Evidence map›Paper›PMID 27460540›Full record

ArticleStatistical methods in medical research2018

Joint modeling of longitudinal zero-inflated count and time-to-event data: A Bayesian perspective.

Huirong Zhu, Stacia M DeSantis, Sheng Luo

Open access · greenAbstract read
In one paragraph

Article in Statistical methods in medical research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Huirong ZhuDepartment of Biostatistics, The University of Texas Health Science Center at Houston, Houston, USA.
Stacia M DeSantisDepartment of Biostatistics, The University of Texas Health Science Center at Houston, Houston, USA.
Sheng LuoDepartment of Biostatistics, The University of Texas Health Science Center at Houston, Houston, USA.
The University of Texas Health Science Center at Houston · US

Funding

Center for Clinical and Translational Sciences (CCTS)UL1TR000371 · NCATS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MCPHERSON, DAVID D · 2012 to 2016
$13.4M
Parkinson's Disease Clinical Trial: Statistical CenterU01NS043127 · NINDS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI LUO, SHENG · 2001 to 2015
$8.0M
Center for Clinical and Translational Sciences (CCTS)KL2TR000370 · NCATS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MCPHERSON, DAVID D · 2012 to 2016
$4.3M
Statistical Methods for Clinical Trials with Multivariate Longitudinal OutcomesR01NS091307 · NINDS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI LUO, SHENG · 2015 to 2018
$1.2M
Robust Transition Models for the Analysis of Longitudinal Drinking OutcomesR03AA020648 · NIAAA · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI BANDYOPADHYAY, DIPANKAR, DESANTIS, STACIA · 2011 to 2012
$160k
NCATS NIH HHS KL2 TR000370NCATS NIH HHS UL1 TR000371NIAAA NIH HHS R03 AA020648NINDS NIH HHS R01 NS091307NINDS NIH HHS U01 NS043127
6 · The paper itself

Abstract

Longitudinal zero-inflated count data are encountered frequently in substance-use research when assessing the effects of covariates and risk factors on outcomes. Often, both the time to a terminal event such as death or dropout and repeated measure count responses are collected for each subject. In this setting, the longitudinal counts are censored by the terminal event, and the time to the terminal event may depend on the longitudinal outcomes. In the study described herein, we expand the class of joint models for longitudinal and survival data to accommodate zero-inflated counts and time-to-event data by using a Cox proportional hazards model with piecewise constant baseline hazard. We use a Bayesian framework via Markov chain Monte Carlo simulations implemented in the BUGS programming language. Via an extensive simulation study, we apply the joint model and obtain estimates that are more accurate than those of the corresponding independence model. We apply the proposed method to an alpha-tocopherol, beta-carotene lung cancer prevention study.

Indexed as

Outcome Assessment, Health CareSurvival AnalysisBayes TheoremBiomedical ResearchLongitudinal StudiesMarkov ChainsMonte Carlo MethodPoisson Distributioncount dataJoint modelMarkov chain Monte Carlomixed modelzero-inflation generalized Poisson

Identifiers

PMID27460540
PMCPMC5269555
OpenAlexW2494572488

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.