ArticleEuropean journal of clinical nutrition2016
Serum high-sensitivity C-reactive protein as a biomarker in patients with metabolic syndrome: evidence-based study with 7284 subjects.
Article in European journal of clinical nutrition, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 68 citations in OpenAlex.
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- C-reactive protein is not a biomarker of depression severity in drug-naïve obese patients with metabolic syndrome.Acta neuropsychiatrica · 2025Article
- Sex-Specific Associations of Serum Alkaline Phosphatase With Metabolic Syndrome and Its Components: Over 15 Years of Follow-Up Among Iranian Adults.Journal of clinical laboratory analysis · 2025Article
- Loss of significant association between high-sensitivity C-reactive protein (hs-CRP) and metabolic syndrome after adjustment for waist circumference found in 2022 Korea National Health and Nutrition Examination Survey data.Journal of physiological anthropology · 2025Article
- Methylation risk score of C-reactive protein associates sleep health with related health outcomes.Communications biology · 2025Article
- C-reactive protein (CRP) evaluation in human urine using optical sensor supported by machine learning.Scientific reports · 2024Article
- Insulin resistance-related circulating predictive markers in the metabolic syndrome: a systematic review in the Iranian population.Journal of diabetes and metabolic disorders · 2024Review
- Association of maternal exposure to endocrine disruptor chemicals with cardio-metabolic risk factors in children during childhood: a systematic review and meta-analysis of cohort studies.Diabetology & metabolic syndrome · 2024Review
- Association Between High-Sensitivity C-Reactive Protein Trajectories and the Incidence of Metabolic Syndrome:A Retrospective Cohort Study.Journal of inflammation research · 2024Article
- An analysis of the associations of high-sensitivity C-reactive protein and uric acid with metabolic syndrome components in Korean adults by sex: a cross-sectional study using the Korea national health and nutrition examination survey 2016-2018.BMC endocrine disorders · 2023Article
- Systemic inflammation after spinal cord injury: A review of biological evidence, related health risks, and potential therapies.Current opinion in pharmacology · 2022Review
- The Presence of Psoriasis, Metabolic Syndrome and Their Combination Increases the Serum Levels of CRP and CD5L but Not sCD200R1 and sTLR2 in Participants.Journal of personalized medicine · 2022Article
- Metabolic Syndrome and Overactive Bladder Syndrome May Share Common Pathophysiologies.Biomedicines · 2022Review
- The combination of metabolic syndrome and inflammation increased the risk of colorectal cancer.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2022Article
- Article
- Multislice Computed Tomography Angiography Imaging Diagnosis of Lower Extremity Arteriosclerosis in Patients with Hypertension and Its Correlation with the Level of High-Sensitivity C-Reactive Protein.Computational and mathematical methods in medicine · 2022Article
- High-Sensitivity C-Reactive Protein Relationship with Metabolic Disorders and Cardiovascular Diseases Risk Factors.Life (Basel, Switzerland) · 2021Article
- The effect of metabolic syndrome on head and neck cancer incidence risk: a population-based prospective cohort study.Cancer & metabolism · 2021Article
- Moderator role of vitamin D concentrations on the association between metabolic syndrome and C-reactive protein among adults.Archives of endocrinology and metabolism · 2021Article
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Authors and funding
14 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesMetabolic syndrome (MetS) is characterized by abdominal obesity, dyslipidemia, hypertension and glucose intolerance, and is associated with an increased risk of developing cardiovascular disease (CVD), diabetes mellitus and related diseases. Circulating levels of inflammatory markers such as C-reactive-protein (CRP) have reported to be associated with CVD. Against this background, the prevalence of MetS is increasing globally, and thus predictive biomarkers are required for identification of MetS patients at an increased risk. Here we explored the value of CRP as a biomarker in 7284 subjects and also investigated which features of MetS have the greatest association with the hs-CRP level. SUBJECTS/
methodsThe subjects were recruited from the Mashhad stroke and heart atherosclerotic disorder study. Anthropometric factors and biochemical parameters (for example, high-sensitivity CRP (hs-CRP), high-density lipoprotein/low-density lipoprotein, triglycerides (TGs) and fasting blood glucose (FBG)) were determined. Univariate and multivariate analyses were conducted to evaluate the association of hs-CRP and MetS.
resultsOur results illustrated that the concentration of serum hs-CRP increased progressively with the number of MetS components, and subjects who fulfilled the criteria of MetS for waist circumference, TGs, blood pressure and FBG were found to have hs-CRP of 0.53, 0.38, 0.34 and 0.71 mg/l, respectively, higher than matched-subjects. Importantly, FBG had the greatest association with hs-CRP concentration.
conclusionsOur data demonstrate the significant association between MetS components with hs-CRP, indicating that this association was cumulative by increasing the number of the defining features of MetS, supporting further studies to explore the value of emerging marker as a novel method for detecting individuals at high risk of developing MetS.
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