ArticleRadiation oncology (London, England)2016
Methodology for analysis and reporting patterns of failure in the Era of IMRT: head and neck cancer applications.
Article in Radiation oncology (London, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Mapping Local Failure Following Bladder Radiotherapy According to Dose.Clinical oncology (Royal College of Radiologists (Great Britain)) · 2022Trial
- Surgery followed by adjuvant radiotherapy versus definitive radiotherapy for locally advanced squamous cell carcinoma of the pharynx and larynx: a propensity score-matched analysis.Clinical and translational radiation oncology · 2027Article
- Predominance of In-Field Recurrence After Radiotherapy for Sinonasal Cancer: A Single-Center Retrospective Study.Head & neck · 2026Article
- Direct integration of deep learning-based GTV auto-segmentation into a clinical radiotherapy planning system.Physics and imaging in radiation oncology · 2026Article
- Outcomes and recurrence pattern analysis of intensity modulated chemoradiotherapy in nasopharyngeal cancer: a retrospective study from Heidelberg University Hospital.Radiation oncology (London, England) · 2025Article
- Sex-based differences in patients with locally advanced pharyngeal and laryngeal SCC treated with definitive or adjuvant radiotherapy.Radiation oncology (London, England) · 2025Article
- Combined Spatial and Dosimetric Recurrence Pattern Analysis in Head and Neck Squamous Cell Carcinoma Following Postoperative (Chemo)radiotherapy.Radiation oncology (London, England) · 2025Article
- A unified workflow for classifying patterns of locoregional failure using radiotherapy treatment planning dose distributions.BJR open · 2025Article
- Patterns of loco-regional progression and patient outcomes after definitive-dose radiation therapy for anaplastic thyroid cancer.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2025Article
- Patterns of failure for recurrent head and neck squamous cell carcinoma treated with salvage surgery and postoperative IMRT reirradiation.Clinical and translational radiation oncology · 2024Article
- Outcomes among oropharyngeal and oral cavity cancer patients treated with postoperative volumetric modulated arctherapy.Frontiers in oncology · 2023Article
- Estimated dose to site of loco-regional recurrence after radiotherapy in anal cancer using point of origin methods.Physics and imaging in radiation oncology · 2023Article
- Patterns of failure for hypopharynx cancer patients treated with limited high-dose radiotherapy treatment volumes.Radiation oncology journal · 2022Article
- Article
- Ways to unravel the clinical potential of carbon ions for head and neck cancer reirradiation: dosimetric comparison and local failure pattern analysis as part of the prospective randomized CARE trial.Radiation oncology (London, England) · 2022Article
- Combining Tumor Segmentation Masks with PET/CT Images and Clinical Data in a Deep Learning Framework for Improved Prognostic Prediction in Head and Neck Squamous Cell Carcinoma.Head and neck tumor segmentation and outcome prediction : second challenge, HECKTOR 2021, held in conjunction with MICCAI 2021, Strasbourg, France, September 27, 2021, Proceedings. Head and Neck Tumor Segmentation Challenge (2nd : 2021 ... · 2022Article
- Proton Therapy for Major Salivary Gland Cancer: Clinical Outcomes.International journal of particle therapy · 2021Article
- Clinical outcomes for larynx patients with cancer treated with refinement of high-dose radiation treatment volumes.Head & neck · 2020Article
- Stability analysis of CT radiomic features with respect to segmentation variation in oropharyngeal cancer.Clinical and translational radiation oncology · 2020Article
- Comparison of rigid and deformable image registration for nasopharyngeal carcinoma radiotherapy planning with diagnostic position PET/CT.Japanese journal of radiology · 2020Article
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Authors and funding
11 authors.
Funding
Abstract
backgroundThe aim of this study is to develop a methodology to standardize the analysis and reporting of the patterns of loco-regional failure after IMRT of head and neck cancer. MATERIAL AND
methodsTwenty-one patients with evidence of local and/or regional failure following IMRT for head-and-neck cancer were retrospectively reviewed under approved IRB protocol. Manually delineated recurrent gross disease (rGTV) on the diagnostic CT documenting recurrence (rCT) was co-registered with the original planning CT (pCT) using both deformable (DIR) and rigid (RIR) image registration software. Subsequently, mapped rGTVs were compared relative to original planning target volumes (TVs) and dose using a centroid-based approaches. Failures were then classified into five types based on combined spatial and dosimetric criteria; A (central high dose), B (peripheral high dose), C (central elective dose), D (peripheral elective dose), and E (extraneous dose).
resultsA total of 26 recurrences were identified. Using DIR, recurrences were assigned to more central TVs compared to RIR as detected using the spatial centroid-based method (p = 0.0002). rGTVs mapped using DIR had statistically significant higher mean doses when compared to rGTVs mapped rigidly (mean dose 70 vs. 69 Gy, p = 0.03). According to the proposed classification 22 out of 26 failures were of type A (central high dose) as assessed by DIR method compared to 18 out of 26 for the RIR because of the tendencey of RIR to assign failures more peripherally.
conclusionsRIR tends to assigns failures more peripherally. DIR-based methods showed that the vast majority of failures originated in the high dose target volumes and received full prescribed doses suggesting biological rather than technology-related causes of failure. Validated DIR-based registration is recommended for accurate failure characterization and a novel typology-indicative taxonomy is recommended for failure reporting in the IMRT era.
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