ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2017
Reciprocal Catecholamine Changes during Opiate Exposure and Withdrawal.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 41 citations in OpenAlex.
- The Impact of Levetiracetam on Various Symptoms of Morphine Dependence in Mice.Life (Basel, Switzerland) · 2026Article
- Presynaptic Mu Opioid Receptors Suppress the Functional Connectivity of Ventral Tegmental Area Dopaminergic Neurons with Aversion-Related Brain Regions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- The Influence of Topiramate on Morphine Dependence in Mice.Biomolecules · 2025Article
- Transcriptional signatures of fentanyl use in the mouse ventral tegmental area.Addiction biology · 2024Article
- In Vitro and In Vivo Pharmacological Profiles of LENART01, a Dermorphin-Ranatensin Hybrid Peptide.International journal of molecular sciences · 2024Article
- Opioid withdrawal: role in addiction and neural mechanisms.Psychopharmacology · 2023Review
- Advances in the characterization of negative affect caused by acute and protracted opioid withdrawal using animal models.Neuropharmacology · 2023Review
- Adaptations in Nucleus Accumbens Neuron Subtypes Mediate Negative Affective Behaviors in Fentanyl Abstinence.Biological psychiatry · 2023Article
- Probing different paradigms of morphine withdrawal on sleep behavior in male and female C57BL/6J mice.bioRxiv : the preprint server for biology · 2023Article
- Wireless, Battery-Free Implants for Electrochemical Catecholamine Sensing and Optogenetic Stimulation.ACS nano · 2023Article
- Neuroplasticity of the extended amygdala in opioid withdrawal and prolonged opioid abstinence.Frontiers in pharmacology · 2023Review
- Noradrenergic circuits and signaling in substance use disorders.Neuropharmacology · 2022Review
- Neural bases for attenuation of morphine withdrawal by Heantos-4: role of l-tetrahydropalmatine.Scientific reports · 2020Article
- The Mechanisms Involved in Morphine Addiction: An Overview.International journal of molecular sciences · 2019Review
- Electrochemistry at the Synapse.Annual review of analytical chemistry (Palo Alto, Calif.) · 2019Review
- Diazepam Concurrently Increases the Frequency and Decreases the Amplitude of Transient Dopamine Release Events in the Nucleus Accumbens.The Journal of pharmacology and experimental therapeutics · 2018Article
- Removal of Differential Capacitive Interferences in Fast-Scan Cyclic Voltammetry.Analytical chemistry · 2017Article
- Hitchhiker's Guide to Voltammetry: Acute and Chronic Electrodes for in Vivo Fast-Scan Cyclic Voltammetry.ACS chemical neuroscience · 2017Review
- Contrasting Regulation of Catecholamine Neurotransmission in the Behaving Brain: Pharmacological Insights from an Electrochemical Perspective.Pharmacological reviews · 2017Review
- Medullary Norepinephrine Projections Release Norepinephrine into the Contralateral Bed Nucleus of the Stria Terminalis.ACS chemical neuroscience · 2016Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Dysregulated catecholamine signaling has long been implicated in drug abuse. Although much is known about adaptations following chronic drug administration, little work has investigated how a single drug exposure paired with withdrawal influences catecholamine signaling in vivo. We used fast-scan cyclic voltammetry in freely moving rats to measure real-time catecholamine overflow during acute morphine exposure and naloxone-precipitated withdrawal in two regions associated with the addiction cycle: the dopamine-dense nucleus accumbens (NAc) and norepinephrine-rich ventral bed nucleus of the stria terminalis (vBNST). We compared dopamine transients in the NAc with norepinephrine concentration changes in the vBNST, and correlated release with specific withdrawal-related behaviors. Morphine increased dopamine transients in the NAc, but did not elicit norepinephrine responses in the vBNST. Conversely, dopamine output was decreased during withdrawal, while norepinephrine was released in the vBNST during specific withdrawal symptoms. Both norepinephrine and withdrawal symptoms could be elicited in the absence of morphine by administering naloxone with an α
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.