SynthesisInternational journal of cancer2016
Telomere structure and maintenance gene variants and risk of five cancer types.
Registry-linked trialOpen access · greenAbstract readMeta-Analysis
In one paragraph
Synthesis in International journal of cancer, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02328677 (ColoCare Transdisciplinary Research in Colorectal Cancer Prognosis), which is not on this map. Cited by 42 papers, 8 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 8 pooled it
4.1field-weighted citation impact, top 6% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
ColoCare Transdisciplinary Research in Colorectal Cancer Prognosis
Who cites it
42 citing papers in PubMed, 8 syntheses or guidelines pooled it, 57 citations in OpenAlex.
- Association of rs401681 (C > T) and rs402710 (C > T) polymorphisms in the CLPTM1L region with risk of lung cancer: a systematic review and meta-analysis.Scientific reports · 2024Pooled it
- Pooled it
- Pan-cancer and cross-population genome-wide association studies dissect shared genetic backgrounds underlying carcinogenesis.Nature communications · 2023Pooled it
- Cross-cancer pleiotropic analysis identifies three novel genetic risk loci for colorectal cancer.Human molecular genetics · 2023Pooled it
- Cross-cancer evaluation of polygenic risk scores for 16 cancer types in two large cohorts.Nature communications · 2021Pooled it
- Discovery of common and rare genetic risk variants for colorectal cancer.Nature genetics · 2019Pooled it
- Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways.Nature communications · 2018Pooled it
- Association between TERT rs2853669 polymorphism and cancer risk: A meta-analysis of 9,157 cases and 11,073 controls.PloS one · 2018Pooled it
- Modeling mammalian meiosis with pluripotent stem cells: progress and challenges.Clinical epigenetics · 2026Review
- A novel telomere-associated genes signature for the prediction of prognosis and treatment responsiveness of hepatocellular carcinoma.Biological procedures online · 2025Article
- Telomere Maintenance-Related Genes are Essential for Prognosis in Breast Cancer.Breast cancer (Dove Medical Press) · 2025Article
- DCLRE1B as a novel prognostic biomarker associated with immune infiltration: a pancancer analysis.Scientific reports · 2024Article
- Obesity-Associated Colorectal Cancer.International journal of molecular sciences · 2024Review
- Telomere length as a predictor of therapy response and survival in patients diagnosed with ovarian carcinoma.Heliyon · 2024Article
- rs2736098, a synonymous polymorphism, is associated with carcinogenesis and cell count in multiple tissue types by regulatingHeliyon · 2024Article
- GermlineGenes · 2024Review
- A novel telomere biology disease-associated gastritis identified through a whole exome sequencing-driven approach.The journal of pathology. Clinical research · 2024Article
- Exploring the Relationship betweenGenes · 2023Article
- Review
- DCLRE1B promotes tumor progression and predicts immunotherapy response through METTL3-mediated m6A modification in pancreatic cancer.BMC cancer · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
74 authors at 20 institutions in 7 countries.
Sara KaramiDepartment of Epidemiology, Geisel School of Medicine at Dartmouth, Lebanon, NH.
Younghun HanThe Department of Biomedical Data Science, Geisel School of Medicine at Dartmouth, Lebanon, NH.
Mala PandeDepartment of Gastroenterology, Hepatology and Nutrition, The University of Texas MD Anderson Cancer Center, Houston, TX.
Iona ChengCancer Prevention Institute of California, Fremont, CA; Stanford Cancer Institute, Stanford, CA.
James RuddDepartment of Epidemiology, Geisel School of Medicine at Dartmouth, Lebanon, NH.
Brandon L PierceDepartments of Public Health Sciences and Human Genetics and Comprehensive Cancer Center, The University of Chicago, Chicago, IL.
Ellen L NutterDepartment of Epidemiology, Geisel School of Medicine at Dartmouth, Lebanon, NH.
Fredrick R SchumacherDepartment of Preventive Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA.
Zsofia Kote-JaraiOncogenetics Team, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, London, United Kingdom.
Sara LindstromProgram in Genetic Epidemiology and Statistical Genetics, Harvard T.H. School of Public Health, Boston, MA.
John S WitteDivision of Genetic and Cancer Epidemiology, Department of Epidemiology and Biostatistics and Institute of Human Genetics, University of California, San Francisco, CA.
Shenying FangDepartment of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX.
Jiali HanDepartment of Epidemiology, Fairbanks School of Public Health, Simon Cancer Center, Indiana University, Indianapolis, IN.
Peter KraftDepartment of Epidemiology and Biostatistics, Harvard School of Public Health, Boston, MA.
David J HunterDepartment of Epidemiology and Biostatistics, Harvard School of Public Health, Boston, MA.
Fengju SongDepartment of Epidemiology and Biostatistics, Key Laboratory of Cancer Prevention and Therapy, National Clinical Research Centre of Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, People's Republic of China.
Rayjean J HungLunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada.
James McKayGenetic Cancer Susceptibility Group, Genetic Epidemiology Group International Agency for Research on Cancer (IARC), Lyon, France.
Stephen B GruberDepartment of Preventive Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA.
Stephen J ChanockDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD.
Angela RischDivision of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), Heidelberg, Germany; Translational Lung Research Center Heidelberg (TLRC-H), Member of the German Center for Lung Research (DZL), Heidelberg, Germany.
Hongbing ShenDepartment of Epidemiology and Biostatistics, Collaborative Innovation Center for Cancer Medicine, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, School of Public Health, Nanjing Medical University, Nanjing, People's Republic of China.
Christopher A HaimanDepartment of Preventive Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA.
Lisa BoardmanMayo Clinic, Rochester, MN.
Cornelia M UlrichHuntsman Cancer Institute, Salt Lake City, UT.
Graham CaseyDepartment of Preventive Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA.
Ulrike PetersPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA.
Ali Amin Al OlamaDepartment of Public Health and Primary Care, Center for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, United Kingdom.
Andrew BerchuckDepartment of Obstetrics and Gynecology, Duke University, Durham, NC.
Sonja I BerndtDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD.
Stephane BezieauService de Génétique Médicale, CHU Nantes, Nantes, France.
Paul BrennanGenetic Cancer Susceptibility Group, Genetic Epidemiology Group International Agency for Research on Cancer (IARC), Lyon, France.
Hermann BrennerKlinische Epidemiologie und Alternsforschung, Deutsches Krebsforschungszentrum, Heidelberg, Germany.
Louise BrintonDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD.
Neil CaporasoDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD.
Andrew T ChanDivision of Gastroenterology, Massachusetts General Hospital, Boston, MA.
Jenny Chang-ClaudeDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
David C ChristianiProgram in Genetic Epidemiology and Statistical Genetics, Harvard T.H. School of Public Health, Boston, MA.
Julie M CunninghamMayo Clinic, Rochester, MN.
Douglas EastonDepartment of Public Health and Primary Care, Center for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, United Kingdom.
Rosalind A EelesOncogenetics Team, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, London, United Kingdom.
Timothy EisenAddenbrooke's Hospital, Cambridge Biomedical Campus, Cambridge, United Kingdom.
Manish GalaDivision of Gastroenterology, Massachusetts General Hospital, Boston, MA.
Steven J GallingerLunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada.
Simon A GaytherDepartment of Preventive Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA.
Ellen L GoodeMayo Clinic, Rochester, MN.
Henrik GrönbergDepartment of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.
Brian E HendersonDepartment of Preventive Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA.
Richard HoulstonThe Institute of Cancer Research, London, United Kingdom.
Amit D JoshiDepartment of Epidemiology and Biostatistics, Harvard School of Public Health, Boston, MA.
Sébastien KüryService de Génétique Médicale, CHU Nantes, Nantes, France.
Mari T LandiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD.
Loic Le MarchandDivision of Epidemiology, University of Hawaii Cancer Center, Honolulu, HI.
Kenneth MuirWarwick Medical School, University of Warwick, Coventry, United Kingdom.
Polly A NewcombPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA.
Jenny Permuth-WeyH. Lee Moffitt Cancer Center & Research Institute, Tampa, FL.
Paul PharoahDepartment of Oncology, University of Cambridge, Cambridge, United Kingdom.
Catherine PhelanH. Lee Moffitt Cancer Center & Research Institute, Tampa, FL.
John D PotterPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA.
Susan J RamusDepartment of Preventive Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA.
Harvey RischYale School of Public Health, New Haven, CT.
Joellen SchildkrautUniversity of Virginia, Charlottesville, VA.
Martha L SlatteryHuntsman Cancer Institute, Salt Lake City, UT.
Honglin SongDepartment of Oncology, University of Cambridge, Cambridge, United Kingdom.
Nicolas WentzensenDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD.
Emily WhitePublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA.
Fredrik WiklundDepartment of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.
Brent W ZankeDivision of Hematology, The University of Ottawa, Ottawa Hospital Research Institute, Ottawa, ON.
Thomas A SellersH. Lee Moffitt Cancer Center & Research Institute, Tampa, FL.
Wei ZhengVanderbilt Epidemiology Center and Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN.
Nilanjan ChatterjeeDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD.
Christopher I AmosThe Department of Biomedical Data Science, Geisel School of Medicine at Dartmouth, Lebanon, NH.
Jennifer A DohertyDepartment of Epidemiology, Geisel School of Medicine at Dartmouth, Lebanon, NH. Jennifer.A.Doherty@Dartmouth.edu.
GECCO and the GAME-ON Network: CORECT, DRIVE, ELLIPSE, FOCI, and TRICL
Dartmouth College · USFred Hutch Cancer Center · USHarvard University · USNational Cancer Institute · USUSC Norris Comprehensive Cancer Center · USGerman Cancer Research Center · DEMayo Clinic in Arizona · USMoffitt Cancer Center · USNational Institutes of Health · USUniversity of Cambridge · GBUniversity of Southern California · USCentre international de recherche sur le cancer · FRGénétique Médicale & Génomique Fonctionelle · FRKarolinska Institutet · SEMassachusetts General Hospital · USThe University of Texas MD Anderson Cancer Center · USAddenbrooke's Hospital · GBCancer Genetics (United States) · USCancer Research UK Cambridge Center · GBDuke University Hospital · US
Funding
USC/NORRIS COMPREHENSIVE CANCER CENTER (CORE) SUPPORTP30CA014089 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MYLES G COCKBURN · 1985 to 2026
$181.4MWomen's Cancer ProgramP30CA015083 · NCI · MAYO CLINIC ROCHESTER · PI AKHILESH PANDEY · 1985 to 2026
$151.3MYale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MTranslational Engineering in Cancer (TEC)P30CA023108 · NCI · DARTMOUTH COLLEGE · PI Fred W Kolling IV · 1985 to 2026
$91.3MStatistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ROSNER, BERNARD A · 2000 to 2019
$77.8MValidity of Diet and Activity Measures in WomenP01CA055075 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI RIMM, ERIC B · 1991 to 2009
$41.8MUnderstanding Population Differences in Cancer: The MEC StudyU01CA164973 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI HAIMAN, CHRISTOPHER ALAN, LE MARCHAND, LOIC · 2015 to 2025
$37.4MUse of microfluidic tumor cultures to enable clinical trials of therapies for ovarian cancerP50CA136393 · NCI · MAYO CLINIC ROCHESTER · PI ELLEN L. GOODE · 2009 to 2026
$37.0MTissue and Pathology ResourcesP50CA127003 · NCI · DANA-FARBER CANCER INST · PI BASS, ADAM JOEL · 2007 to 2023
$33.2MJH/CIDR Genotyping for Genome-Wide Association StudiesU01HG004438 · NHGRI · JOHNS HOPKINS UNIVERSITY · PI VALLE, DAVID · 2007 to 2011
$24.2MIndiana Clinical and Translational Sciences InstituteUL1TR001108 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI DENNE, SCOTT C., SHEKHAR, ANANTHA · 2013 to 2017
$23.3MGENETIC SUSCEPTIBILITY TO CANCER IN MULTIETHNIC COHORTSR01CA063464 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HENDERSON, BRIAN E · 2001 to 2005
$23.2MCancer Research UK 10119Cancer Research UK 10124Cancer Research UK 15007Cancer Research UK 16561Cancer Research UK 17528Intramural NIH HHS Z01 CP010200NCATS NIH HHS UL1 TR001108NCATS NIH HHS UL1 TR001863NCI NIH HHS K05 CA154337NCI NIH HHS K07 CA160753NCI NIH HHS P01 CA033619NCI NIH HHS P01 CA055075NCI NIH HHS P01 CA087969NCI NIH HHS P30 CA014089NCI NIH HHS P30 CA015083NCI NIH HHS P30 CA023108NCI NIH HHS P50 CA127003NCI NIH HHS P50 CA136393NCI NIH HHS P50 CA180995NCI NIH HHS R01 CA042182NCI NIH HHS R01 CA048998NCI NIH HHS R01 CA054281NCI NIH HHS R01 CA059045NCI NIH HHS R01 CA060987NCI NIH HHS R01 CA063464NCI NIH HHS R01 CA076366NCI NIH HHS R01 CA081488NCI NIH HHS R01 CA122443NCI NIH HHS R01 CA128978NCI NIH HHS R01 CA137178NCI NIH HHS R01 CA151989NCI NIH HHS R01 CA151993NCI NIH HHS R35 CA197449NCI NIH HHS R37 CA054281NCI NIH HHS U01 CA074783NCI NIH HHS U01 CA137088NCI NIH HHS U01 CA164930NCI NIH HHS U01 CA164973NCI NIH HHS U19 CA148065NCI NIH HHS U19 CA148107NCI NIH HHS U19 CA148112NCI NIH HHS U19 CA148127NCI NIH HHS U19 CA148537NCI NIH HHS UM1 CA167551NCI NIH HHS UM1 CA167552NCI NIH HHS UM1 CA186107NHGRI NIH HHS U01 HG004438NHGRI NIH HHS U01 HG004446NHLBI NIH HHS HHSN268201100001INHLBI NIH HHS HHSN268201100002INHLBI NIH HHS HHSN268201100003INHLBI NIH HHS HHSN268201100004INHLBI NIH HHS HHSN268201100046CNIA NIH HHS HHSN271201100004CNIEHS NIH HHS R01 ES020506NIH HHS S10 OD020069WHI NIH HHS HHSN268201100001CWHI NIH HHS HHSN268201100002CWHI NIH HHS HHSN268201100003CWHI NIH HHS HHSN268201100004CWorld Health Organization 001
Abstract
Telomeres cap chromosome ends, protecting them from degradation, double-strand breaks, and end-to-end fusions. Telomeres are maintained by telomerase, a reverse transcriptase encoded by TERT, and an RNA template encoded by TERC. Loci in the TERT and adjoining CLPTM1L region are associated with risk of multiple cancers. We therefore investigated associations between variants in 22 telomere structure and maintenance gene regions and colorectal, breast, prostate, ovarian, and lung cancer risk. We performed subset-based meta-analyses of 204,993 directly-measured and imputed SNPs among 61,851 cancer cases and 74,457 controls of European descent. Independent associations for SNP minor alleles were identified using sequential conditional analysis (with gene-level p value cutoffs ≤3.08 × 10
Indexed as
Genetic VariationAllelesCase-Control StudiesGenetic Association StudiesGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansLinkage DisequilibriumNeoplasmsOdds RatioPolymorphism, Single NucleotideRiskTelomeraseTelomereTelomere HomeostasisWhite PeopleTelomerasebreast cancercancer riskcolorectal cancerGWASlung cancermeta-analysisovarian cancerprostate cancertelomere maintenancetelomere structure
Identifiers
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Registered trials
NCT02328677ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.