ArticleScientific reports2016
Wrinkling Non-Spherical Particles and Its Application in Cell Attachment Promotion.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 62 citations in OpenAlex.
- Silk-coated PLGA non-spherical microparticles for simvastatin delivery in rat maxillofacial bone regeneration.Regenerative biomaterials · 2026Article
- Immiscible Phase Separation-Driven Microfabrication of Gelatin Methacryloyl Scaffolds for BMP-2 Delivery and Osteogenic Enhancement.Macromolecular bioscience · 2025Article
- Precise nanoscale fabrication technologies, the "last mile" of medicinal development.Acta pharmaceutica Sinica. B · 2025Review
- Lab on a Particle Technologies.Analytical chemistry · 2024Review
- Surface-Modified Inhaled Microparticle-Encapsulated Celastrol for Enhanced Efficacy in Malignant Pleural Mesothelioma.International journal of molecular sciences · 2023Article
- Emulsion-templated microparticles with tunable stiffness and topology: Applications as edible microcarriers for cultured meat.Biomaterials · 2022Article
- Fabrication of biodegradable particles with tunable morphologies by the addition of resveratrol to oil in water emulsions.International journal of pharmaceutics · 2020Article
- Bioinspired Multiscale Wrinkling Patterns on Curved Substrates: An Overview.Nano-micro letters · 2020Review
- Influence of Extracellular Mimicked Hierarchical Nano-Micro-Topography on the Bacteria/Abiotic Interface.Polymers · 2020Article
- Biointerface topography mediates the interplay between endothelial cells and monocytes.RSC advances · 2020Article
- Planar and Cell Aggregate-Like Assemblies Consisting of Microreactors and HepG2 Cells.ACS omega · 2017Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Surface wrinkled particles are ubiquitous in nature and present in different sizes and shapes, such as plant pollens and peppercorn seeds. These natural wrinkles provide the particles with advanced functions to survive and thrive in nature. In this work, by combining flow lithography and plasma treatment, we have developed a simple method that can rapidly create wrinkled non-spherical particles, mimicking the surface textures in nature. Due to the oxygen inhibition in flow lithography, the non-spherical particles synthesized in a microfluidic channel are covered by a partially cured polymer (PCP) layer. When exposed to plasma treatment, this PCP layer rapidly buckles, forming surface-wrinkled particles. We designed and fabricated various particles with desired shapes and sizes. The surfaces of these shapes were tuned to created wrinkle morphologies by controlling UV exposure time and the washing process. We further demonstrated that wrinkles on the particles significantly promoted cell attachment without any chemical modification, potentially providing a new route for cell attachment for various biomedical applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.