ArticleBMC neurology2016
Association between vertebral artery hypoplasia and posterior circulation stroke.
Article in BMC neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Anatomy of vertebral artery hypoplasia and its relationship with clinical implications: a systematic review and meta-analysis of prevalence.Surgical and radiologic anatomy : SRA · 2024Pooled it
- Vertebral Artery Hypoplasia and Posterior Circulation Vulnerability: A Systematic Review of Epidemiological, Hemodynamic, and Clinical Evidence.Neurology international · 2026Review
- Article
- The association between vertebral artery hypoplasia and fetal-type variants of the posterior cerebral artery with imaging findings among patients with posterior circulation stroke: A single-center cross-sectional study.Health science reports · 2024Article
- Medullary branches of the vertebral artery: microsurgical anatomy and clinical significance.Acta neurochirurgica · 2023Article
- The Vertebral Artery: A Systematic Review and a Meta-Analysis of the Current Literature.Diagnostics (Basel, Switzerland) · 2023Review
- Morphometric evaluation of cerebellar lobules in individuals with unilateral vertebral artery hypoplasia.Surgical and radiologic anatomy : SRA · 2023Article
- Acute Distal Vertebral Artery Occlusion in Patients with Asymmetrical Vertebral Artery Geometry: Role of Black-Blood-Enhanced MR Imaging.Diagnostics (Basel, Switzerland) · 2022Article
- Clinical Characteristics of Patients with Vertebral Artery Hypoplasia.International journal of environmental research and public health · 2022Article
- Effect of haemodynamics on the risk of ischaemic stroke in patients with severe vertebral artery stenosis.Stroke and vascular neurology · 2022Article
- Vertebral artery hypoplasia as an independent risk factor of posterior circulation atherosclerosis and ischemic stroke.Medicine · 2021Article
- Radiological anatomy of the intracranial vertebral artery in a select South African cohort of patients.Scientific reports · 2021Observational
- An anatomical investigation of the proximal vertebral arteries (V1, V2) in a select South African population.Surgical and radiologic anatomy : SRA · 2021Observational
- Vertebral artery hypoplasia influences age-related differences in blood flow of the large intracranial arteries.Aging brain · 2021Article
- Association between the posterior part of the circle of Willis and the vertebral artery hypoplasia.PloS one · 2019Article
- Endovascular treatment for atherosclerotic stenosis within V3 segment of a hypoplastic vertebral artery: Case report.Medicine · 2018Article
- Evaluation of BPPV with vertebral artery values.Neuropsychiatric disease and treatment · 2018Article
- Increased risk for posterior circulation ischaemia in patients with vertebral artery hypoplasia: A systematic review and meta-analysis.European stroke journal · 2017Article
- Interaction between vertebral artery hypoplasia and circle of Willis variants in posterior circulation stroke and TIA.Frontiers in neurologyArticle
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe clinical significance of vertebral artery (VA) hypoplasia is under discussion. The aim of this retrospective study is to evaluate a hypothesis of a possible causal link between VA hypoplasia (VAH) and the incidence of posterior circulation stroke (PCS) or TIA depending on the degree of VAH and vascular risk factors.
methodsA total of 367 symptomatic (PCS or TIA) and 742 asymptomatic subjects, were selected to participate in the study. The extracranial arteries were examined by ultrasound. VAH was defined as VA diameter in entire course <3 mm, although different degrees of VAH were examined. All the symptomatic patients underwent MRI or CT and MRA or CTA. The study assessed all the subjects in terms of their age, gender, co-risk factors (hypertension, hyperlipidemia, diabetes mellitus, peripheral arterial diseases, atrial fibrillation, myocardial infarction), as well as height of 180 healthy volunteers.
resultsVAH, regardless of the degree of severity, was more frequent in patients with non-cardioembolic PCS or TIA rather than in asymptomatic patients. The increasing degree of hypoplasia in patients under 65 years of age was a predictor of PCS/TIA, OR = 1.8, 95% CI: 1.3-2.5; p < 0.001. In subjects older than 65 years of age, this association failed. Only in patients aged under 50, VAH was significantly more frequent in the TIA group rather than in the PCS group (68.2% and 50%, respectively; p = 0.047). The optimal VA diameter cutoff point separating PCS/TIA and asymptomatic group was 2.7 mm. This value may vary in different populations, because VA diameter showed a significant dependence on sex as well as anthropometric parameters (height). With the increasing degree of VAH, the likelihood of the occurrence of the distal VA part stenosis/occlusion was growing (OR = 1.6, 95% CI: 1.2-2.1; p = 0.002). The distal VA stenosis/occlusion was likely to occur where the VA diameter was <2.2 mm.
conclusionsThe impact of the VAH on PCS/TIA and its pathogenetic mechanism was significantly influenced by age. The cutoff point of VA diameter, affecting the occurrence of PCS in different populations may vary because VA diameter depends on gender and anthropometric parameters (especially height).
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