Evidence map›Paper›PMID 27460266›Full record

Trial reportEuropean journal of clinical nutrition2016

The impact of 1-year vitamin D supplementation on vitamin D status in athletes: a dose-response study.

E M P Backx, M Tieland, K Maase, A K Kies, M Mensink, L J C van Loon, L C P G M de Groot

Open access · greenAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European journal of clinical nutrition, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 4 pooled it
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 4 syntheses or guidelines pooled it, 40 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

E M P BackxDivision of Human Nutrition, Wageningen University, Wageningen, The Netherlands.
M TielandDivision of Human Nutrition, Wageningen University, Wageningen, The Netherlands.
K MaaseNetherlands Olympic Committee*Netherlands Sports Confederation (NOC*NSF), Arnhem, The Netherlands.
A K KiesDSM Biotechnology Center, Delft, The Netherlands.
M MensinkDivision of Human Nutrition, Wageningen University, Wageningen, The Netherlands.
L J C van LoonNUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, The Netherlands.
L C P G M de GrootDivision of Human Nutrition, Wageningen University, Wageningen, The Netherlands.
Wageningen University & Research · NLDSM (Netherlands) · NLMaastricht University · NLNederlands Olympisch Comité Nederlandse Sport Federatie · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectivesTo assess the prevalence of vitamin D deficiency in Dutch athletes and to define the required dosage of vitamin D3 supplementation to prevent vitamin D deficiency over the course of a year. SUBJECTS/

methodsBlood samples were collected from 128 highly trained athletes to assess total 25(OH)D concentration. Of these 128 athletes, 54 male and 48 female athletes (18-32 years) were included in a randomized, double blind, dose-response study. Athletes with either a deficient (<50 nmol/l) or an insufficient (50-75 nmol/l) 25(OH)D concentration were randomly assigned to take 400, 1100 or 2200 IU vitamin D3 per day orally for 1 year. Athletes who had a total 25(OH)D concentration above 75 nmol/l at baseline continued with the study protocol without receiving vitamin D supplements. Serum total 25(OH)D concentration was assessed every 3 months, as well as dietary vitamin D intake and sunlight exposure.

resultsNearly 70% of all athletes showed an insufficient (50-75 nmol/l) or a deficient (<50 nmol/l) 25(OH)D concentration at baseline. After 12 months, serum 25(OH)D concentration had increased more in the 2200 IU/day group (+50±27 nmol/l) than the sufficient group receiving no supplements (+4±17 nmol/l; P<0.01) and the 1100 IU/day group (+25±23 nmol/l; P<0.05). Supplementation with 2200 IU/day vitamin D resulted in a sufficient 25(OH)D concentration in 80% of the athletes after 12 months.

conclusionsVitamin D deficiency is highly prevalent in athletes. Athletes with a deficient or an insufficient 25(OH)D concentration can achieve a sufficient 25(OH)D concentration within 3 months by taking 2200 IU/day.

Indexed as

AthletesDietary SupplementsAdolescentAdultCholecalciferolDouble-Blind MethodFemaleHumansMaleNetherlandsSports MedicineVitamin DVitamin D DeficiencyYoung Adult25-hydroxyvitamin DCholecalciferolVitamin D

Identifiers

PMID27460266
OpenAlexW2496170537

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.