Evidence map›Paper›PMID 27460044›Full record

SynthesisJournal of human nutrition and dietetics : the official journal of the British Dietetic Association2017

Vitamin D supplementation and its influence on muscle strength and mobility in community-dwelling older persons: a systematic review and meta-analysis.

H Rosendahl-Riise, U Spielau, A H Ranhoff, O A Gudbrandsen, J Dierkes

Erratum issuedOpen access · hybridAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of human nutrition and dietetics : the official journal of the British Dietetic Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 66 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed, 9 pooled it
12.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 9 syntheses or guidelines pooled it, 139 citations in OpenAlex.

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  6. Guideline
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  9. Vitamin D supplementation and its influence on muscle strength and mobility in community-dwelling older persons: a systematic review and meta-analysis.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2017
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  12. Effects of Vitamin D on Physical Function: Results From the STURDY Trial.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022
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  16. Vitamin DJournal of cachexia, sarcopenia and muscle · 2021
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6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 3 countries.

H Rosendahl-RiiseDepartment of Clinical Science, University of Bergen, Bergen, Norway.
U SpielauInstitute of Agricultural and Nutritional Sciences, Martin-Luther University Halle-Wittenberg, Halle, Germany.
A H RanhoffDepartment of Clinical Science, University of Bergen, Bergen, Norway.
O A GudbrandsenDepartment of Clinical Medicine, University of Bergen, Bergen, Norway.
J DierkesDepartment of Clinical Medicine, University of Bergen, Bergen, Norway.
University of Bergen · NOMartin Luther University Halle-Wittenberg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIt has been suggested that vitamin D status or supplementation is important for maintaining or improving muscle strength and mobility in older adults. The study results, however, do not provide consistent results. We therefore aimed to summarise the available evidence systematically, including only studies conducted in community-dwelling older persons.

methodsA systematic search of the literature was performed in April of 2016. The systematic review includes studies that used vitamin D with or without calcium supplementation as the exposure variable and various measurements of muscle strength and mobility. The meta-analysis was limited to studies using hand grip strength (HGS) and timed-up-and-go test as the outcome variables.

resultsA total of 15 studies out of 2408 articles from the literature search were included in the systematic review, providing 2866 participants above the age of 65 years. In the majority of studies, no improvement in muscle strength and mobility was observed after administration of vitamin D with or without calcium supplements. In the meta-analysis, we observed a nonsignificant change in HGS [+0.2 kg (95% confidence interval = -0.25 to 0.7 kg; seven studies)] and a small, significant increase in the timed-up-and-go test [0.3 s (95% confidence interval = 0.1 to 0.5 s; five studies)] after vitamin D supplementation. The meta-analyses showed a high degree of heterogeneity between the studies.

conclusionsIn conclusion, we observed no improvement in muscle strength after the administration of vitamin D with or without calcium supplements. We did find a small but significant deterioration of mobility. However, this is based on a limited number of studies and participants.

Indexed as

Dietary SupplementsAgedCalcium, DietaryDatabases, FactualHand StrengthHumansMuscle StrengthObservational Studies as TopicRandomized Controlled Trials as TopicTreatment OutcomeVitamin DCalcium, DietaryVitamin Dageinggaithand strengthmuscle strengthvitamin D

Identifiers

PMID27460044
PMCPMC5248635
OpenAlexW2489417614

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.