Cardiovascular Research Center (M.W., J.M.D., S.M., C.D.T., G.B., P.G., D.M.T., H.K., T.E.S., S.C.H., M.A.V., T.S., E.A.F., R.M.B., T.W., S.R.H.), Department of Clinical Sciences (D.Y.), and Department of Anatomy and Cell Biology (M.F.B.), Lewis Katz School of Medicine, Temple University, Philadelphia, PA; Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, OH (D.V., R.J.V., J.D.M.); Department of Pediatrics, Drexel University College of Medicine, Philadelphia, PA (A.T.); Howard Hughes Medical Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH (J.D.M.); and Department of Internal Medicine, University of California San Diego Medical Center, San Diego, CA (J.M.D.). srhouser@temple.edu.
Howard Hughes Medical Institute · USCincinnati Children's Hospital Medical Center · USUniversity of Cincinnati · USDrexel University · US
Funding
Targeted Cancer Therapeutics and Heart Failure: Mechanisms and Post-injury RepairP01HL091799 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI KOCH, WALTER J. · 2008 to 2018
$23.1MPKC alpha as a translational target in Heart FailureP01HL108806 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI RABINOWITZ, JOSEPH E · 2012 to 2016
$11.3MCalcium and Cardiac Regeneration after Myocardial InfarctionR01HL033921 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI HOUSER, STEVEN R · 1985 to 2017
$5.6MIntegrative Cardiovascular PathophysiologyT32HL091804 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI ELROD, JOHN WILLIAM · 2008 to 2024
$4.5MCalcium as a Molecular Signal in the HeartR01HL089312 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI HOUSER, STEVEN R · 2007 to 2011
$3.7MTRPC Channel Regulation of Cardiac Hypertrophy and ContractilityR01HL119229 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI HOUSER, STEVEN R · 2014 to 2017
$1.1MNHLBI NIH HHS P01 HL091799NHLBI NIH HHS P01 HL108806NHLBI NIH HHS R01 HL033921NHLBI NIH HHS R01 HL089312NHLBI NIH HHS R01 HL119229NHLBI NIH HHS T32 HL091804
Abstract
rationaleCatecholamines increase cardiac contractility, but exposure to high concentrations or prolonged exposures can cause cardiac injury. A recent study demonstrated that a single subcutaneous injection of isoproterenol (ISO; 200 mg/kg) in mice causes acute myocyte death (8%-10%) with complete cardiac repair within a month. Cardiac regeneration was via endogenous cKit(+) cardiac stem cell-mediated new myocyte formation.
objectiveOur goal was to validate this simple injury/regeneration system and use it to study the biology of newly forming adult cardiac myocytes. METHODS AND
resultsC57BL/6 mice (n=173) were treated with single injections of vehicle, 200 or 300 mg/kg ISO, or 2 daily doses of 200 mg/kg ISO for 6 days. Echocardiography revealed transiently increased systolic function and unaltered diastolic function 1 day after single ISO injection. Single ISO injections also caused membrane injury in ≈10% of myocytes, but few of these myocytes appeared to be necrotic. Circulating troponin I levels after ISO were elevated, further documenting myocyte damage. However, myocyte apoptosis was not increased after ISO injury. Heart weight to body weight ratio and fibrosis were also not altered 28 days after ISO injection. Single- or multiple-dose ISO injury was not associated with an increase in the percentage of 5-ethynyl-2'-deoxyuridine-labeled myocytes. Furthermore, ISO injections did not increase new myocytes in cKit(+/Cre)×R-GFP transgenic mice.
conclusionsA single dose of ISO causes injury in ≈10% of the cardiomyocytes. However, most of these myocytes seem to recover and do not elicit cKit(+) cardiac stem cell-derived myocyte regeneration.
Indexed as
AnimalsCatecholaminesIsoproterenolMaleMiceMice, Inbred C57BLMice, TransgenicMyocytes, CardiacRegenerationCatecholaminesIsoproterenolcatecholaminedrugheart failuremyocardiumremodeling
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.