ReviewParkinsonism & related disorders2016
Pharmacological treatment in Parkinson's disease: Effects on gait.
Review in Parkinsonism & related disorders, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07226284 (The Effects of Vagus Nerve Stimulation on Intrinsic Lower Leg Spinal Motoneuron Excitability in Parkinson's Disease.), which is not on this map. Cited by 98 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effects of Vagus Nerve Stimulation on Intrinsic Lower Leg Spinal Motoneuron Excitability in Parkinson's Disease.
Who cites it
98 citing papers in PubMed, 1 synthesis or guideline pooled it, 182 citations in OpenAlex.
- Effects of Oral Levodopa on Balance in People with Idiopathic Parkinson's Disease.Journal of Parkinson's disease · 2023Pooled it
- Visual perturbation training to reduce visual dependency in Parkinson's disease: A randomized controlled trial.PloS one · 2026Trial
- Changes in Gait Speed Vary Widely after the Use of Antiparkinson Medication in Persons with Parkinson's Disease.Movement disorders clinical practice · 2025Trial
- Transcranial Magnetic Stimulation Promotes Gait Training in Parkinson Disease.Annals of neurology · 2020Trial
- Cerebellar Perfusion Changes After Repetitive Deep Transcranial Magnetic Stimulation in Parkinson's Disease: A Five-Patient Case Series and Literature Review.Diagnostics (Basel, Switzerland) · 2026Article
- Effect of continuous subcutaneous foslevodopa/foscarbidopa infusion on gait in advanced Parkinson's disease: a real-world wearable-based study.Journal of neurology · 2026Article
- Cortico-pallidal beta dynamics underlie impaired turning in Parkinson's disease.NPJ Parkinson's disease · 2026Article
- Deep learning for freezing of gait assessment using inertial measurement units: a multicentre validation study.NPJ Parkinson's disease · 2026Article
- Is levodopa induced freezing of gait a paradox or an expected phenomenon?: a clinico-pathophysiological hypothesis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Review
- Deep brain stimulation reduces subthalamic nucleus pathological dynamics and rescues gait deficits associated with dopamine loss.bioRxiv : the preprint server for biology · 2026Article
- Utility of gait biomarkers in screening for obstructive sleep apnea among patients with Parkinson's disease: a cross-sectional study.BMC neurology · 2026Article
- Sarcopenia, body composition, physical performance, and clinical features in Parkinson's disease: a cross-sectional comparative study.Frontiers in endocrinology · 2026Article
- Knowledge structure and frontier trends of exercise interventions for Parkinson's disease: a bibliometric and visualized analysis.Frontiers in aging neuroscience · 2026Review
- Article
- Effects of anti-parkinsonian medication on gait during internal and external rhythmic auditory cueing in PD.Frontiers in human neuroscience · 2026Article
- The Effects of Repetitive Transcranial Magnetic Stimulation on Gait, Motor Function, and Balance in Parkinson's Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Journal of clinical medicine · 2025Review
- Effects of Exercise on Balance, Gait Speed, Quality of Life, and Symptom Relief Among Older Adults with Parkinson's Disease: A Meta-Analysis of Randomized Controlled Trials (RCTs).Healthcare (Basel, Switzerland) · 2025Review
- Characterizing Stair Ambulation Kinetics and the Effects of Dual Tasking in Parkinson's Disease.Journal of clinical medicine · 2025Article
- Differentiating Treatment-Resistant Depression With and Without Parkinsonism in the Elderly From a Psychiatric Perspective byInternational journal of geriatric psychiatry · 2025Article
- Article
38 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Gait impairments are a hallmark of Parkinson's disease (PD), both as early symptom and an important cause of disability later in the disease course. Although levodopa has been shown to improve gait speed and step length, the effect of dopamine replacement therapy on other aspects of gait is less well understood. In fact, falls are not reduced and some aspects of postural instability during gait are unresponsive to dopaminergic treatment. Moreover, many medications other than dopaminergic agents, can benefit or impair gait in people with PD. We review the effects of pharmacological interventions used in PD on gait, discriminating, whenever possible, among effects on four components of everyday mobility: straight walking, gait initiation, turning, gait adaptability. Additionally, we summarize the effects on freezing of gait. There is substantial evidence for improvement of spatial characteristics of simple, straight-ahead gait with levodopa and levodopa-enhancing drugs. Recent work suggests that drugs aiming to enhance the acetylcholine system might improve gait stability measures. There is a lack of well-designed studies to evaluate effects on more complex, but highly relevant walking abilities such as turning and making flexible adjustments to gait. Finally, paucity in the literature exists on detrimental effects of drugs used in PD that are known to worsen gait and postural stability in the elderly population.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.