Evidence map›Paper›PMID 27461371›Full record

ArticleThe Journal of physiology2017

Endocannabinoids control vesicle release mode at midbrain periaqueductal grey inhibitory synapses.

Karin R Aubrey, Geoffrey M Drew, Hyo-Jin Jeong, Benjamin K Lau, Christopher W Vaughan

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. CBeLife · 2020
    Article
  5. Review
  6. Article
  7. Review
  8. Periaqueductal Gray Glutamatergic Transmission Governs Chronic Stress-Induced Depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Karin R AubreyPain Management Research Institute, Kolling Institute of Medical Research, Northern Clinical School, The University of Sydney and Royal North Shore Hospital, St. Leonards, New South Wales, Australia.
Geoffrey M DrewPain Management Research Institute, Kolling Institute of Medical Research, Northern Clinical School, The University of Sydney and Royal North Shore Hospital, St. Leonards, New South Wales, Australia.
Hyo-Jin JeongPain Management Research Institute, Kolling Institute of Medical Research, Northern Clinical School, The University of Sydney and Royal North Shore Hospital, St. Leonards, New South Wales, Australia.
Benjamin K LauPain Management Research Institute, Kolling Institute of Medical Research, Northern Clinical School, The University of Sydney and Royal North Shore Hospital, St. Leonards, New South Wales, Australia.
Christopher W VaughanPain Management Research Institute, Kolling Institute of Medical Research, Northern Clinical School, The University of Sydney and Royal North Shore Hospital, St. Leonards, New South Wales, Australia.ORCID 0000-0003-4314-7689
Royal North Shore Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

key pointsThe midbrain periaqueductal grey (PAG) forms part of an endogenous analgesic system which is tightly regulated by the neurotransmitter GABA. The role of endocannabinoids in regulating GABAergic control of this system was examined in rat PAG slices. Under basal conditions GABAergic neurotransmission onto PAG output neurons was multivesicular. Activation of the endocannabinoid system reduced GABAergic inhibition by reducing the probability of release and by shifting release to a univesicular mode. Blockade of endocannabinoid system unmasked a tonic control over the probability and mode of GABA release. These findings provides a mechanistic foundation for the control of the PAG analgesic system by disinhibition. ABSTRACT: The midbrain periaqueductal grey (PAG) has a crucial role in coordinating endogenous analgesic responses to physiological and psychological stressors. Endocannabinoids are thought to mediate a form of stress-induced analgesia within the PAG by relieving GABAergic inhibition of output neurons, a process known as disinhibition. This disinhibition is thought to be achieved by a presynaptic reduction in GABA release probability. We examined whether other mechanisms have a role in endocannabinoid modulation of GABAergic synaptic transmission within the rat PAG. The group I mGluR agonist DHPG ((R,S)-3,5-dihydroxyphenylglycine) inhibited evoked IPSCs and increased their paired pulse ratio in normal external Ca

Indexed as

AnimalsCalciumEndocannabinoidsFemaleGABA Antagonistsgamma-Aminobutyric AcidInhibitory Postsynaptic PotentialsIn Vitro TechniquesMaleMethoxyhydroxyphenylglycolPeriaqueductal GrayPhosphinic AcidsPiperidinesPyrazolesPyridinesRats, Sprague-Dawley(1,2,5,6-tetrahydropyridin-4-yl)methylphosphinic acid3,4-dihydroxyphenylglycolAM 251CalciumEndocannabinoidsGABA Antagonistsgamma-Aminobutyric AcidMethoxyhydroxyphenylglycolPhosphinic AcidsPiperidinesPyrazolesPyridinesReceptors, Metabotropic Glutamateendocannabinoidgabamultivesicularpainsynaptic transmission

Identifiers

PMID27461371
PMCPMC5199746
OpenAlexW2493377233

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.