ArticleBMC neuroscience2016
The influence of postsynaptic structure on missing quanta at the Drosophila neuromuscular junction.
Article in BMC neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 19 citations in OpenAlex.
- Activity-Dependent Increases in Quantal Size at theJournal of developmental biology · 2025Article
- Distinct input-specific mechanisms enable presynaptic homeostatic plasticity.Science advances · 2025Article
- Postsynaptic BMP signaling regulates myonuclear properties in Drosophila larval muscles.The Journal of cell biology · 2025Article
- Distinct input-specific mechanisms enable presynaptic homeostatic plasticity.bioRxiv : the preprint server for biology · 2024Article
- Postsynaptic BMP signaling regulates myonuclear properties inbioRxiv : the preprint server for biology · 2024Article
- Structural and Functional Synaptic Plasticity Induced by Convergent Synapse Loss in theThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Cul3 and insomniac are required for rapid ubiquitination of postsynaptic targets and retrograde homeostatic signaling.Nature communications · 2019Article
- Synapse-specific and compartmentalized expression of presynaptic homeostatic potentiation.eLife · 2018Article
- Proteomic profiling of neuronal mitochondria reveals modulators of synaptic architecture.Molecular neurodegeneration · 2017Article
- Invaginating Presynaptic Terminals in Neuromuscular Junctions, Photoreceptor Terminals, and Other Synapses of Animals.Neuromolecular medicine · 2017Review
- Input-Specific Plasticity and Homeostasis at the Drosophila Larval Neuromuscular Junction.Neuron · 2017Article
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2 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundSynaptic transmission requires both pre- and post-synaptic elements for neural communication. The postsynaptic structure contributes to the ability of synaptic currents to induce voltage changes in postsynaptic cells. At the Drosophila neuromuscular junction (NMJ), the postsynaptic structure, known as the subsynaptic reticulum (SSR), consists of elaborate membrane folds that link the synaptic contacts to the muscle, but its role in synaptic physiology is poorly understood.
resultsIn this study, we investigate the role of the SSR with simultaneous intra- and extra-cellular recordings that allow us to identify the origin of spontaneously occurring synaptic events. We compare data from Type 1b and 1s synaptic boutons, which have naturally occurring variations of the SSR, as well as from genetic mutants that up or down-regulate SSR complexity. We observed that some synaptic currents do not result in postsynaptic voltage changes, events we called 'missing quanta'. The frequency of missing quanta is positively correlated with SSR complexity in both natural and genetically-induced variants. Rise-time and amplitude data suggest that passive membrane properties contribute to the observed differences in synaptic effectiveness.
conclusionWe conclude that electrotonic decay within the postsynaptic structure contributes to the phenomenon of missing quanta. Further studies directed at understanding the role of the SSR in synaptic transmission and the potential for regulating 'missing quanta' will yield important information about synaptic transmission at the Drosophila NMJ.
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