Evidence map›Paper›PMID 27461523›Full record

Trial reportMolecular nutrition & food research2017

Dietary supplementation with rice bran or navy bean alters gut bacterial metabolism in colorectal cancer survivors.

Amy M Sheflin, Erica C Borresen, Jay S Kirkwood, Claudia M Boot, Alyssa K Whitney, Shen Lu, Regina J Brown, Corey D Broeckling, Elizabeth P Ryan, Tiffany L Weir

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Molecular nutrition & food research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01929122 (BENEFIT), which is not on this map. Cited by 63 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 2 pooled it
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01929122 nacompletednot on this map

BENEFIT: Beans/Bran Enriching Nutritional Eating For Intestinal Health Trial

TypeinterventionalSponsorColorado State UniversityRan2010 to 2014Enrolled29ConditionsColorectal Cancer Control and PreventionArmsPlacebo-Control Meals and Snacks, Cooked Navy Bean Powder Meals and Snacks, Rice Bran Meals and Snacks
3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 2 syntheses or guidelines pooled it, 115 citations in OpenAlex.

  1. Impacts of Lifestyle and Microbiota-Targeted Interventions for Overweight and Obesity on the Human Gut Microbiome: A Systematic Review.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026
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3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Amy M SheflinDepartment of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO, USA.
Erica C BorresenDepartment of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, USA.
Jay S KirkwoodProteomics and Metabolomics Facility, Colorado State University, Fort Collins, CO, USA.
Claudia M BootDepartment of Chemistry, Central Instrument Facility, Colorado State University, Fort Collins, CO, USA.
Alyssa K WhitneyDepartment of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO, USA.
Shen LuDepartment of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO, USA.
Regina J BrownDepartment of Medicine, Division of Medical Oncology, University of Colorado Denver and Lone Tree Oncology affiliation of University of Colorado Cancer Center, Aurora, Colorado, USA.
Corey D BroecklingProteomics and Metabolomics Facility, Colorado State University, Fort Collins, CO, USA.
Elizabeth P RyanDepartment of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, USA.
Tiffany L WeirDepartment of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO, USA.
Colorado State University · USUniversity of Colorado Denver · US

Funding

Dietary Rice Bran Phytochemicals and Microbial Metabolites for Colon ChemopreventR21CA161472 · NCI · COLORADO STATE UNIVERSITY · PI RYAN, ELIZABETH P, WEIR, TIFFANY L · 2012 to 2013
$339k
NCI NIH HHS R21 CA161472
6 · The paper itself

Abstract

scopeHeat-stabilized rice bran (SRB) and cooked navy bean powder (NBP) contain a variety of phytochemicals that are fermented by colonic microbiota and may influence intestinal health. Dietary interventions with these foods should be explored for modulating colorectal cancer risk. METHODS AND

resultsA randomized-controlled pilot clinical trial investigated the effects of eating SRB (30 g/day) or cooked navy bean powder (35 g/day) on gut microbiota and metabolites (NCT01929122). Twenty-nine overweight/obese volunteers with a prior history of colorectal cancer consumed a study-provided meal and snack daily for 28 days. Volunteers receiving SRB or NBP showed increased gut bacterial diversity and altered gut microbial composition at 28 days compared to baseline. Supplementation with SRB or NBP increased total dietary fiber intake similarly, yet only rice bran intake led to a decreased Firmicutes:Bacteroidetes ratio and increased SCFA (propionate and acetate) in stool after 14 days but not at 28 days.

conclusionThese findings support modulation of gut microbiota and fermentation byproducts by SRB and suggest that foods with similar ability to increase dietary fiber intake may not have equal effects on gut microbiota and microbial metabolism.

Indexed as

Dietary SupplementsOryzaAdultAgedAged, 80 and overColorectal NeoplasmsFecesFemaleGastrointestinal MicrobiomeHumansMaleMiddle AgedSurvivorsBile acidsHeat-stabilized rice branNavy beanShort chain fatty acidsStool microbiota

Identifiers

PMID27461523
PMCPMC5209300
OpenAlexW2492738817

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.