ArticleBMC neurology2016
Predicting dementia in primary care patients with a cardiovascular health metric: a prospective population-based study.
Article in BMC neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 6 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 6 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Domain-specific physical activity levels and risk of dementia: a systematic review and meta-analysis.The Lancet. Public health · 2026Pooled it
- Pooled it
- Cardiovascular Health, 2010 to 2020: A Systematic Review of a Decade of Research on Life's Simple 7.Journal of the American Heart Association · 2025Pooled it
- Multi-domain prognostic models used in middle-aged adults without known cognitive impairment for predicting subsequent dementia.The Cochrane database of systematic reviews · 2023Pooled it
- Physical activity as a protective factor for dementia and Alzheimer's disease: systematic review, meta-analysis and quality assessment of cohort and case-control studies.British journal of sports medicine · 2022Pooled it
- Combining modifiable risk factors and risk of dementia: a systematic review and meta-analysis.BMJ open · 2019Pooled it
- Association of life's simple 7 with cognitive function in a multi-ethnic cohort.The journal of prevention of Alzheimer's disease · 2026Article
- Association of amyloid and cardiovascular risk with cognition: Findings from KBASE.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Longitudinal association between posterior occlusal contact and dementia development in a large retrospective cohort study using a Japanese claims database.Scientific reports · 2024Article
- Plasma proteomic biomarkers and the association between poor cardiovascular health and incident dementia: The UK Biobank study.Brain, behavior, and immunity · 2024Article
- Systemic inflammation, lifestyle behaviours and dementia: A 10-year follow-up investigation.Brain, behavior, & immunity - health · 2024Article
- Predictive Models for the Transition from Mild Neurocognitive Disorder to Major Neurocognitive Disorder: Insights from Clinical, Demographic, and Neuropsychological Data.Biomedicines · 2024Article
- Associations of body habitus and its changes with incident dementia in older adults.Journal of the American Geriatrics Society · 2024Article
- Sex matters in the association between cardiovascular health and incident dementia: evidence from real world data.Alzheimer's research & therapy · 2024Article
- Cardiovascular risk burden, dementia risk and brain structural imaging markers: a study from UK Biobank.General psychiatry · 2024Article
- Association of cardiovascular health with the risk of dementia in older adults.Scientific reports · 2022Article
- Association between Life's Simple 7 and cerebrospinal fluid biomarkers of Alzheimer's disease pathology in cognitively intact adults: the CABLE study.Alzheimer's research & therapy · 2022Article
- Development of a machine learning model to predict mild cognitive impairment using natural language processing in the absence of screening.BMC medical informatics and decision making · 2022Article
- Vascular burden and genetic risk in association with cognitive performance and dementia in a population-based study.Cerebral circulation - cognition and behavior · 2022Article
- Association of Life's Simple 7 with incident dementia and its modification by the apolipoprotein E genotype.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundImproving cardiovascular health possibly decreases the risk of dementia. Primary care practices offer a suitable setting for monitoring and controlling cardiovascular risk factors in the older population. The purpose of the study is to examine the association of a cardiovascular health metric including six behaviors and blood parameters with the risk of dementia in primary care patients.
methodsParticipants (N = 3547) were insurants aged ≥55 of the largest German statutory health insurance company, who were enrolled in a six-year prospective population-based study. Smoking, physical activity, body mass index, blood pressure, total cholesterol, and fasting glucose were assessed by general practitioners at routine examinations. Using recommended cut-offs for each factor, the patients' cardiovascular health was classified as ideal, moderate, or poor. Behaviors and blood parameters sub-scores, as well as a total score, were calculated. Dementia diagnoses were retrieved from health insurance claims data. Results are presented as hazard ratios (HRs) and 95% confidence intervals (95% CIs).
resultsOver the course of the study 296 new cases of dementia occurred. Adjusted for age, sex, and education, current smoking (HR = 1.77, 95% CI 1.09-2.85), moderate (1.38, 1.05-1.81) or poor (1.81, 1.32-2.47) levels of physical activity, and poor fasting glucose levels (1.43, 1.02-2.02) were associated with an increased risk of dementia. Body mass index, blood pressure, and cholesterol were not associated with dementia. Separate summary scores for behaviors and blood values, as well as a total score showed no association with dementia. Sensitivity analyses with differently defined endpoints led to similar results.
conclusionsDue to complex relationships of body-mass index and blood pressure with dementia individual components cancelled each other out and rendered the sum-scores meaningless for the prediction of dementia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.