Evidence map›Paper›PMID 27461229›Full record

ArticleBMC public health2016

Incidence of tuberculosis among school-going adolescents in South India.

Dharma Rao Uppada, Sumithra Selvam, Nelson Jesuraj, Esther L Lau, T Mark Doherty, Harleen M S Grewal, Mario Vaz, Bernt Lindtjørn, TB Trials Study Group

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC public health, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 4 countries.

Dharma Rao UppadaDepartment of Pharmacology, Rangaraya Medical College, Kakinada, Andhra Pradesh, 533001, India. druppadajan13@gmail.com.ORCID 0000-0002-4615-465X
Sumithra SelvamSt. John's Research Institute, Bangalore, India.
Nelson JesurajFormerly at St. John's Research Institute, Bangalore, India.
Esther L LauAeras, Metro Area, Washington, DC, USA.
T Mark DohertyGSK Vaccines, Wavre, Belgium.
Harleen M S GrewalDepartment of Clinical Science, Infection, Faculty of Medicine and Dentistry, University of Bergen, Bergen, Norway.
Mario VazSt. John's Research Institute, Bangalore, India.
Bernt LindtjørnCentre for International Health, University of Bergen, Bergen, Norway.
TB Trials Study Group
Aeras · USRangaraya Medical College · INSt. John's National Academy of Health Sciences · INGlaxoSmithKline (Belgium) · BEHaukeland University Hospital · NOUniversity of Bergen · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTuberculosis (TB) incidence data in vaccine target populations, particularly adolescents, are important for designing and powering vaccine clinical trials. Little is known about the incidence of tuberculosis among adolescents in India. The objective of current study is to estimate the incidence of pulmonary tuberculosis (PTB) disease among adolescents attending school in South India using two different surveillance methods (active and passive) and to compare the incidence between the two groups.

methodsThe study was a prospective cohort study with a 2-year follow-up period. The study was conducted in Palamaner, Chittoor District of Andhra Pradesh, South India from February 2007 to July 2010. A random sampling procedure was used to select a subset of schools to enable approximately 8000 subjects to be available for randomization in the study. A stratified randomization procedure was used to assign the selected schools to either active or passive surveillance. Participants who met the criteria for being exposed to TB were referred to the diagnostic ward for pulmonary tuberculosis confirmation. A total number of 3441 males and 3202 females between the ages 11 and less than 18 years were enrolled into the study.

resultsOf the 3102 participants in the active surveillance group, four subjects were diagnosed with definite tuberculosis, four subjects with probable tuberculosis, and 71 subjects had non-tuberculous Mycobacteria (NTM) isolated from their sputum. Of the 3541 participants in the passive surveillance group, four subjects were diagnosed with definite tuberculosis, two subjects with probable tuberculosis, and 48 subjects had non-tuberculosis Mycobacteria isolated from their sputum. The incidence of definite + probable TB was 147.60 / 100,000 person years in the active surveillance group and 87 / 100,000 person years in the passive surveillance group.

conclusionThe incidence of pulmonary tuberculosis among adolescents in our study is lower than similar studies conducted in South Africa and Eastern Uganda - countries with a higher incidence of tuberculosis and human immunodeficiency virus (HIV) than India. The study data will inform sample design for vaccine efficacy trials among adolescents in India.

Indexed as

Population SurveillanceAdolescentChildFemaleFollow-Up StudiesHumansIncidenceIndiaMaleNontuberculous MycobacteriaProspective StudiesSchoolsSputumTuberculosis, PulmonaryAdolescentsPulmonary tuberculosisSouth IndiaTB incidenceTB vaccine trials

Identifiers

PMID27461229
PMCPMC4962501
OpenAlexW2507057277

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.