Evidence map›Paper›PMID 27460050›Full record

Trial reportHerz2017

Influence of influenza vaccination on recurrent hospitalization in patients with heart failure.

H Kaya, O Beton, G Acar, A Temizhan, Y Cavusoğlu, U Guray, M Zoghi, D Ural, A Ekmekci, H Gungor and 6 more

Abstract readClinical Trial
PubMed Publisher
In one paragraph

Trial report in Herz, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
1.3field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Review
  6. Vaccines and cardiovascular outcomes: lessons learned from influenza epidemics.European heart journal supplements : journal of the European Society of Cardiology · 2023
    Article
  7. Article
  8. Observational
  9. Review
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 9 institutions in 1 country.

H KayaFaculty of Medicine, Department of Cardiology, Cumhuriyet University, 58140, Sivas, Turkey. drhakkikaya84@gmail.com.
O BetonFaculty of Medicine, Department of Cardiology, Cumhuriyet University, 58140, Sivas, Turkey.
G AcarFaculty of Medicine, Department of Cardiology, Sutcu Imam University, Kahramanmaras, Turkey.
A TemizhanCardiology Clinics, Yukses Ihtisas Training and Research Hospital, Ankara, Turkey.
Y CavusoğluFaculty of Medicine, Department of Cardiology, Osmangazi University, Eskisehir, Turkey.
U GurayCardiology Clinics, Ankara Numune Training and Research Hospital, Ankara, Turkey.
M ZoghiFaculty of Medicine, Department of Cardiology, Ege University, Izmir, Turkey.
D UralFaculty of Medicine, Department of Cardiology, Koc University, Istanbul, Turkey.
A EkmekciCardiology Clinics, Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital, Istanbul, Turkey.
H GungorFaculty of Medicine, Department of Cardiology, Adnan Menderes University, Aydın, Turkey.
I SariFaculty of Medicine, Department of Cardiology, Marmara University, Istanbul, Turkey.
D OguzFaculty of Medicine, Department of Cardiology, Baskent University, Ankara, Turkey.
H YucelFaculty of Medicine, Department of Cardiology, Cumhuriyet University, 58140, Sivas, Turkey.
A ZorluFaculty of Medicine, Department of Cardiology, Cumhuriyet University, 58140, Sivas, Turkey.
M B YilmazFaculty of Medicine, Department of Cardiology, Cumhuriyet University, 58140, Sivas, Turkey.
TREAT-HF Investigators
Sivas Cumhuriyet Üniversitesi · TRKoç University · TRAnkara Numune Eğitim ve Araştırma Hastanesi · TRBaşkent University · TRDr. Siyami Ersek Göğüs Kalp Ve Damar Cerrahisi Eğitim Ve Araştırma Hastanesi · TREge University · TREskişehir Osmangazi University · TRKahramanmaraş Sütçü İmam University · TRMarmara University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe current study aimed to evaluate the influence of regular annual influenza vaccinations on cardiovascular (CV) death and heart failure-related hospitalizations (HFrH) in stable outpatients with heart failure with reduced ejection fraction.

methodsThe Turkish research team-HF (TREAT-HF) is a network undertaking multicenter, observational cohort studies in HF. This study is a subgroup analysis of TREAT-HF outpatient cohorts who completed a questionnaire on influenza vaccination status and for whom follow-up data were available. A total of 656 patients with available follow-up data for CV death and HFrH including recurrent hospitalization were included in the study. Patients were classified into two groups: those who received regular influenza vaccination (40 %) and those who did not receive vaccination.

resultsDuring a mean follow-up of 15 ±6 months, 113 (18 %) patients had CV death and 471 (72 %) patients had at least one HFrH. The CV death rate was similar in both groups of patients (16 vs. 19 %, p = 0.37), whereas, HFrH and recurrent HFrH were significantly less frequently encountered in patients who received regular influenza vaccination than in those who did not receive vaccination (43 vs. 92 % and 16 vs. 66 %, p < 0.001, respectively). In a multivariate Cox proportional hazards model - in addition to a few clinical factors - vaccination status (HR = 0.30, 95 % CI = 0.17-0.51, p < 0.001) and graduation from university (HR = 0.35, 95 % CI = 0.17-0.72, p = 0.004) remained independently associated with the risk of recurrent HFrH.

conclusionRegular influenza vaccination does not influence CV deaths; however, it decreases HFrH including recurrent episodes of HFrH in outpatients with heart failure with reduced ejection fraction.

Indexed as

ComorbidityDeath, Sudden, CardiacFemaleFollow-Up StudiesHeart FailureHumansInfluenza, HumanInfluenza VaccinesMaleMiddle AgedPatient ReadmissionPrevalenceRisk FactorsTurkeyVaccinationInfluenza VaccinesHeart failureHospitalizationInfluenzaOutpatientsVaccination

Identifiers

PMID27460050
OpenAlexW2504123560

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.