ArticleScientific reports2016
High-contrast X-ray micro-radiography and micro-CT of ex-vivo soft tissue murine organs utilizing ethanol fixation and large area photon-counting detector.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 50 citations in OpenAlex.
- Detailed microCT imaging protocol for ex vivo rat stomachs with comparative analysis.Scientific reports · 2025Article
- The use of ethanol as contrast enhancer in synchrotron X-ray phase-contrast imaging leads to heterogeneous myocardial tissue shrinkage: a case report.Journal of synchrotron radiation · 2025Article
- Article
- Phase contrast micro-CT with adjustable in-slice spatial resolution at constant magnification.Physics in medicine and biology · 2024Article
- Optimal Agents for Visualizing Collagen Tissue Microarchitecture Using Contrast-Enhanced MicroCT.Pharmaceuticals (Basel, Switzerland) · 2023Review
- An optimized workflow for microCT imaging of formalin-fixed and paraffin-embedded (FFPE) early equine embryos.Anatomia, histologia, embryologia · 2022Article
- Brain virtual histology with X-ray phase-contrast tomography Part I: whole-brain myelin mapping in white-matter injury models.Biomedical optics express · 2022Article
- A Transparent Nano-Polycrystalline ZnWOACS omega · 2021Article
- A quality optimization approach to image Achilles tendon microstructure by phase-contrast enhanced synchrotron micro-tomography.Scientific reports · 2021Article
- X-ray microtomosynthesis of unstained pathology tissue samples.Journal of microscopy · 2021Article
- High resolution 3D visualization of the spinal cord in a post-mortem murine model.Biomedical optics express · 2020Article
- Phosphotungstic acid-enhanced microCT: Optimized protocols for embryonic and early postnatal mice.Developmental dynamics : an official publication of the American Association of Anatomists · 2020Article
- Image quality assessment of a photon counting detector in x-ray projection imaging.Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment · 2019Article
- The role of three-dimensionality and alveolar pressure in the distribution and amplification of alveolar stresses.Scientific reports · 2019Article
- Ethanol fixation method for heart and lung imaging in micro-CT.Japanese journal of radiology · 2019Article
- 3D vessel-wall virtual histology of whole-body perfused mice using a novel heavy element stain.Scientific reports · 2019Article
- Imaging of Mouse Brain Fixated in Ethanol in Micro-CT.BioMed research international · 2019Article
- Noninvasive allergic sinus congestion and resolution assessments using microcomputed tomography imaging.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Article
- 3D multiscale imaging of human vocal folds using synchrotron X-ray microtomography in phase retrieval mode.Scientific reports · 2018Article
- Correlative Detection of Isolated Single and Multi-Cellular Calcifications in the Internal Elastic Lamina of Human Coronary Artery Samples.Scientific reports · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Using dedicated contrast agents high-quality X-ray imaging of soft tissue structures with isotropic micrometre resolution has become feasible. This technique is frequently titled as virtual histology as it allows production of slices of tissue without destroying the sample. The use of contrast agents is, however, often an irreversible time-consuming procedure and despite the non-destructive principle of X-ray imaging, the sample is usually no longer usable for other research methods. In this work we present the application of recently developed large-area photon counting detector for high resolution X-ray micro-radiography and micro-tomography of whole ex-vivo ethanol-preserved mouse organs. The photon counting detectors provide dark-current-free quantum-counting operation enabling acquisition of data with virtually unlimited contrast-to-noise ratio (CNR). Thanks to the very high CNR even ethanol-only preserved soft-tissue samples without addition of any contrast agent can be visualized in great detail. As ethanol preservation is one of the standard steps of tissue fixation for histology, the presented method can open a way for widespread use of micro-CT with all its advantages for routine 3D non-destructive soft-tissue visualisation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.