Evidence map›Paper›PMID 27460097›Full record

ArticleEnvironmental health : a global access science source2016

Associations between microvascular function and short-term exposure to traffic-related air pollution and particulate matter oxidative potential.

Xian Zhang, Norbert Staimer, Tomas Tjoa, Daniel L Gillen, James J Schauer, Martin M Shafer, Sina Hasheminassab, Payam Pakbin, John Longhurst, Constantinos Sioutas and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental health : a global access science source, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 2 pooled it
6.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 78 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Personal exposure to PMJournal of exposure science & environmental epidemiology · 2023
    Article
  12. Article
  13. Article
  14. Association between exposure to air pollutants and the risk of inflammatory bowel diseases visits.Environmental science and pollution research international · 2022
    Article
  15. Impacts of Environmental Insults on Cardiovascular Aging.Current environmental health reports · 2022
    Review
  16. Article
  17. Effects of ambient particulate matter on vascular tissue: a review.Journal of toxicology and environmental health. Part B, Critical reviews · 2020
    Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Xian ZhangDepartment of Epidemiology, School of Medicine, University of California, Irvine, Irvine 224 Irvine Hall, Irvine, CA, 92617-7555, USA.
Norbert StaimerDepartment of Epidemiology, School of Medicine, University of California, Irvine, Irvine 224 Irvine Hall, Irvine, CA, 92617-7555, USA.
Tomas TjoaDepartment of Epidemiology, School of Medicine, University of California, Irvine, Irvine 224 Irvine Hall, Irvine, CA, 92617-7555, USA.
Daniel L GillenDepartment of Statistics, School of Information and Computer Sciences, University of California, Irvine, Irvine, CA, USA.
James J SchauerEnvironmental Chemistry and Technology Program, University of Wisconsin-Madison, Madison, WI, USA.
Martin M ShaferEnvironmental Chemistry and Technology Program, University of Wisconsin-Madison, Madison, WI, USA.
Sina HasheminassabDepartment of Civil and Environmental Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, CA, USA.
Payam PakbinDepartment of Civil and Environmental Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, CA, USA.
John LonghurstSusan Samueli Center for Integrative Medicine, and Cardiology Division, Department of Medicine, School of Medicine, University of California, Irvine, Irvine, CA, USA.
Constantinos SioutasDepartment of Civil and Environmental Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, CA, USA.
Ralph J DelfinoDepartment of Epidemiology, School of Medicine, University of California, Irvine, Irvine 224 Irvine Hall, Irvine, CA, 92617-7555, USA. rdelfino@uci.edu.
University of California, Irvine · USUniversity of Southern California · USUniversity of Wisconsin–Madison · US

Funding

University of California Health Participation in the National COVID Cohort Collaborative (N3C)UL1TR001414 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI COOPER, DAN M, VILAIN, ERIC J. · 2015 to 2023
$35.1M
Institute for Clinical and Translational ScienceUL1TR000153 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI COOPER, DAN M · 2012 to 2015
$12.1M
Ultrafine Particulate Matter &Cardiorespiratory HealthR01ES012243 · NIEHS · UNIVERSITY OF CALIFORNIA-IRVINE · PI DELFINO, RALPH J · 2003 to 2015
$6.0M
NCATS NIH HHS UL1 TR000153NCATS NIH HHS UL1 TR001414NIEHS NIH HHS R01 ES012243
6 · The paper itself

Abstract

backgroundShort-term exposure to ambient air pollution has been associated with acute increases in cardiovascular hospitalization and mortality. However, causative chemical components and underlying pathophysiological mechanisms remain to be clarified. We hypothesized that endothelial dysfunction would be associated with mobile-source (traffic) air pollution and that pollutant components with higher oxidative potential to generate reactive oxygen species (ROS) would have stronger associations.

methodsWe carried out a cohort panel study in 93 elderly non-smoking adults living in the Los Angeles metropolitan area, during July 2012-February 2014. Microvascular function, represented by reactive hyperemia index (RHI), was measured weekly for up to 12 weeks (N = 845). Air pollutant data included daily data from regional air-monitoring stations, five-day average PM chemical components and oxidative potential in three PM size-fractions, and weekly personal nitrogen oxides (NOx). Linear mixed-effect models estimated adjusted changes in microvascular function with exposure.

resultsRHI was inversely associated with traffic-related pollutants such as ambient PM2.5 black carbon (BC), NOx, and carbon monoxide (CO). An interquartile range change increase (1.06 μg/m(3)) in 5-day average BC was associated with decreased RHI, -0.093 (95 % CI: -0.151, -0.035). RHI was inversely associated with other mobile-source components/tracers (polycyclic aromatic hydrocarbons, elemental carbon, and hopanes), and PM oxidative potential as quantified in two independent assays (dithiothreitol and in vitro macrophage ROS) in accumulation and ultrafine PM, and transition metals.

conclusionsOur findings suggest that short-term exposures to traffic-related air pollutants with high oxidative potential are major components contributing to microvascular dysfunction.

Indexed as

Vehicle EmissionsAgedAged, 80 and overAir PollutantsAir PollutionAnimalsArteriolesCaliforniaCarbon MonoxideCohort StudiesEnvironmental ExposureFemaleHumansHyperemiaMacrophagesMaleAir PollutantsCarbon MonoxideNitrogen OxidesOzoneParticulate MatterReactive Oxygen SpeciesVehicle EmissionsAir pollutionMicrovascular functionOxidative potentialParticulate matter components

Identifiers

PMID27460097
PMCPMC4962442
OpenAlexW2483967830

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.