ReviewSports medicine (Auckland, N.Z.)2017
Impact of Aging on Endurance and Neuromuscular Physical Performance: The Role of Vascular Senescence.
Review in Sports medicine (Auckland, N.Z.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06596304 (Comparing Macro- and Microvascular Responses to Acute Resistance Exercise with and Without Blood Flow Restriction in Young and Older Adults), which is not on this map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparing Macro- and Microvascular Responses to Acute Resistance Exercise with and Without Blood Flow Restriction in Young and Older Adults: a Parallel Group Crossover Randomized Trial
Who cites it
24 citing papers in PubMed, 66 citations in OpenAlex.
- Central and peripheral vascular recovery following resistance exercise with and without blood flow restriction across age groups: a parallel group crossover randomized trial.European journal of applied physiology · 2026Article
- A peripheral perspective on brain health: vascular and skeletal muscle contributions.American journal of physiology. Heart and circulatory physiology · 2026Review
- The gut as a central hub for multi-organ crosstalk in aging.Cellular and molecular life sciences : CMLS · 2026Review
- Associations between within-day step accumulation pattern and clinical measures of physical function: a change-for-change analysis of longitudinal data in community-dwelling older adults.The international journal of behavioral nutrition and physical activity · 2025Article
- Skeletal Muscle as a Mediator of Interorgan Crosstalk During Exercise: Implications for Aging and Obesity.Circulation research · 2025Review
- "Impact of aging on maximal oxygen uptake adjusted for lower limb lean mass, total body mass, and absolute values in runners".GeroScience · 2024Article
- Handgrip Strength Is Associated with Specific Aspects of Vascular Function in Individuals with Metabolic Syndrome.Biomedicines · 2023Article
- Metabolic landscape in cardiac aging: insights into molecular biology and therapeutic implications.Signal transduction and targeted therapy · 2023Review
- Integrated analysis of plasma proteome and cortex single-cell transcriptome reveals the novel biomarkers during cortical aging.Frontiers in aging neuroscience · 2023Article
- Association between age and muscle function, architecture, and composition in long-distance master runners: a cross-sectional study.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2022Article
- Ionizing Radiation-Induced Brain Cell Aging and the Potential Underlying Molecular Mechanisms.Cells · 2021Review
- Icariin improves brain function decline in aging rats by enhancing neuronal autophagy through the AMPK/mTOR/ULK1 pathway.Pharmaceutical biology · 2021Article
- Potential Indirect Mechanisms of Cognitive Enhancement After Long-Term Resistance Training in Older Adults.Physical therapy · 2020Article
- Inactivity and Skeletal Muscle Metabolism: A Vicious Cycle in Old Age.International journal of molecular sciences · 2020Review
- Article
- Neuronal Cells Rearrangement During Aging and Neurodegenerative Disease: Metabolism, Oxidative Stress and Organelles Dynamic.Frontiers in molecular neuroscience · 2019Article
- Is Sitting Time Related with Physical Fitness in Spanishelderly Population? The EXERNET Multicenter Study.The journal of nutrition, health & aging · 2019Article
- Cross-sectional and longitudinal analyses of the association between lung function and exercise capacity in healthy Norwegian men.BMC pulmonary medicine · 2018Observational
- The Effects of Uniquely-Processed Titanium on Balance and Walking Performance in Healthy Older Adults.Journal of functional biomaterials · 2018Article
- Hallmarks of Brain Aging: Adaptive and Pathological Modification by Metabolic States.Cell metabolism · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The portion of society aged ≥60 years is the fastest growing population in the Western hemisphere. Aging is associated with numerous changes to systemic physiology that affect physical function and performance. We present a narrative review of the literature aimed at discussing the age-related changes in various metrics of physical performance (exercise economy, anaerobic threshold, peak oxygen uptake, muscle strength, and power). It also explores aging exercise physiology as it relates to global physical performance. Finally, this review examines the vascular contributions to aging exercise physiology. Numerous studies have shown that older adults exhibit substantial reductions in physical performance. The process of decline in endurance capacity is particularly insidious over the age of 60 years and varies considerably as a function of sex, task specificity, and individual training status. Starting at the age of 50 years, aging also implicates an impressive deterioration of neuromuscular function, affecting muscle strength and power. Muscle atrophy, together with minor deficits in the structure and function of the nervous system and/or impairments in intrinsic muscle quality, plays an important role in the development of neuromotor senescence. Large artery stiffness increases as a function of age, thus triggering subsequent changes in pulsatile hemodynamics and systemic endothelial dysfunction. For this reason, we propose that vascular senescence has a negative impact on cerebral, cardiac, and neuromuscular structure and function, detrimentally affecting physical performance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.