ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2017
Mediterranean diet, micronutrients and macronutrients, and MRI measures of cortical thickness.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04606420 (Lifestyle Intervention for Early Alzheimer's Disease), which is not on this map. Cited by 69 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Lifestyle Intervention for Early Alzheimer's Disease
Who cites it
69 citing papers in PubMed, 5 syntheses or guidelines pooled it, 149 citations in OpenAlex.
- Fish consumption and brain structure: a comprehensive systematic review of observational studies.Aging clinical and experimental research · 2026Pooled it
- Research progress and hotspots of the impact of Mediterranean diet on brain health from 2005 to 2025: a bibliometric and visualization analysis.Frontiers in nutrition · 2026Pooled it
- A bibliometric analysis of the Mediterranean diet in metabolic syndrome (2015-2025).Frontiers in nutrition · 2026Pooled it
- Impact of α-Linolenic Acid, the Vegetable ω-3 Fatty Acid, on Cardiovascular Disease and Cognition.Advances in nutrition (Bethesda, Md.) · 2022Pooled it
- Meat Consumption, Cognitive Function and Disorders: A Systematic Review with Narrative Synthesis and Meta-Analysis.Nutrients · 2020Pooled it
- A 20-week, randomized controlled trial to determine the efficacy of the Aging Well through Interaction and Scientific Education - Action Plan (AgeWISE-AP) program in older Veterans.BMC geriatrics · 2025Trial
- Trial
- Trial
- Effect of MIND diet intervention on cognitive performance and brain structure in healthy obese women: a randomized controlled trial.Scientific reports · 2022Trial
- Plant-Based Dietary Patterns and Neuroimaging Biomarkers of Brain Health: A Scoping Review of Observational and Interventional Evidence.American journal of lifestyle medicine · 2026Review
- Assessing the Roles of Aging, Estrogen, Nutrition, and Neuroinflammation in Women and Their Involvement in Alzheimer's Disease-A Narrative Overview.International journal of molecular sciences · 2026Review
- Association between high carbohydrate to dietary fiber ratio and risk of dementia in older adults: analysis from the UK biobank.BMC neurology · 2025Article
- Article
- Neuroprotective Role of Omega-3 Fatty Acids: Fighting Alzheimer's Disease.Molecules (Basel, Switzerland) · 2025Review
- Isoflavone intake is associated with longitudinal changes in hippocampal volume, but not total grey matter volume, in Japanese middle-aged and older community dwellers.European journal of nutrition · 2025Article
- Dietary inflammatory index and brain disorders: a Large Prospective Cohort study.Translational psychiatry · 2025Article
- Unveiling the therapeutic potential of natural products in Alzheimer's disease: insights fromFrontiers in pharmacology · 2025Review
- Article
- Impact of Maternal Environment and Inflammation on Fetal Neurodevelopment.Antioxidants (Basel, Switzerland) · 2024Review
- Associations of dietary patterns and longitudinal brain-volume change in Japanese community-dwelling adults: results from the national institute for longevity sciences-longitudinal study of aging.Nutrition journal · 2024Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
Abstract
introductionThe Mediterranean diet (MeDi) is associated with reduced risk of cognitive impairment, but it is unclear whether it is associated with better brain imaging biomarkers.
methodsAmong 672 cognitively normal participants (mean age, 79.8 years, 52.5% men), we investigated associations of MeDi score and MeDi components with magnetic resonance imaging measures of cortical thickness for the four lobes separately and averaged (average lobar).
resultsHigher MeDi score was associated with larger frontal, parietal, occipital, and average lobar cortical thickness. Higher legume and fish intakes were associated with larger cortical thickness: legumes with larger superior parietal, inferior parietal, precuneus, parietal, occipital, lingual, and fish with larger precuneus, superior parietal, posterior cingulate, parietal, and inferior parietal. Higher carbohydrate and sugar intakes were associated with lower entorhinal cortical thickness. DISCUSSION: In this sample of elderly persons, higher adherence to MeDi was associated with larger cortical thickness. These cross-sectional findings require validation in prospective studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.