Evidence map›Paper›PMID 27460426›Full record

Observational studyDiagnostic microbiology and infectious disease2016

Lack of doxycycline antimalarial prophylaxis impact on Staphylococcus aureus tetracycline resistance.

Katrin Mende, Miriam L Beckius, Wendy C Zera, Xin Yu, Ping Li, David R Tribble, Clinton K Murray, Infectious Disease Clinical Research Program Trauma Infectious Disease Outcomes Study Investigative Team

Open access · greenAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Diagnostic microbiology and infectious disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Antimicrobial resistance in methicillin-resistantAntimicrobial agents and chemotherapy · 2019
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Katrin MendeInfectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA; San Antonio Military Medical Center, JBSA Fort Sam Houston, TX, USA; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA. Electronic address: katrin.mende.ctr@mail.mil.
Miriam L BeckiusSan Antonio Military Medical Center, JBSA Fort Sam Houston, TX, USA.
Wendy C ZeraInfectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA; San Antonio Military Medical Center, JBSA Fort Sam Houston, TX, USA; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA.
Xin YuSan Antonio Military Medical Center, JBSA Fort Sam Houston, TX, USA.
Ping LiInfectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA; The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA.
David R TribbleInfectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Clinton K MurraySan Antonio Military Medical Center, JBSA Fort Sam Houston, TX, USA.
Infectious Disease Clinical Research Program Trauma Infectious Disease Outcomes Study Investigative Team
San Antonio Military Medical Center · USHenry M. Jackson Foundation · USUniformed Services University of the Health Sciences · US

Funding

DATA CENTER FOR EPIDEMIOLOGIC INVESTIGATIONS OF HIVN01AI005072 · NIAID · NEW ENGLAND RESEARCH INSTITUTES, INC. · PI MCKINLAY, SONJA M · 1990 to 1994
–
NIAID NIH HHS Y01 AI005072
6 · The paper itself

Abstract

There is concern that susceptibility of Staphylococcus aureus to tetracyclines may decrease due to use of antimalarial prophylaxis (doxycycline). We examined characteristics related to tetracycline resistance, including doxycycline exposure, in S. aureus isolates collected via admission surveillance swabs and inpatient clinical cultures from United States military personnel injured during deployment (June 2009-January 2012). Tetracycline class resistance was determined using antimicrobial susceptibility testing. The first S. aureus isolate from 168 patients were analyzed, of which 38 (23%) isolates were resistant to tetracyclines (class). Tetracycline-resistant isolates had a higher proportion of resistance to clindamycin (P=0.019) compared to susceptible isolates. There was no significant difference in tetracycline resistance between isolates collected from patients with and without antimalarial prophylaxis; however, significantly more isolates had tet(M) resistance genes in the doxycycline exposure group (P=0.031). Despite 55% of the patients receiving doxycycline as antimalarial prophylaxis, there was no association with resistance to tetracyclines.

Indexed as

Tetracycline ResistanceAdultAnti-Bacterial AgentsAntimalarialsChemopreventionCohort StudiesDoxycyclineFemaleGenes, BacterialHumansMalariaMaleMicrobial Sensitivity TestsMilitary PersonnelStaphylococcus aureusUnited StatesAnti-Bacterial AgentsAntimalarialsDoxycyclineAntibiotic resistanceStaphylococcus aureusTetracyclines

Identifiers

PMID27460426
PMCPMC5028282
OpenAlexW2462196071

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.