ArticleTransfusion2016
Incidence of transfusion reactions: a multicenter study utilizing systematic active surveillance and expert adjudication.
Article in Transfusion, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 4 syntheses or guidelines pooled it, 145 citations in OpenAlex.
- Transfusion thresholds and other strategies for guiding red blood cell transfusion.The Cochrane database of systematic reviews · 2025Pooled it
- Restrictive versus Liberal blood transfusion strategies for patients undergoing orthopedic surgery: a meta-analysis of randomised trials with trial sequential analysis.Journal of orthopaedic surgery and research · 2025Pooled it
- Intraoperative Cell Salvage for Women at High Risk of Postpartum Hemorrhage During Cesarean Section: a Systematic Review and Meta-analysis.Reproductive sciences (Thousand Oaks, Calif.) · 2022Pooled it
- Avatrombopag and lusutrombopag for thrombocytopenia in people with chronic liver disease needing an elective procedure: a systematic review and cost-effectiveness analysis.Health technology assessment (Winchester, England) · 2020Pooled it
- Efficacy and safety of ferric carboxymaltose infusion in reducing anemia in patients receiving chemotherapy for nonmyeloid malignancies: A randomized, placebo-controlled study (IRON-CLAD).American journal of hematology · 2021Trial
- Frequency of Acute Adverse Transfusion Reactions at King Saud Medical City, Riyadh, Saudi Arabia.Journal of clinical medicine · 2026Article
- Adverse Reactions to Blood Transfusion in Pediatric Cardiac Surgery: A Retrospective Cohort Study at a Single Center.Annals of cardiac anaesthesia · 2026Article
- Epidemiology of Pediatric Transfusion Reactions.JAMA network open · 2026Article
- [Evidence-based and practical: scrutiny of the new guidelines on platelet transfusion].Die Anaesthesiologie · 2025Article
- Perioperative Blood Management.Journal of clinical medicine · 2025Review
- Myoglobin saturation as an intracellular indicator for transfusion need in oncology patients.Transfusion medicine (Oxford, England) · 2025Article
- Challenges in perioperative blood transfusions in kidney transplantation and the need for Patient Blood Management.Blood transfusion = Trasfusione del sangue · 2024Observational
- Transfusion-Associated Circulatory Overload in a Healthy Patient Following a Road Traffic Accident: A Case Report.International medical case reports journal · 2024Article
- Investigation of the patients with recurrent acute transfusion reactions: A single tertiary medical centre experience.The Journal of international medical research · 2023Article
- Article
- Clinical Use of Canine Thawed Refrigerated Plasma: A Historical Case Series.Animals : an open access journal from MDPI · 2023Article
- Can we lower the platelet threshold of ≥ 50 × 10Annals of hematology · 2023Article
- The Incidence and Risk Factors for Allogeneic Blood Transfusions in Pediatric Spine Surgery: National Data.Healthcare (Basel, Switzerland) · 2023Article
- Outcomes of Patients Treated with Blood Transfusion in a Contemporary Tertiary Care Medical Center Intensive Cardiac Care Unit.Journal of clinical medicine · 2023Article
- Incidence and predictors of blood transfusions in one-stage bilateral total hip arthroplasty: a single center prospective cohort study.Archives of orthopaedic and trauma surgery · 2022Article
Corrections and comments
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Authors and funding
15 authors at 7 institutions in 2 countries.
Funding
Abstract
backgroundPrevalence estimates of the serious hazards of transfusion vary widely. We hypothesized that the current reporting infrastructure in the United States fails to capture many transfusion reactions and undertook a multicenter study using active surveillance, data review, and adjudication to test this hypothesis. STUDY DESIGN AND
methodsA retrospective record review was completed for a random sample of 17% of all inpatient transfusion episodes over 6 months at four academic tertiary care hospitals, with an episode defined as all blood products released to a patient in 6 hours. Data were recorded by trained clinical research nurses, and serious reactions were adjudicated by a panel of transfusion medicine experts.
resultsOf 4857 transfusion episodes investigated, 1.1% were associated with a serious reaction. Transfusion-associated circulatory overload was the most frequent serious reaction noted, being identified in 1% of transfusion episodes. Despite clinical notes describing a potential transfusion association in 59% of these cases, only 5.1% were reported to the transfusion service. Suspected transfusion-related acute lung injury/possible transfusion-related acute lung injury, anaphylactic, and hypotensive reactions were noted in 0.08, 0.02, and 0.02% of transfusion episodes, respectively. Minor reactions, including febrile nonhemolytic and allergic, were noted in 0.62 and 0.29% of transfusion episodes, respectively, with 30 and 50% reported to the transfusion service.
conclusionUnderreporting of cardiopulmonary transfusion reactions is striking among academic, tertiary care hospitals. Complete and accurate reporting is essential to identify, define, establish pathogenesis, and mitigate/treat transfusion reactions. A better understanding of the failure to report may improve the accuracy of passive reporting systems.
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Registered trials
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