ArticlePhysics in medicine and biology2016
A longitudinal magnetic resonance elastography study of murine brain tumors following radiation therapy.
Article in Physics in medicine and biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 34 citations in OpenAlex.
- Mechanobiology of the tumor microenvironment: a review of therapeutic interactions and in vitro elasticity measurement techniques.Journal of biomedical science · 2026Review
- Review
- Multiscale measurement of brain tissue and cell biomechanics using a mouse model.Biophysics reports · 2025Article
- The glioblastoma biomechanical landscape: A systematic review of magnetic resonance elastography (MRE) of brain tumors and healthy brain.APL bioengineering · 2025Review
- Assessment of Tumor Cell Invasion and Radiotherapy Response in Experimental Glioma by Magnetic Resonance Elastography.Journal of magnetic resonance imaging : JMRI · 2025Article
- Heterogeneous Mechanical Stress and Interstitial Fluid Flow Predictions Derived from DCE-MRI for Rat U251N Orthotopic Gliomas.Annals of biomedical engineering · 2024Article
- The Networking Brain: How Extracellular Matrix, Cellular Networks, and Vasculature Shape the In Vivo Mechanical Properties of the Brain.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- Tumor biomechanics as a novel imaging biomarker to assess response to immunotherapy in a murine glioma model.Scientific reports · 2024Article
- Wavelet MRE: Imaging propagating broadband acoustic waves with wavelet-based motion-encoding gradients.Magnetic resonance in medicine · 2024Article
- Article
- Preclinical Three-Dimensional Vibrational Shear Wave Elastography for Mapping of Tumour Biomechanical Properties In Vivo.Cancers · 2022Article
- Preliminary Findings on the Potential Use of Magnetic Resonance Elastography to Diagnose Lacunar Infarction.Neuropsychiatric disease and treatment · 2022Article
- A computational model of glioma reveals opposing, stiffness-sensitive effects of leaky vasculature and tumor growth on tissue mechanical stress and porosity.Biomechanics and modeling in mechanobiology · 2021Article
- Magnetic Resonance Elastography reveals effects of anti-angiogenic glioblastoma treatment on tumor stiffness and captures progression in an orthotopic mouse model.Cancer imaging : the official publication of the International Cancer Imaging Society · 2020Article
- REVIEW: MR elastography of brain tumors.NeuroImage. Clinical · 2020Review
- Soft Tissue Sarcoma Stiffness and Perfusion Evaluation by MRE and DCE-MRI for Radiation Therapy Response Assessment: A Technical Feasibility Study.Biomedical physics & engineering express · 2019Article
- Characterization of glioblastoma in an orthotopic mouse model with magnetic resonance elastography.NMR in biomedicine · 2018Article
- Pre-clinical MR elastography: Principles, techniques, and applications.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2018Review
- A novel method for rapid and quantitative mechanical assessment of soft tissue for diagnostic purposes: A computational study.International journal for numerical methods in biomedical engineering · 2018Article
- Magnetic Resonance Elastography of Rodent Brain.Frontiers in neurology · 2018Review
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
An accurate and noninvasive method for assessing treatment response following radiotherapy is needed for both treatment monitoring and planning. Measurement of solid tumor volume alone is not sufficient for reliable early detection of therapeutic response, since changes in physiological and/or biomechanical properties can precede tumor volume change following therapy. In this study, we use magnetic resonance elastography to evaluate the treatment effect after radiotherapy in a murine brain tumor model. Shear modulus was calculated and compared between the delineated tumor region of interest (ROI) and its contralateral, mirrored counterpart. We also compared the shear modulus from both the irradiated and non-irradiated tumor and mirror ROIs longitudinally, sampling four time points spanning 9-19 d post tumor implant. Results showed that the tumor ROI had a lower shear modulus than that of the mirror ROI, independent of radiation. The shear modulus of the tumor ROI decreased over time for both the treated and untreated groups. By contrast, the shear modulus of the mirror ROI appeared to be relatively constant for the treated group, while an increasing trend was observed for the untreated group. The results provide insights into the tumor properties after radiation treatment and demonstrate the potential of using the mechanical properties of the tumor as a biomarker. In future studies, more closely spaced time points will be employed for detailed analysis of the radiation effect.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.