ArticleDysphagia2016
Reflex Cough and Disease Duration as Predictors of Swallowing Dysfunction in Parkinson's Disease.
Article in Dysphagia, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 3 syntheses or guidelines pooled it, 72 citations in OpenAlex.
- Upper Airway Sensory Testing in Dysphagia - Implications for Clinical Practice and Future Research Directions.Dysphagia · 2025Pooled it
- Pooled it
- A comprehensive review of the diagnosis and treatment of Parkinson's disease dysphagia and aspiration.Expert review of gastroenterology & hepatology · 2020Pooled it
- Trial
- Characterization of Ethyl Butyrate-Induced Cough Before and After Breath Control Techniques in Healthy Adults.American journal of speech-language pathology · 2023Trial
- Article
- Alpha-Synuclein Lesions in the Peripheral Nervous System of the Larynx in Parkinson's Disease.Dysphagia · 2026Article
- Dysphagia and oropharyngeal bradykinesia in Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2025Review
- Association between Perceived Dysphagia Symptoms and Swallowing Physiology in Parkinson's Disease.Movement disorders clinical practice · 2025Article
- Effect of Elevation Training Mask on Swallowing Function in Individuals with Parkinson's Disease.Dysphagia · 2025Article
- Acoustic Features of Airway Protective Maneuvers as Biomarkers of Radiation-Associated Dysphagia and Penetration/Aspiration in Head and Neck Cancer Patients.Head & neck · 2025Article
- Treatment Acceptability and Satisfaction With Cough Skill Training in Parkinson's Disease: A Mixed-Methods Study.Journal of speech, language, and hearing research : JSLHR · 2025Article
- Dyspnea and dystussia in Parkinson's disease: patient-reported prevalence and determinants.Journal of neurology · 2025Article
- Correlation between voice intensity and swallowing function in subjects with Parkinson's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- Article
- Enhancing Cough Motor Learning in Parkinson's Disease Through Variable Practice During Skill Training.Movement disorders clinical practice · 2024Article
- Sensorimotor Cough Dysfunction in Cerebellar Ataxias.Cerebellum (London, England) · 2024Article
- Cough Correlates of Functional Swallow Outcomes in Atypical Parkinsonism.Movement disorders clinical practice · 2024Article
- Acoustic Analysis of Voluntary Coughs, Throat Clearings, and Induced Reflexive Coughs in a Healthy Population.Dysphagia · 2023Article
- Laryngeal symptoms related to motor phenotypes in Parkinson's disease: A systematic review.Laryngoscope investigative otolaryngology · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Patients with Parkinson's disease (PD) have progressive and pervasive disorders of airway protection. Recent work has highlighted the relationship between reflex and voluntary cough and swallowing safety. The goal of this study was to test the sensitivity and specificity of several airway protective and disease-specific factors for predicting swallowing safety outcomes in PD. Sixty-four participants (44 males) completed measures of voluntary and reflex cough, and swallowing safety. Clinical predictors included disease severity and duration, and cough airflow and sensitivity measures. ROC and Chi-square analyses identified predictors of swallowing safety (penetration-aspiration score) in PD. Disease duration significantly discriminated between patients with normal and abnormal swallowing safety (p = 0.027, sensitivity: 71 %, specificity: 55.4 %). Cough reflex sensitivity significantly discriminated between patients who penetrated above the level of the vocal folds and those with more severe penetration/aspiration (p = 0.021, sensitivity: 71.0 %, specificity 57.6 %). Urge-to-cough sensitivity (log-log linear slope) was the only variable which significantly discriminated between patients with penetration versus aspiration (p = 0.017, sensitivity: 85.7 %, specificity 73.2 %). It is important to identify the factors which influence airway protective outcomes in PD especially given that aspiration pneumonia is a leading cause of death. Results from this study highlight the ecological validity of reflex cough in the study of airway protection and this study further identifies important factors to consider in the screening of airway protective deficits in PD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.