ArticleMalaria journal2016
Performance of rapid diagnostic test, blood-film microscopy and PCR for the diagnosis of malaria infection among febrile children from Korogwe District, Tanzania.
Article in Malaria journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.
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51 citing papers in PubMed, 1 synthesis or guideline pooled it, 76 citations in OpenAlex.
- High value of rapid diagnostic tests to diagnose malaria within children: A systematic review and meta-analysis.Journal of global health · 2020Pooled it
- Spatiotemporal clustering of malaria in southern-central Ethiopia: A community-based cohort study.PloS one · 2019Trial
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- Diagnostic challenges in malaria detection: A comparative diagnostic performance of HRP2-based rapid diagnostic tests, microscopy, and PCR at Bichena primary hospital, Northwest Ethiopia.Parasite epidemiology and control · 2026Article
- Unveiling the overlooked burden of malaria misdiagnosis using lamp-based re-evaluation of routine malaria diagnosis in health centers: implications for public health and clinical practice in Northwest Ethiopia.BMC infectious diseases · 2026Article
- Longitudinal surveillance of Anopheles mosquitoes across different settings in Tanga and Unguja: increased distribution of An. merus in coastal and inland areas of Tanzania.Malaria journal · 2026Article
- Unmasking Malaria: Microscopy and nPCR Reveal the Hidden Misdiagnosis ofInterdisciplinary perspectives on infectious diseases · 2026Article
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- The resurgence of malaria in Northern Iran in 2023: a wake-up call.BMC infectious diseases · 2025Article
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- Evaluating the Diagnostic Accuracy of Rapid Malaria Tests in Pediatric Patients: A Retrospective Cohort Study.Cureus · 2024Article
- Prediction of malaria positivity using patients' demographic and environmental features and clinical symptoms to complement parasitological confirmation before treatment.Tropical diseases, travel medicine and vaccines · 2023Article
- Health workers' adherence to the malaria test, treat and track strategy during the COVID-19 pandemic in malaria high transmission area in Eastern Uganda.Malaria journal · 2023Article
- A Novel Nested Multiplex Polymerase Chain Reaction Assay for Malaria Diagnosis Using the Hydroxymethyl Dihydropterin Pyrophosphokinase-Dihydropteroate Synthase (hppk-dhps) Gene.The American journal of tropical medicine and hygiene · 2023Article
- Accuracy of diagnosis among clinical malaria patients: comparing microscopy, RDT and a highly sensitive quantitative PCR looking at the implications for submicroscopic infections.Malaria journal · 2023Article
- Performance Evaluation of Nested Polymerase Chain Reaction (Nested PCR), Light Microscopy, andPathogens (Basel, Switzerland) · 2022Article
- Ultrasensitive electrochemical genosensors for species-specific diagnosis of malaria.Electrochimica acta · 2022Article
- Prevalence and distribution pattern of malaria and soil-transmitted helminth co-endemicity in sub-Saharan Africa, 2000-2018: A geospatial analysis.PLoS neglected tropical diseases · 2022Article
- Malaria Endemicity in the Rural Communities of Ebonyi State, Nigeria.The Korean journal of parasitology · 2022Article
- Health care provider practices in diagnosis and treatment of malaria in rural communities in Kisumu County, Kenya.Malaria journal · 2022Article
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Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRapid diagnostic tests (RDT) and light microscopy are still recommended for diagnosis to guide the clinical management of malaria despite difficult challenges in rural settings. The performance of these tests may be affected by several factors, including malaria prevalence and intensity of transmission. The study evaluated the diagnostic performance of malaria RDT, light microscopy and polymerase chain reaction (PCR) in detecting malaria infections among febrile children at outpatient clinic in Korogwe District, northeastern Tanzania.
methodsThe study enrolled children aged 2-59 months with fever and/or history of fever in the previous 48 h attending outpatient clinics. Blood samples were collected for identification of Plasmodium falciparum infection using histidine-rich-protein-2 (HRP-2)-based malaria RDT, light microscopy and conventional PCR.
resultsA total of 867 febrile patients were enrolled into the study. Malaria-positive samples were 85/867 (9.8 %, 95 % CI, 7.9-12.0 %) by RDT, 72/867 (8.3 %, 95 % CI, 6.5-10.1 %) by microscopy and 79/677 (11.7 %, 95 % CI, 9.3-14.3 %) by PCR. The performance of malaria RDT compared with microscopy results had sensitivity and positive predictive value (PPV) of 88.9 % (95 % CI, 79.3-95.1 %) and 75.3 % (95 % CI, 64.8-84.0 %), respectively. Confirmation of P. falciparum infection with PCR analysis provided lower sensitivity and PPV of 88.6 % (95 % CI, 79.5-94.7 %) and 84.3 % (95 % CI, 74.7-91.4 %) for RDT compared to microscopy.
conclusionDiagnosis of malaria infection is still a challenge due to variation in results among diagnostic methods. HRP-2 malaria RDT and microscopy were less sensitive than PCR. Diagnostic tools with high sensitivity are required in areas of low malaria transmission.
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