SynthesisNeuroscience and biobehavioral reviews2016
Adolescent brain development and depression: A case for the importance of connectivity of the anterior cingulate cortex.
Synthesis in Neuroscience and biobehavioral reviews, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07173608 (Transforming Adolescent Perception and Mental Health Through Meditation and Cognitive Reappraisal A Mixed Method Study), which is not on this map. Cited by 73 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Transforming Adolescent Perception and Mental Health Through Meditation and Cognitive Reappraisal A Mixed Method Study
Who cites it
73 citing papers in PubMed, 2 syntheses or guidelines pooled it, 135 citations in OpenAlex.
- Genetics, epigenetics, and neurobiology of childhood-onset depression: an umbrella review.Molecular psychiatry · 2024Pooled it
- A meta-analytic investigation of grey matter differences in anorexia nervosa and autism spectrum disorder.European eating disorders review : the journal of the Eating Disorders Association · 2022Pooled it
- Aerobic exercise impacts the anterior cingulate cortex in adolescents with subthreshold mood syndromes: a randomized controlled trial study.Translational psychiatry · 2020Trial
- Brain and behavioral correlates of insulin resistance in youth with depression and obesity.Hormones and behavior · 2019Trial
- Adolescents' ventral striatal reward neural activity moderates the association between lifetime trauma exposure and lower depression after 6 months.European journal of psychotraumatology · 2026Article
- Being praised and criticized in adolescents and adults: Age-related changes in neural responses to social evaluations.Developmental cognitive neuroscience · 2026Article
- Directionality of longitudinal associations between frontostriatal structural connectivity and depressive symptoms in adolescent girls.Journal of child psychology and psychiatry, and allied disciplines · 2026Article
- Exploring Longitudinal Associations Among Error-Related Negativity, Perception of Interpersonal Events, and Internalizing Symptoms in Female Adolescents.Research on child and adolescent psychopathology · 2026Article
- Anterior Cingulate Cortex Reactivity to Social Stimuli Marks Individual Differences to Peer Victimization on Internalizing Symptoms in Adolescence.JAACAP open · 2026Article
- Depression in Chinese adolescents: prevalence, symptoms, risk factors, affected brain, diagnosis, and interventions.Frontiers in psychology · 2026Review
- Regional brain morphology and current antidepressant use: findings from 32 international cohorts from the ENIGMA major depressive disorder working group.Molecular psychiatry · 2025Article
- Role of the rostral anterior cingulate cortex in emotion processing in Treatment Resistant Depression.Translational psychiatry · 2025Article
- Human amygdala nuclei show distinct developmental trajectories from adolescence to adulthood in functional integration with prefrontal circuitry.Cell reports · 2025Article
- Maltreatment effects on cognitive control functional connectivity across adolescence: Prospective links to young adult mental health.Development and psychopathology · 2025Article
- Identifying neurobiological markers as predictors of antidepressant treatment using diffusion tensor imaging: A tract-based spatial statistical analysis of cingulate bundle.CNS spectrums · 2025Article
- Associations among socioeconomic disadvantage, longitudinal changes in within-network connectivity, and academic outcomes in the ABCD study.Developmental cognitive neuroscience · 2025Article
- Resting-state fMRI reveals altered functional connectivity associated with resilience and susceptibility to chronic social defeat stress in mouse brain.Molecular psychiatry · 2025Article
- Narrative Review: A Neurobiological Perspective on Resilience in Youth.JAACAP open · 2025Review
- Disruption of Multimodal Brain Networks and Structural-Functional Coupling in Adolescents with Major Depressive Disorder.Neuropsychiatric disease and treatment · 2025Article
- Family and parenting factors are associated with emotion regulation neural function in early adolescent girls with elevated internalizing symptoms.European child & adolescent psychiatry · 2024Article
13 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
We propose that structural and functional connectivity of the anterior cingulate cortex (ACC) represents a critical component of adolescent developmental psychopathology. We hypothesize that connectivity of the ACC, a hub for integrating cognitive, affective, and social information to guide self-regulation across domains, supports adaptive development of self-regulation during adolescence and that, conversely, disrupted maturation of ACC connectivity contributes to the development of depression. To integrate findings on typical development, we report results of a meta-analysis of diffusion imaging findings of typical adolescent development of the cingulum and anterior thalamic radiations, the tracts most relevant to ACC connectivity, and provide a critical review of the literature on ACC functional connectivity. Finally, we review the evidence for altered structural and functional connectivity in adolescents with depression. Although the evidence for our claim is persuasive, a more comprehensive understanding of the ACC's role depends upon future investigations with sophisticated modeling of networks, prospective and longitudinal designs, and examination of structure-function associations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.