ArticleRespiratory research2016
Distinct emphysema subtypes defined by quantitative CT analysis are associated with specific pulmonary matrix metalloproteinases.
Article in Respiratory research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01701869 (Microbiology & Immunology of the Chronically-inflamed Airway), which is not on this map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Microbiology & Immunology of the Chronically-inflamed Airway (RESP RES-001 (117027))
Who cites it
24 citing papers in PubMed, 33 citations in OpenAlex.
- Serum proteomics links the cardiorespiratory biomarkers CTRC, OSM, and MMP-10 to exacerbation severity and number in patients with COPD.Clinical science (London, England : 1979) · 2025Article
- Dietary tannic acid attenuates elastase-induced pulmonary inflammation and emphysema in mice.Inflammopharmacology · 2024Article
- Protective Effect of the Total Alkaloid Extract from BulbusInternational journal of chronic obstructive pulmonary disease · 2024Article
- Spatial Transcriptomics Resolve an Emphysema-Specific Lymphoid Follicle B Cell Signature in Chronic Obstructive Pulmonary Disease.American journal of respiratory and critical care medicine · 2024Article
- Multiomics links global surfactant dysregulation with airflow obstruction and emphysema in COPD.ERJ open research · 2023Article
- Pulmonary EV miRNA profiles identify disease and distinct inflammatory endotypes in COPD.Frontiers in medicine · 2022Article
- Recent advances in airway imaging using micro-computed tomography and computed tomography for chronic obstructive pulmonary disease.The Korean journal of internal medicine · 2021Review
- Dysregulation of COVID-19 related gene expression in the COPD lung.Respiratory research · 2021Article
- Distinguishing Smoking-Related Lung Disease Phenotypes Via Imaging and Molecular Features.Chest · 2021Observational
- Influence of Hypoxia on the Epithelial-Pathogen Interactions in the Lung: Implications for Respiratory Disease.Frontiers in immunology · 2021Review
- The Role of Extracellular Vesicles as a Shared Disease Mechanism Contributing to Multimorbidity in Patients With COPD.Frontiers in immunology · 2021Review
- Impact of emphysema on sputum culture conversion in male patients with pulmonary tuberculosis: a retrospective analysis.BMC pulmonary medicine · 2020Article
- Extracellular Vesicles as Mediators of Cellular Cross Talk in the Lung Microenvironment.Frontiers in medicine · 2020Review
- Article
- Imaging-based clusters in former smokers of the COPD cohort associate with clinical characteristics: the SubPopulations and intermediate outcome measures in COPD study (SPIROMICS).Respiratory research · 2019Article
- Effect of the emphysema subtypes of patients with chronic obstructive pulmonary disease on airway inflammation and COTE index.Experimental and therapeutic medicine · 2018Article
- Matrix metalloproteinases in emphysema.Matrix biology : journal of the International Society for Matrix Biology · 2018Review
- Interstitial Features at Chest CT Enhance the Deleterious Effects of Emphysema in the COPDGene Cohort.Radiology · 2018Article
- Proteolytic biomarkers are related to prognosis in COPD- report from a population-based cohort.Respiratory research · 2018Article
- Imaging approaches to understand disease complexity: chronic obstructive pulmonary disease as a clinical model.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Review
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEmphysema is characterised by distinct pathological sub-types, but little is known about the divergent underlying aetiology. Matrix-metalloproteinases (MMPs) are proteolytic enzymes that can degrade the extracellular matrix and have been identified as potentially important in the development of emphysema. However, the relationship between MMPs and emphysema sub-type is unknown. We investigated the role of MMPs and their inhibitors in the development of emphysema sub-types by quantifying levels and determining relationships with these sub-types in mild-moderate COPD patients and ex/current smokers with preserved lung function.
methodsTwenty-four mild-moderate COPD and 8 ex/current smokers with preserved lung function underwent high resolution CT and distinct emphysema sub-types were quantified using novel local histogram-based assessment of lung density. We analysed levels of MMPs and tissue inhibitors of MMPs (TIMPs) in bronchoalveolar lavage (BAL) and assessed their relationship with these emphysema sub-types.
resultsThe most prevalent emphysema subtypes in COPD subjects were mild and moderate centrilobular (CLE) emphysema, while only small amounts of severe centrilobular emphysema, paraseptal emphysema (PSE) and panlobular emphysema (PLE) were present. MMP-3, and -10 associated with all emphysema sub-types other than mild CLE, while MMP-7 and -8 had associations with moderate and severe CLE and PSE. MMP-9 also had associations with moderate CLE and paraseptal emphysema. Mild CLE occurred in substantial quantities irrespective of whether airflow obstruction was present and did not show any associations with MMPs.
conclusionMultiple MMPs are directly associated with emphysema sub-types identified by CT imaging, apart from mild CLE. This suggests that MMPs play a significant role in the tissue destruction seen in the more severe sub-types of emphysema, whereas early emphysematous change may be driven by a different mechanism.
trial registrationTrial registration number NCT01701869 .
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