Evidence map›Paper›PMID 27459460›Full record

ReviewAmerican journal of public health2016

Determinants and Consequences of Obesity.

Adela Hruby, JoAnn E Manson, Lu Qi, Vasanti S Malik, Eric B Rimm, Qi Sun, Walter C Willett, Frank B Hu

Registry-linked trialOpen access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in American journal of public health, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00005152 (Nurses' Health Study), which is not on this map. Cited by 373 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
373citing papers in PubMed, 10 pooled it
48.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00005152 active not recruitingnot on this map

Nurses' Health Study (Cardiovascular Component)

TypeobservationalSponsorBrigham and Women's HospitalRan1980 to 2029Enrolled121,700ConditionsCardiovascular Diseases, Diabetes Mellitus, Coronary Disease, Heart Diseases
3 · Its place in the literature

Who cites it

373 citing papers in PubMed, 10 syntheses or guidelines pooled it, 737 citations in OpenAlex.

  1. Obesity and Left Ventricular Mechanics in Children and Adolescents: A Systematic Review and Meta-Analysis.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2025
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313 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Adela HrubyAdela Hruby is with the Nutritional Epidemiology Program, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA. Vasanti S. Malik, Eric B. Rimm, Qi Sun, Walter C. Willett, and Frank B. Hu are with the Department of Nutrition, Harvard T. H. Chan School of Public Health, Boston. JoAnn E. Manson is with the Division of Preventive Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston. Lu Qi is with the Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA.
JoAnn E MansonAdela Hruby is with the Nutritional Epidemiology Program, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA. Vasanti S. Malik, Eric B. Rimm, Qi Sun, Walter C. Willett, and Frank B. Hu are with the Department of Nutrition, Harvard T. H. Chan School of Public Health, Boston. JoAnn E. Manson is with the Division of Preventive Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston. Lu Qi is with the Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA.
Lu QiAdela Hruby is with the Nutritional Epidemiology Program, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA. Vasanti S. Malik, Eric B. Rimm, Qi Sun, Walter C. Willett, and Frank B. Hu are with the Department of Nutrition, Harvard T. H. Chan School of Public Health, Boston. JoAnn E. Manson is with the Division of Preventive Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston. Lu Qi is with the Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA.
Vasanti S MalikAdela Hruby is with the Nutritional Epidemiology Program, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA. Vasanti S. Malik, Eric B. Rimm, Qi Sun, Walter C. Willett, and Frank B. Hu are with the Department of Nutrition, Harvard T. H. Chan School of Public Health, Boston. JoAnn E. Manson is with the Division of Preventive Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston. Lu Qi is with the Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA.
Eric B RimmAdela Hruby is with the Nutritional Epidemiology Program, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA. Vasanti S. Malik, Eric B. Rimm, Qi Sun, Walter C. Willett, and Frank B. Hu are with the Department of Nutrition, Harvard T. H. Chan School of Public Health, Boston. JoAnn E. Manson is with the Division of Preventive Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston. Lu Qi is with the Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA.
Qi SunAdela Hruby is with the Nutritional Epidemiology Program, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA. Vasanti S. Malik, Eric B. Rimm, Qi Sun, Walter C. Willett, and Frank B. Hu are with the Department of Nutrition, Harvard T. H. Chan School of Public Health, Boston. JoAnn E. Manson is with the Division of Preventive Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston. Lu Qi is with the Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA.
Walter C WillettAdela Hruby is with the Nutritional Epidemiology Program, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA. Vasanti S. Malik, Eric B. Rimm, Qi Sun, Walter C. Willett, and Frank B. Hu are with the Department of Nutrition, Harvard T. H. Chan School of Public Health, Boston. JoAnn E. Manson is with the Division of Preventive Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston. Lu Qi is with the Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA.
Frank B HuAdela Hruby is with the Nutritional Epidemiology Program, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA. Vasanti S. Malik, Eric B. Rimm, Qi Sun, Walter C. Willett, and Frank B. Hu are with the Department of Nutrition, Harvard T. H. Chan School of Public Health, Boston. JoAnn E. Manson is with the Division of Preventive Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston. Lu Qi is with the Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA.
Brigham and Women's Hospital · USTulane University · USHarvard University · US

Funding

Statistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI TWOROGER, SHELLEY S · 2000 to 2019
$77.8M
Validity of Diet and Activity Measures in WomenP01CA055075 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI WILLETT, WALTER C. · 1991 to 2009
$41.8M
Risk Factors for Breast Cancer in Younger NursesR01CA050385 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI ELIASSEN, A. HEATHER, WILLETT, WALTER C. · 1989 to 2019
$32.3M
Transgenic CoreP30DK046200 · NIDDK · TUFTS MEDICAL CENTER · PI GREENBERG, ANDREW S, PERISSI, VALENTINA · 1992 to 2021
$25.0M
Life Course Cancer Epidemiology Cohort in WomenUM1CA176726 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI WILLETT, WALTER C. · 2013 to 2017
$15.7M
RISK FACTORS FOR CVD IN WOMENR01HL034594 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI JoAnn Elisabeth Manson, Lu Qi · 1985 to 2026
$13.8M
Sleep Duration, Childhood Energy Balance, and Insulin Resistance in AdolescenceU54CA155626 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI HU, FRANK B · 2011 to 2015
$9.6M
DIETARY PATTERNS AND RISK OF CARDIOVASCULAR DISEASER01HL060712 · NHLBI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI HU, FRANK B, QI, QIBIN · 1998 to 2021
$8.0M
BIOCHEMICAL AND GENETIC MARKERS OF TYPE 2 DIABETES RISKR01DK058845 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI HU, FRANK B · 2001 to 2013
$7.8M
NCI NIH HHS P01 CA055075NCI NIH HHS P01 CA087969NCI NIH HHS R01 CA050385NCI NIH HHS U54 CA155626NCI NIH HHS UM1 CA176726NHLBI NIH HHS R01 HL034594NHLBI NIH HHS R01 HL060712NIDDK NIH HHS P30 DK046200NIDDK NIH HHS R01 DK058845
6 · The paper itself

Abstract

objectivesTo review the contribution of the Nurses' Health Studies (NHS and NHS II) in addressing hypotheses regarding risk factors for and consequences of obesity.

methodsNarrative review of the publications of the NHS and NHS II between 1976 and 2016.

resultsLong-term NHS research has shown that weight gain and being overweight or obese are important risk factors for type 2 diabetes, cardiovascular diseases, certain types of cancers, and premature death. The cohorts have elucidated the role of dietary and lifestyle factors in obesity, especially sugar-sweetened beverages, poor diet quality, physical inactivity, prolonged screen time, short sleep duration or shift work, and built environment characteristics. Genome-wide association and gene-lifestyle interaction studies have shown that genetic factors predispose individuals to obesity but that such susceptibility can be attenuated by healthy lifestyle choices. This research has contributed to evolving clinical and public health guidelines on the importance of limiting weight gain through healthy dietary and lifestyle behaviors.

conclusionsThe NHS cohorts have contributed to our understanding of the risk factors for and consequences of obesity and made a lasting impact on clinical and public health guidelines on obesity prevention.

Indexed as

NursesAdultCardiovascular DiseasesDiabetes Mellitus, Type 2DietEpidemiologic StudiesFemaleHumansLife StyleLongitudinal StudiesMiddle AgedMortality, PrematureNeoplasmsObesityProspective StudiesRisk Factors

Identifiers

PMID27459460
PMCPMC4981805
OpenAlexW2480974182

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.