Evidence map›Paper›PMID 27460436›Full record

ArticleEBioMedicine2016

HIV DNA Set Point is Rapidly Established in Acute HIV Infection and Dramatically Reduced by Early ART.

Jintanat Ananworanich, Nicolas Chomont, Leigh Ann Eller, Eugene Kroon, Sodsai Tovanabutra, Meera Bose, Martin Nau, James L K Fletcher, Somporn Tipsuk, Claire Vandergeeten and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EBioMedicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 173 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
173citing papers in PubMed, 3 pooled it
18.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

173 citing papers in PubMed, 3 syntheses or guidelines pooled it, 240 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Trial
  6. Time to Viral Rebound After Interruption of Modern Antiretroviral Therapies.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022
    Trial
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  10. Article
  11. Review
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  15. IBA-1Research square · 2026
    Article
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  18. Article
  19. CD8medRxiv : the preprint server for health sciences · 2025
    Article
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113 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 3 countries.

Jintanat AnanworanichU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA; SEARCH, The Thai Red Cross AIDS Research Centre, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand. Electronic address: jananworanich@hivresearch.org.
Nicolas ChomontCRCHUM and Department of microbiology, infectiology and immunology, Université de Montréal, Montreal, Canada; The Vaccine and Gene Therapy Institute-Florida, Port St. Lucie, Florida, USA.
Leigh Ann EllerU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.
Eugene KroonSEARCH, The Thai Red Cross AIDS Research Centre, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand; Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.
Sodsai TovanabutraU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.
Meera BoseU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.
Martin NauU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.
James L K FletcherSEARCH, The Thai Red Cross AIDS Research Centre, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.
Somporn TipsukSEARCH, The Thai Red Cross AIDS Research Centre, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.
Claire VandergeetenThe Vaccine and Gene Therapy Institute-Florida, Port St. Lucie, Florida, USA.
Robert J O'ConnellCRCHUM and Department of microbiology, infectiology and immunology, Université de Montréal, Montreal, Canada.
Suteeraporn PinyakornU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.
Nelson MichaelU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Nittaya PhanuphakSEARCH, The Thai Red Cross AIDS Research Centre, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.
Merlin L RobbU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.
RV217 and RV254/SEARCH010 study groups
Henry M. Jackson Foundation · USArmed Forces Research Institute of Medical Science · THWalter Reed Army Institute of Research · USVaccine & Gene Therapy Institute of Florida · USUniversité de Montréal · CA

Funding

The Latent HIV Reservoir in Early-treated Thai ChildrenR01AI114236 · NIAID · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · PI PUTHANAKIT, THANYAWEE, ROBB, MERLIN L · 2014 to 2018
$2.8M
Determinants of Resilience in Youth with HIV infection and Youth affected by HIVR01MH102151 · NIMH · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · PI ROBB, MERLIN L · 2014 to 2018
$2.3M
NIAID NIH HHS R01 AI114236NIMH NIH HHS R01 MH102151
6 · The paper itself

Abstract

HIV DNA is a marker of HIV persistence that predicts HIV progression and remission, but its kinetics in early acute HIV infection (AHI) is poorly understood. We longitudinally measured the frequency of peripheral blood mononuclear cells harboring total and integrated HIV DNA in 19 untreated and 71 treated AHI participants, for whom 50 were in the earliest Fiebig I/II (HIV IgM-) stage, that is ≤2weeks from infection. Without antiretroviral therapy (ART), HIV DNA peaked at 2weeks after enrollment, reaching a set-point 2weeks later with little change thereafter. There was a marked divergence of HIV DNA values between the untreated and treated groups that occurred within the first 2weeks of ART and increased with time. ART reduced total HIV DNA levels by 20-fold after 2weeks and 316-fold after 3years. Therefore, very early ART offers the opportunity to significantly reduce the frequency of cells harboring HIV DNA.

Indexed as

DNA, ViralProvirusesAdultAnti-HIV AgentsAntiretroviral Therapy, Highly ActiveCD4 Lymphocyte CountFemaleGenotypeHIV-1HIV InfectionsHumansLeukocytes, MononuclearMaleRNA, ViralViral LoadYoung AdultAnti-HIV AgentsDNA, ViralRNA, ViralAcute HIV infectionArtHIV DNAPersistenceReservoir

Identifiers

PMID27460436
PMCPMC5049918
OpenAlexW2483020535

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.