ArticleTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2016
Identification of a five-lncRNA signature for the diagnosis and prognosis of gastric cancer.
Article in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22 citing papers in PubMed, 27 citations in OpenAlex.
- Genetic association analysis of lnc-AMFR-1:1 rs4784659 C > T and neuroblastoma susceptibility in Chinese pediatric patients.Pediatric surgery international · 2026Article
- Prognostic signature of lipid metabolism associated LncRNAs predict prognosis and treatment of lung adenocarcinoma.Frontiers in oncology · 2022Article
- lncRNA DLEU2 promotes gastric cancer progression through ETS2 via targeting miR-30a-5p.Cancer cell international · 2021Article
- A four-lncRNA signature for predicting prognosis of recurrence patients with gastric cancer.Open medicine (Warsaw, Poland) · 2021Article
- Novel Prognostic Model for Gastric Cancer using 13 Co-Expression Long Non-Coding RNAs (LncRNAs).Medical science monitor : international medical journal of experimental and clinical research · 2020Article
- Article
- Identification of a 6-lncRNA prognostic signature based on microarray re-annotation in gastric cancer.Cancer medicine · 2020Article
- A robust qualitative transcriptional signature for the correct pathological diagnosis of gastric cancer.Journal of translational medicine · 2019Article
- A nomogram based on 9-lncRNAs signature for improving prognostic prediction of clear cell renal cell carcinoma.Cancer cell international · 2019Article
- Linc00483 as ceRNA regulates proliferation and apoptosis through activating MAPKs in gastric cancer.Journal of cellular and molecular medicine · 2018Article
- A Potential Prognostic Long Noncoding RNA Signature to Predict Recurrence among ER-positive Breast Cancer Patients Treated with Tamoxifen.Scientific reports · 2018Article
- Prognostic value of long noncoding RNAs in gastric cancer: a meta-analysis.OncoTargets and therapy · 2018Article
- Identification of cancer-related miRNA-lncRNA biomarkers using a basic miRNA-lncRNA network.PloS one · 2018Article
- Development and validation of a prognostic signature for preoperative prediction of overall survival in gastric cancer patients.OncoTargets and therapy · 2018Article
- Expression profiles analysis of long non-coding RNAs identified novel lncRNA biomarkers with predictive value in outcome of cutaneous melanoma.Oncotarget · 2017Article
- Identification of potential long non-coding RNA biomarkers associated with the progression of colon cancer.Oncotarget · 2017Article
- Comprehensive analysis of a novel four-lncRNA signature as a prognostic biomarker for human gastric cancer.Oncotarget · 2017Article
- Identification and validation of a prognostic 9-genes expression signature for gastric cancer.Oncotarget · 2017Article
- The diagnostic/prognostic potential and molecular functions of long non-coding RNAs in the exosomes derived from the bile of human cholangiocarcinoma.Oncotarget · 2017Article
- Transcriptome analysis of miRNA-lncRNA-mRNA interactions in the malignant transformation process of gastric cancer initiation.Cancer gene therapy · 2017Article
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gastric cancer (GC) is one of the most aggressive malignancies and has a poor prognosis. Identifying novel diagnostic and prognostic markers is of great importance for the management and treatment of GC. Long non-coding RNAs (lncRNAs), which are involved in multiple processes during the development and progression of cancer, may act as potential biomarkers of GC. Here, by performing data mining using four microarray data sets of GC downloaded from the Gene Expression Omnibus (GEO) database with different classifiers and risk score analyses, we identified a five-lncRNA signature (AK001094, AK024171, AK093735, BC003519 and NR_003573) displaying both diagnostic and prognostic values for GC. The results of the Kaplan-Meier survival analysis and log-rank test showed that the risk score based on this five-lncRNA signature was closely associated with overall survival time (p = 0.0001). Further analysis revealed that the risk score is an independent predictor of prognosis. Quantitative reverse transcription polymerase chain reaction (qRT-PCR) analysis of 30 pairs of GC tissue samples confirmed that the five lncRNAs were dysregulated in GC, and receiver operating characteristic (ROC) curves showed the high diagnostic ability of combining the five lncRNAs, with an area under the curve (AUC) of 0.95 ± 0.025. The five lncRNAs involved in several cancer-related pathways were identified using gene set enrichment analysis (GSEA). These findings indicate that the five-lncRNA signature may have a good clinical applicability for determining the diagnosis and predicting the prognosis of GC.
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