Trial reportBMC oral health2016
An oral health optimized diet can reduce gingival and periodontal inflammation in humans - a randomized controlled pilot study.
Trial report in BMC oral health, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT06130189 (The Impact of Nutrition, Physical Activity Habits and Adherence to the Mediterranean Diet on Children's Oral Health), which is not on this map. Cited by 109 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Impact of Nutrition, Physical Activity Habits and Adherence to the Mediterranean Diet on Children's Oral Health
Who cites it
109 citing papers in PubMed, 6 syntheses or guidelines pooled it, 203 citations in OpenAlex.
- Role of Dietary Fibre in Managing Periodontal Diseases-A Systematic Review and Meta-Analysis of Human Intervention Studies.Nutrients · 2023Pooled it
- Could dietary restrictions affect periodontal disease? A systematic review.Clinical oral investigations · 2023Pooled it
- Dietary and Nutraceutical Interventions as an Adjunct to Non-Surgical Periodontal Therapy-A Systematic Review.Nutrients · 2023Pooled it
- Improving oral health in people with severe mental illness (SMI): A systematic review.PloS one · 2021Pooled it
- Effects of Short-Chain Fatty Acids on Human Oral Epithelial Cells and the Potential Impact on Periodontal Disease: A Systematic Review of In Vitro Studies.International journal of molecular sciences · 2020Pooled it
- The Role of Vitamins in Oral Health. A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2020Pooled it
- A Multilingual Digital Microlearning Intervention for Oral Health in Refugee Shelters: Randomized Controlled Trial.Journal of medical Internet research · 2026Trial
- Efficacy of 3D-Printed Cleaning Splints for Approximal Dental Biofilm Removal-A Randomized Clinical Crossover Pilot Study.Clinical and experimental dental research · 2026Trial
- Effects of a 4-week free-sugar avoidance during periodontal therapy: An explorative randomized controlled clinical trial.Journal of periodontology · 2025Trial
- Intermittent Fasting Regimes Reduce Gingival Inflammation: A Three-Arm Clinical Trial.Journal of clinical periodontology · 2025Trial
- Effect of a Whole-Food Plant-Based Diet on Periodontal Parameters in Patients With Cardiovascular Risk Factors: A Secondary Sub-Analysis of a Randomized Clinical Trial.Journal of clinical periodontology · 2025Trial
- Effects of omega-3 supplementation as an adjunct to non-surgical periodontal therapy on periodontal parameters in periodontitis patients: a randomized clinical trial.BMC oral health · 2022Trial
- How to Measure Adherence to a Mediterranean Diet in Dental Studies: Is a Short Adherence Screener Enough? A Comparative Analysis.Nutrients · 2022Trial
- Effects of a Non-Energy-Restricted Ketogenic Diet on Clinical Oral Parameters. An Exploratory Pilot Trial.Nutrients · 2021Trial
- Trial
- An oral health optimized diet reduces the load of potential cariogenic and periodontal bacterial species in the supragingival oral plaque: A randomized controlled pilot study.MicrobiologyOpen · 2020Trial
- Within-Subject Reliability and between-Subject Variability of Oxidative Stress Markers in Saliva of Healthy Subjects: A Longitudinal Pilot Study.Disease markers · 2017Trial
- Nutrition Habits and Oral Conditions Within a Representative Swiss Cohort of Adult Subjects.Oral health & preventive dentistry · 2026Observational
- Lifestyle Characteristics and Dietary Habits in Romanian Patients with Periodontitis: A Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2026Article
- The effect of vitamin D supplementation on periodontal health: a systematic review and meta-analysis.Evidence-based dentistry · 2026Article
49 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of this pilot study was to investigate the effects of four weeks of an oral health optimized diet on periodontal clinical parameters in a randomized controlled trial.
methodsThe experimental group (n = 10) had to change to a diet low in carbohydrates, rich in Omega-3 fatty acids, and rich in vitamins C and D, antioxidants and fiber for four weeks. Participants of the control group (n = 5) did not change their dietary behavior. Plaque index, gingival bleeding, probing depths, and bleeding upon probing were assessed by a dentist with a pressure-sensitive periodontal probe. Measurements were performed after one and two weeks without a dietary change (baseline), followed by a two week transitional period, and finally performed weekly for four weeks.
resultsDespite constant plaque values in both groups, all inflammatory parameters decreased in the experimental group to approximately half that of the baseline values (GI: 1.10 ± 0.51 to 0.54 ± 0.30; BOP: 53.57 to 24.17 %; PISA: 638 mm(2) to 284 mm(2)). This reduction was significantly different compared to that of the control group.
conclusionA diet low in carbohydrates, rich in Omega-3 fatty acids, rich in vitamins C and D, and rich in fibers can significantly reduce gingival and periodontal inflammation.
trial registrationGerman Clinical Trials Register; https://www.germanctr.de (DRKS00006301). Registered on 2015-02-21.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.