Evidence map›Paper›PMID 27459273›Full record

Trial reportClinical cardiology2016

Similar Impact of Clopidogrel or Ticagrelor on Carotid Atherosclerotic Plaque Inflammation.

Minyoung Oh, Cheol Whan Lee, Hyo Sang Lee, Mineok Chang, Jung-Min Ahn, Duk-Woo Park, Soo-Jin Kang, Seung-Whan Lee, Young-Hak Kim, Dae Hyuk Moon and 2 more

Open access · bronzeAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Clinical cardiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Molecular imaging of carotid artery atherosclerosis with PET: a systematic review.European journal of nuclear medicine and molecular imaging · 2020
    Pooled it
  2. Trial
  3. Review
  4. Pleiotropic effects of clopidogrel.Purinergic signalling · 2022
    Review
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Minyoung OhDepartment of Nuclear Medicine, Asan Medical Center, University of Ulsan, Seoul, Korea.
Cheol Whan LeeDepartment of Medicine, Asan Medical Center, University of Ulsan, Seoul, Korea.
Hyo Sang LeeDepartment of Nuclear Medicine, Asan Medical Center, University of Ulsan, Seoul, Korea.
Mineok ChangDepartment of Medicine, Asan Medical Center, University of Ulsan, Seoul, Korea.
Jung-Min AhnDepartment of Medicine, Asan Medical Center, University of Ulsan, Seoul, Korea.
Duk-Woo ParkDepartment of Medicine, Asan Medical Center, University of Ulsan, Seoul, Korea.
Soo-Jin KangDepartment of Medicine, Asan Medical Center, University of Ulsan, Seoul, Korea.
Seung-Whan LeeDepartment of Medicine, Asan Medical Center, University of Ulsan, Seoul, Korea.
Young-Hak KimDepartment of Medicine, Asan Medical Center, University of Ulsan, Seoul, Korea.
Dae Hyuk MoonDepartment of Nuclear Medicine, Asan Medical Center, University of Ulsan, Seoul, Korea.
Seong-Wook ParkDepartment of Medicine, Asan Medical Center, University of Ulsan, Seoul, Korea.
Seung-Jung ParkDepartment of Medicine, Asan Medical Center, University of Ulsan, Seoul, Korea.
Asan Medical Center · KRUniversity of Ulsan · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPlatelets play an important role in inflammation. Inhibitors of the P2Y HYPOTHESIS: We compared the effects of clopidogrel and ticagrelor therapy for carotid atherosclerotic plaque inflammation using

methodsFifty patients with acute coronary syndrome and ≥1

resultsBaseline characteristics were similar between the 2 groups. At 6-month follow-up, low-density lipoprotein cholesterol and C-reactive protein significantly decreased in both groups (P < 0.001). The TBR of the index vessel and aorta significantly decreased in both groups (P < 0.01). The percent change in the MDS TBR of the index vessel was numerically but not significantly lower in the clopidogrel group than in the ticagrelor group (-9.5 ± 14.6% vs -13.5 ± 19.3%; P = 0.427). Likewise, the percent change in the whole-vessel TBR of the index vessel was not different between the 2 groups (P = 0.166). Similar findings were observed for changes in the MDS TBR (P = 0.412) or whole-vessel TBR of the aorta (P = 0.363).

conclusionsCarotid atherosclerotic plaque inflammation significantly decreases to a similar degree following 6 months of either clopidogrel or ticagrelor treatment.

Indexed as

Plaque, AtheroscleroticAdenosineAgedAnti-Inflammatory AgentsCarotid ArteriesCarotid StenosisClopidogrelFemaleFluorodeoxyglucose F18HumansInflammationMaleMiddle AgedPositron Emission Tomography Computed TomographyPredictive Value of TestsProspective StudiesAdenosineAnti-Inflammatory AgentsClopidogrelFluorodeoxyglucose F18Purinergic P2Y Receptor AntagonistsRadiopharmaceuticalsTicagrelorTiclopidineclopidogrelImagingP2Y12 inhibitorsplaque inflammationpositron emission tomographyticagrelor

Identifiers

PMID27459273
PMCPMC6490841
OpenAlexW2492363375

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.