Evidence map›Paper›PMID 27460672›Full record

ReviewJournal of orthopaedic surgery and research2016

Matrix scaffolding for stem cell guidance toward skeletal muscle tissue engineering.

Claudia Fuoco, Lucia Lisa Petrilli, Stefano Cannata, Cesare Gargioli

Open access · goldAbstract readReview
In one paragraph

Review in Journal of orthopaedic surgery and research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
8.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 66 citations in OpenAlex.

  1. Article
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  14. Evaluation of the Therapeutic Potential of Human iPSCs in a Murine Model of VML.Molecular therapy : the journal of the American Society of Gene Therapy · 2021
    Article
  15. Article
  16. Review
  17. On the Interaction between 1D Materials and Living Cells.Journal of functional biomaterials · 2020
    Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Claudia FuocoDepartment of Biology, Rome University Tor Vergata, Rome, Italy.
Lucia Lisa PetrilliDepartment of Biology, Rome University Tor Vergata, Rome, Italy.
Stefano CannataDepartment of Biology, Rome University Tor Vergata, Rome, Italy.
Cesare GargioliDepartment of Biology, Rome University Tor Vergata, Rome, Italy. cesare.gargioli@uniroma2.it.
University of Rome Tor Vergata · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extracellular matrix (ECM) is composed of many types of fibrous structural proteins and glycosaminoglycans. This important cell component not only provides a support for cells but is also actively involved in cell-cell interaction, proliferation, migration, and differentiation, representing, therefore, no longer only a mere static structural scaffold for cells but rather a dynamic and versatile compartment. This aspect leads to the need for investigating new bio-inspired scaffolds or biomaterials, able to mimic ECM in tissue engineering. This new field of research finds particular employment in skeletal muscle tissue regeneration, due to the inability of this complex tissue to recover volumetric muscle loss (VML), after severe injury. Usually, this is the result of traumatic incidents, tumor ablations, or pathological states that lead to the destruction of a large amount of tissue, including connective tissue and basement membrane. Therefore, skeletal muscle tissue engineering represents a valid alternative to overcome this problem.Here, we described a series of natural and synthetic biomaterials employed as ECM mimics for their ability to recreate the correct muscle stem cell niche, by promoting myogenic stem cell differentiation and so, positively affecting muscle repair.

Indexed as

Tissue ScaffoldsAnimalsExtracellular MatrixHumansMuscle, SkeletalStem CellsTissue EngineeringTissue TransplantationBiomaterialsBiomimetic scaffoldExtracellular matrixSkeletal muscleTissue engineering

Identifiers

PMID27460672
PMCPMC4962357
OpenAlexW2505898780

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.