Evidence map›Paper›PMID 27459462›Full record

ReviewAmerican journal of public health2016

Epidemiology of Major Neurodegenerative Diseases in Women: Contribution of the Nurses' Health Study.

Kaitlin A Hagan, Kassandra L Munger, Alberto Ascherio, Francine Grodstein

Open access · greenAbstract readReview
In one paragraph

Review in American journal of public health, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Observational
  8. Review
  9. Article
  10. Dietary Inflammatory Index and clinical course of multiple sclerosis.European journal of clinical nutrition · 2019
    Article
  11. Anti-Obesity Effects of Medicinal and Edible Mushrooms.Molecules (Basel, Switzerland) · 2018
    Review
  12. Review
  13. Stool Immune Profiles Evince Gastrointestinal Inflammation in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Kaitlin A HaganKaitlin A. Hagan, Alberto Ascherio, and Francine Grodstein are with the Channing Division of Network Medicine, Department of Medicine, Brigham & Women's Hospital/Harvard Medical School, and the Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA. Kassandra L. Munger and Alberto Ascherio are with the Department of Nutrition, Harvard T. H. Chan School of Public Health.
Kassandra L MungerKaitlin A. Hagan, Alberto Ascherio, and Francine Grodstein are with the Channing Division of Network Medicine, Department of Medicine, Brigham & Women's Hospital/Harvard Medical School, and the Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA. Kassandra L. Munger and Alberto Ascherio are with the Department of Nutrition, Harvard T. H. Chan School of Public Health.
Alberto AscherioKaitlin A. Hagan, Alberto Ascherio, and Francine Grodstein are with the Channing Division of Network Medicine, Department of Medicine, Brigham & Women's Hospital/Harvard Medical School, and the Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA. Kassandra L. Munger and Alberto Ascherio are with the Department of Nutrition, Harvard T. H. Chan School of Public Health.
Francine GrodsteinKaitlin A. Hagan, Alberto Ascherio, and Francine Grodstein are with the Channing Division of Network Medicine, Department of Medicine, Brigham & Women's Hospital/Harvard Medical School, and the Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA. Kassandra L. Munger and Alberto Ascherio are with the Department of Nutrition, Harvard T. H. Chan School of Public Health.
Harvard University · US

Funding

Long Term Multidisciplinary Study of Cancer in Women: The Nurses Health StudyUM1CA186107 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, STAMPFER, MEIR · 2014 to 2023
$22.3M
Life Course Cancer Epidemiology Cohort in WomenUM1CA176726 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI WILLETT, WALTER C. · 2013 to 2017
$15.7M
Prospective study of biomarkers and risk factors for ALS incidence and progressioR01NS045893 · NINDS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI ASCHERIO, ALBERTO · 2003 to 2016
$4.0M
Urate as a Predictor of Parkinson's Disease Risk and ProgressionR01NS061858 · NINDS · HARVARD SCHOOL OF PUBLIC HEALTH · PI ASCHERIO, ALBERTO · 2009 to 2013
$3.4M
Metabolomics and risk of Parkinson's DiseaseR01NS089619 · NINDS · HARVARD SCHOOL OF PUBLIC HEALTH · PI ASCHERIO, ALBERTO · 2015 to 2019
$3.3M
Molecular Epidemiology of EBV and Multiple SclerosisR01NS047467 · NINDS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI ASCHERIO, ALBERTO · 2005 to 2008
$2.5M
NSAIDs, inflammation and Parkinson's diseaseR01NS048517 · NINDS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI ASCHERIO, ALBERTO · 2005 to 2009
$2.1M
Organochlorine pesticide, PCBs, and ParkinsonsR01ES012667 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI ASCHERIO, ALBERTO · 2005 to 2007
$1.0M
NCI NIH HHS UM1 CA176726NCI NIH HHS UM1 CA186107NIEHS NIH HHS R01 ES012667NINDS NIH HHS R01 NS045893NINDS NIH HHS R01 NS047467NINDS NIH HHS R01 NS048517NINDS NIH HHS R01 NS061858NINDS NIH HHS R01 NS089619
6 · The paper itself

Abstract

objectivesTo review the contribution of the Nurses' Health Study (NHS) to identifying the role of lifestyle, diet, and genetic or biological factors in several neurodegenerative diseases, including cognitive decline, multiple sclerosis, Parkinson's disease, and amyotrophic lateral sclerosis.

methodsWe completed a narrative review of the publications of the NHS and NHS II between 1976 and 2016.

resultsIn primary findings for cognitive function, higher intake of nuts, moderate alcohol consumption, and higher physical activity levels were associated with better cognitive function. Flavonoids, physical activity, and postmenopausal hormone therapy were related to cognitive decline over 2 to 6 years. The NHS also has been integral in establishing Epstein-Barr virus infection, inadequate vitamin D nutrition, cigarette smoking, and obesity as risk factors for multiple sclerosis and inverse associations between cigarette smoking and caffeine and risk of Parkinson's disease. Increased risk of amyotrophic lateral sclerosis has been associated with cigarette smoking and decreased risk associated with obesity.

conclusionsThe NHS has provided invaluable resources on neurodegenerative diseases and contributed to their etiological understanding. We anticipate that the NHS cohorts will continue to make important contributions to the field of neurodegenerative diseases.

Indexed as

NursesAdultEpidemiologic StudiesFemaleHumansLongitudinal StudiesMiddle AgedNeurodegenerative DiseasesProspective StudiesRisk FactorsUnited StatesWomen's Health

Identifiers

PMID27459462
PMCPMC4981803
OpenAlexW2500526526

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.