Evidence map›Paper›PMID 27461210›Full record

ArticleEuropean heart journal. Cardiovascular Imaging2017

Utility of adenosine stress perfusion CMR to assess paediatric coronary artery disease.

Hopewell N Ntsinjana, Oliver Tann, Marina Hughes, Graham Derrick, Aurelio Secinaro, Silvia Schievano, Vivek Muthurangu, Andrew M Taylor

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European heart journal. Cardiovascular Imaging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.

  1. SCMR Position Paper (2020) on clinical indications for cardiovascular magnetic resonance.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2020
    Guideline
  2. Review
  3. Article
  4. Review
  5. Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. SCMR expert consensus statement for cardiovascular magnetic resonance of acquired and non-structural pediatric heart disease.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2022
    Review
  16. Review
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Hopewell N NtsinjanaCentre for Cardiovascular Imaging, Institute of Cardiovascular Science, University College London, London, UK.
Oliver TannCentre for Cardiovascular Imaging, Institute of Cardiovascular Science, University College London, London, UK.
Marina HughesCentre for Cardiovascular Imaging, Institute of Cardiovascular Science, University College London, London, UK.
Graham DerrickCardiorespiratory Unit, Great Ormond Street Hospital for Children, NHS Foundation Trust, Level 7, Nurses Home, Great Ormond Street, London WC1N 3JH, UK.
Aurelio SecinaroDepartment of Imaging, Bambino Gesù Children's Hospital, Rome, Italy.
Silvia SchievanoCentre for Cardiovascular Imaging, Institute of Cardiovascular Science, University College London, London, UK.
Vivek MuthuranguCentre for Cardiovascular Imaging, Institute of Cardiovascular Science, University College London, London, UK.
Andrew M TaylorCentre for Cardiovascular Imaging, Institute of Cardiovascular Science, University College London, London, UK.
Great Ormond Street Hospital for Children NHS Foundation Trust · GBUniversity College London · GBBambino Gesù Children's Hospital · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsCardiovascular magnetic resonance (CMR), using adenosine stress perfusion and late-gadolinium enhancement (LGE), is becoming the 'gold standard' non-invasive imaging modality in the assessment of adults with coronary artery disease (CAD). However, despite its proved feasibility in paediatric patients, clinical utility has not been demonstrated. Therefore, this study aims to establish the role of adenosine stress perfusion CMR as a screening test in paediatric patients with acquired or congenital CAD. METHODS AND

resultsA total of 58 paediatric patients underwent 61 consecutive clinically indicated coronary artery assessments for diagnostic and clinical decision-making purposes. The diagnosis was based on X-ray or computed tomography coronary angiography for anatomy, adenosine stress CMR imaging for myocardial perfusion and LGE for tissue characterization. Two studies were aborted because of unwanted side effects of adenosine stress, thus 59 studies were completed in 56 patients [median age 14.1 years (interquartile range 10.9-16.2)]. When compared with coronary anatomical imaging, adenosine stress perfusion CMR performed as follows: sensitivity 100% (95% confidence interval, CI: 71.6-100%), specificity 98% (95% CI: 86.7-99.9%), positive predictive value (PPV) 92.9% (95% CI: 64.2-99.6%), and negative predictive value 100% (95% CI: 89.9-100%).

conclusionIn paediatric CAD, adenosine stress perfusion CMR imaging is adequate as an initial, non-invasive screening test for the identification of significant coronary artery lesions, with anatomical imaging used to confirm the extent of the culprit lesion.

Indexed as

AdenosineRadiographic Image EnhancementAdolescentChildChild, PreschoolCohort StudiesComputed Tomography AngiographyConfidence IntervalsCoronary AngiographyCoronary Artery DiseaseCoronary CirculationExercise TestFemaleHumansMagnetic Resonance Imaging, CineMaleAdenosineCardiovascular magnetic resonance imaging, Adenosine perfusion imagingCoronary artery diseasePaediatrics

Identifiers

PMID27461210
PMCPMC5837637
OpenAlexW2477632437

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.