ArticleClinical and experimental immunology2016
Latency for cytomegalovirus impacts T cell ageing significantly in elderly end-stage renal disease patients.
Article in Clinical and experimental immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- Vaccination in Children with Chronic Kidney Disease: Current Status and Perspectives.Vaccines · 2025Review
- Immunological features of ESRD patients undergoing hemodialysis of various ages.International urology and nephrology · 2024Article
- Changes in T and B cell subsets in end stage renal disease patients before and after kidney transplantation.Immunity & ageing : I & A · 2021Article
- Functional Consequences of Memory Inflation after Solid Organ Transplantation.Journal of immunology (Baltimore, Md. : 1950) · 2021Article
- Uremia-Associated Immunological Aging and Severity of COVID-19 Infection.Frontiers in medicine · 2021Review
- Association of Premature Immune Aging and Cytomegalovirus After Solid Organ Transplant.Frontiers in immunology · 2021Article
- Premature aging of circulating T cells predicts all-cause mortality in hemodialysis patients.BMC nephrology · 2020Article
- Molecular Mechanisms of Premature Aging in Hemodialysis: The Complex Interplay Between Innate and Adaptive Immune Dysfunction.International journal of molecular sciences · 2020Review
- T-cell aging in end-stage renal disease: an evolving story with CMV.Medical microbiology and immunology · 2019Review
- NK Cells Contribute to the Immune Risk Profile in Kidney Transplant Candidates.Frontiers in immunology · 2019Article
- pERK-dependent defective TCR-mediated activation of CD4Immunity & ageing : I & A · 2017Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The number of elderly patients with end-stage renal disease (ESRD) has increased significantly during the last decade. Elderly ESRD patients are vulnerable to infectious complications because of an aged immune system. Additional immunological ageing effects may be derived from the uraemic environment and cytomegalovirus (CMV) latency. Elderly patients may be affected by these factors in particular, but data in this age group are limited. To assess the degree of immunological ageing and proliferative capacity of T lymphocytes, 49 elderly ESRD patients (defined as aged ≥ 65 years) on the renal transplantation waiting list were recruited and compared to 44 elderly healthy individuals (HI), matched for age and CMV serostatus. CMV latency was associated with more highly differentiated CD4
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.